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Nishiyama K.,National Institute of Technology, Tsuruoka College
Chemical Physics Letters | Year: 2013

To control the local fluctuation of the amino acid residues of papain, ARG59, a highly fluctuating residue in papain, has been changed to GLY. We investigated the binding properties of 2-10GLY (peptides with between 2 and 10 glycine residues) to the modified papain structure via molecular dynamics and docking simulations. The change of the ARG59 residue to GLY alters the binding sites for some peptides, and changed its substrate specificity. Furthermore, the modification alters the binding stability of some peptides. Thus, control of the local fluctuations of residues in proteins has the potential to alter the protein's function. © 2012 Elsevier B.V. All rights reserved. Source


Tanaka K.,Nagaoka University of Technology | Kurokawa M.,Nagaoka University of Technology | Moriya K.,National Institute of Technology, Tsuruoka College | Uchiki H.,Nagaoka University of Technology
Journal of Alloys and Compounds | Year: 2013

Solar cells with a three-dimensional (3D) structure were fabricated with a Cu2ZnSnS4 (CZTS) absorber (CZTS 3D-cell). CZTS absorbers were deposited by spray pyrolysis deposition (SPD) onto CdS buffer layers and then annealed in a nitrogen atmosphere without a cover, with a SLG plate cover, and with a CZTS covering layer deposited on a 3D substrate. The short circuit current density (Jsc) was improved by annealing with a CZTS covering layer, due to a reduction of cracks on the surface of the CZTS absorber. A CZTS 3D cell was then fabricated using a solution with lower sulfur concentration to suppress the evaporation of S, which resulted in a reduction of holes on the surface of the CZTS absorber and an increase in Jsc and the conversion efficiency (η). The η value was 1.13%, which is the highest efficiency for a CZTS 3D-solar cell to our knowledge. © 2013 Elsevier B.V. All rights reserved. Source


Nishiyama K.,National Institute of Technology, Tsuruoka College
Applied Physics Letters | Year: 2013

The binding of peptides of 2-10 glycine residues (2-10Gly) to papain on nanofabricated hydrophobic Si surfaces was investigated by molecular dynamics and docking simulations. 5Gly, 7Gly, 9Gly, and 10Gly were distributed on sites near the active center of papain on the Si surface, while 6-10Gly were distributed on sites near the active center of free papain. The Si surface changed the substrate specificity of papain, and modification of this surface should allow full control of substrate specificity. Molecular surgery of proteins in cells may be realized using papain on specially designed surfaces. © 2013 AIP Publishing LLC. Source


Nishiyama K.,National Institute of Technology, Tsuruoka College
Chemical Physics Letters | Year: 2016

The behavior of 15 dipeptides on thermally fluctuating cathepsin K was investigated by molecular dynamics and docking simulations. Four dipeptides were distributed on sites near the active center, and the variations were small. Eleven dipeptides were distributed on sites far from the active center, and the variations were large for nine dipeptides and very large for the other two. The decision tree was constructed using genetic programming, and it accurately classified the 15 dipeptides. The decision tree would accurately estimate the behavior of various peptides, and should significantly contribute to the design of useful peptides. © 2016 Elsevier B.V. All rights reserved. Source


Motohashi H.,National Institute of Technology, Tsuruoka College
Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B | Year: 2010

Influence of sectional shape on power characteristics of open cross flow type micro water turbine was investigated by model experiments. An increase of number of blades caused improvement of turbine efficiency. Ratio of inner diameter to outer diameter of a turbine hardly influences on turbine power characteristics. Efficiency of large turbines was higher than small ones. Following two effects were confirmed by field tests. ( 1 ) Scale effect : Efficiency obtained by field tests using a turbine with a diameter of 1.2m was higher than model tests. (2) Suppress effect of overload: Maximum generated power showed a tendency to be suppressed for a condition supposing over discharge. Source

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