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Mishra S.,National Institute of Technology RourkelaOrissa | Tirkey V.,National Institute of Technology RourkelaOrissa | Ghosh A.,National Institute of Technology RourkelaOrissa | Dash H.R.,National Institute of Technology RourkelaOrissa | And 5 more authors.
Journal of Molecular Structure | Year: 2015

Two new ferrocenyl-cymantrenyl bimetallic chalcones, [(CO)3Mn(η5-C5H4)C(O)CHCH(η5-C5H4)Fe(η5-C5H5)] (1) and [{(CO)3Mn(η5-C5H4)C(O)CHCH(η5-C5H4)}2Fe] (2) have been synthesized. Their reactivity study with triphenylphosphine and bis-(diphenylphosphino)ferrocene led to the isolation of phosphine substituted bimetallic chalcones (3-6). Single crystal X-ray structural characterization for 1 and its phosphine analogue (3) reveals their different conformational identity with anti-conformation for 1, while syn-conformation for 3. Investigation of antimalarial and antibacterial activities was carried out for compounds 1 and 2 against two strains of Plasmodium falciparum (3D7, K1) and four bacterial strains. TD-DFT calculation was performed for compound 1 and electrochemical properties were studied for bimetallic chalcone compounds by cyclic voltammetric technique. © 2015 Elsevier B.V. All rights reserved. Source

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