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Zeng Y.,Duke University | Zeng Y.,Peking University | Chen H.,Duke University | Chen H.,Xiangtan University | And 5 more authors.
Journals of Gerontology - Series A Biological Sciences and Medical Sciences | Year: 2013

Background.A comparative analysis between centenarians' children and neighborhood controls is an efficient approach to learn how familial longevity influence and its interaction with environmental factors affect healthy aging. Yet, there are few extant studies that inform this topic; this study expands this literature.Methods.We analyze data from 417 children of centenarians and 560 neighborhood controls without family history of longevity in China (all participants aged 60-80) using ordered logit regression models.Results.We found that, compared to the neighborhood controls and adjusted for various potentially confounding factors, centenarians' children had significantly better instrumental activities of daily living function(p <. 001), smaller number of chronic conditions or health problems(p <. 01), less anxiety and loneliness(p <. 01), better cognitive function (p <. 01), more resilience (p <. 01), better self-rated health (p <. 001), and better self-rated life satisfaction (p <. 001). The results also reveal that interactions between familial longevity influence and one of three environmental factors (whether, as children, they received adequate medical care when ill, number of living children, and household economic conditions) may possibly affect health outcomes at old ages (p <. 05). We discovered that effects of the environmental factors on health outcome are substantially stronger among elders who have no family history of longevity compared to centenarians' children who probably carry positive genes and/or lifestyle behaviors from their long-lived parent(s), which may promote longevity.Conclusion.Familial longevity influence, through genetics and family lifestyle, is significantly associated with various aspects of health at older ages. Interactions between familial longevity influence and some environmental factors may affect health in old age. © The Author 2012. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.

Feng J.,National Institutes of Geriatrics | Feng J.,Capital Medical University | Zhang J.,National Institutes of Geriatrics | Liu M.,National Institutes of Geriatrics | And 9 more authors.
Experimental Gerontology | Year: 2011

Human longevity is a complex heritable genetic trait. Based on substantial evidence from model organisms, it is clear that mitochondria play a pivotal role in aging and lifespan. However, the effects that mitochondrial genome variations have upon longevity and longevity-related phenotypes in Chuang people in China have yet to be established. By genotyping 15 variants for 10 haplogroups in 738 Chuang subjects, including 367 long-lived individuals and 371 controls, we found that haplogroup F was significantly associated with longevity in females of Zhuang population of China (p = 0.003, OR: 2.01, 95%CI: 1.263-3.197). Additionally, haplogroup F was related to higher HDL levels (p < 0.05) in long-lived individuals. Further analysis suggests that the non-synonymous variant m.13928G>C in haplogroup F was also associated with longevity in female Zhuang Chinese which might account for the beneficial effect of F. © 2011 Elsevier Inc.

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