The National Institute of Technology Calicut ,, , formerly the Calicut Regional Engineering College , is a federally funded technical university and an institute of national importance governed by an act passed by the Parliament of India. The campus is situated at Chathamangalam, 22 kilometres north east of Kozhikode, formerly known as Calicut, on the Kozhikode–Mukkam Road. It was established in 1961 and was known as Calicut Regional Engineering College until 2002. It is one of the National Institutes of Technology established by the Government of India for imparting high standard technical education to students from all over the country. The college is among the very few institutions in the country to host a Supercomputer of its own. Wikipedia.
Appadurai P.,National Institute of Technology Calicut |
Rathinasamy K.,National Institute of Technology Calicut
Toxicology Letters | Year: 2014
Indicine N-oxide, a pyrrolizidine alkaloid present in the plant Heliotropium indicum had shown promising cytotoxic activity in various tumor models. The compound exhibited severe toxicity to hepatocytes and bone marrow cells. The present work was aimed to evaluate the molecular mechanism of the toxicity of indicine N-oxide. We found that indicine N-oxide inhibited the proliferation of various cancer cell lines in a concentration dependent manner with IC50 ranging from 46 to 100μM. At the half maximal inhibitory concentration it blocked the cell cycle progression at mitosis without significantly altering the organization of the spindle and interphase microtubules. The toxicities of the compound at higher concentrations are attributed to its severe depolymerizing effect on both the interphase and spindle microtubules. Binding studies using purified goat brain tubulin indicated that indicine N-oxide binds to tubulin at a distinct site not shared by colchicine or taxol. It decreased the polymer mass of both purified tubulin and MAP-rich tubulin. It was found to induce cleavage of DNA using pUC18 plasmid. The interactions of indicine N-oxide on DNA were also confirmed by computational analysis; which predicted its binding site at the minor groove of DNA. These studies bring to light that the toxicities of indicine N-oxide were due to its DNA damaging effects and depolymerization of microtubules. © 2013 Elsevier Ireland Ltd.
Fayaz S.M.,National Institute of Technology Calicut |
Kumar V.S.S.,National Institute of Technology Calicut |
Rajanikant G.K.,National Institute of Technology Calicut
CNS and Neurological Disorders - Drug Targets | Year: 2014
Conventional knowledge considered apoptosis as the sole form of programmed cell death during development, homeostasis and diseases, whereas necrosis was regarded as an unregulated and uncontrollable process. Recent revelations suggest that necrosis can also occur in a regulated, caspase-independent manner and shares characteristics with both necrosis and apoptosis. The major cell death processes namely apoptosis, autophagy and necrosis are interlinked and contain many common regulatory mechanisms. Mounting evidence indicates that necroptosis contributes to the pathogenesis of various diseases, including ischemic stroke, traumatic brain injury, neurodegenerative disorders and brain tumor. We present here an overview of the molecular mechanisms governing necroptosis and its connection with apoptosis and autophagy processes. Further, the necroptosis mechanisms underlying the neurodegeneration during ischemia reperfusion (I/R) injury are described, with an emphasis on the key proteins involved in this type of cell death. Knowledge regarding programmed cell death (PCD) with relevance to necroptosis may play a significant role in debilitating brain disorders. © 2014 Bentham Science Publishers.
Jagadeesha T.,National Institute of Technology Calicut
International Journal of Advanced Manufacturing Technology | Year: 2017
Resistance spot welding is one of the oldest and effective joining processes which generates heat by sending an electrical current through the sheets at controlled time and pressure to develop a joint at the interface of the sheets. As the demand for spot welding is drastically increased due to the increase in manufacturing of biomedical and automotive components, a detailed study on the quality of weld generated during the resistance spot welding is required. The quality of spot weld is assessed from the tensile shear strength and weld nugget diameter. An attempt is made through this research work, to study the quality of weld developed by the spot welding process of 1.6-mm-thick 316L-type austenitic stainless steel sheets (1.6 + 1.6 mm). The effect of significant process parameters namely heating time and welding current on ultimate tensile shear strength, weld nugget diameter, and failure modes is studied extensively. The critical weld nugget diameter is predicted by utilizing the proposed analytical model to ensure the tearing-type failure under a tensile shear test. Metallographic and SEM fractograph examinations are carried out to characterize the resistance spot welds. Based on the results, it is inferred that the weld nugget size, i.e., diameter and fusion depth, is the controlling factor of ultimate tensile shear strength and the resulting spot weld failure modes. © 2017 Springer-Verlag London
Mohanraj M.,Information Institute of Engineering |
Jayaraj S.,National Institute of Technology Calicut |
Muraleedharan C.,National Institute of Technology Calicut
Renewable and Sustainable Energy Reviews | Year: 2012
In this paper, an attempt has been made to review the applications of artificial neural networks (ANN) for energy and exergy analysis of refrigeration, air conditioning and heat pump (RACHP) systems. The studies reported are categorized into eight groups as follows: (i) vapour compression systems (ii) RACHP systems components, (iii) vapour absorption systems, (iv) prediction of refrigerant properties (v) control of RACHP systems, (vi) phase change characteristics of refrigerants, (vii) heat ventilation air conditioning (HVAC) systems and (viii) other special purpose heating and cooling applications. More than 90 published articles in this area are reviewed. Additionally, the limitations with ANN models are highlighted. This paper concludes that ANN can be successfully applied in the field of RACHP systems with acceptable accuracy. © 2011 Elsevier Ltd. All rights reserved.
Satyanarayana M.,National Institute of Technology Calicut |
Muraleedharan C.,National Institute of Technology Calicut
Energy | Year: 2011
In the present study, rubber seed oil, coconut oil and palm kernel oil, which are locally available especially in Kerala (India), are chosen and their transesterification processes have been investigated. The various process variables like temperature, catalyst concentration, amount of methanol and reaction time were optimized. Biodiesel from rubber seed oil (with high free fatty acid) was produced by employing two-step pretreatment process (acid esterification) to reduce acid value from 48 to 1.72mg KOH/g with 0.40 and 0.35 v/v methanol-oil ratio and 1.0% v/v H2SO4 as catalyst at a temperature of 63(±2)°C with 1h reaction time followed by transesterification using methanol-oil ratio of 0.30 v/v, 0.5 w/v KOH as alkaline catalyst at 55(±2)°C with 40min reaction time to yield 98-99% biodiesel. Coconut oil and palm oil, being edible oils, transesterification with 0.25 v/v methanol-oil ratio, 0.50% w/v KOH as at 58(±2)°C, 20min reaction time for coconut oil and 0.25% v/v methanol-oil ratio, 0.50% w/v KOH as alkaline catalyst at 60(±2)°C for palm kernel oil will convert them to 98-99% biodiesel. The brake thermal efficiency of palm oil biodiesel was higher with lower brake specific fuel consumption, but rubber seed oil biodiesel(ROB) showed less emission (CO and NOx) compared to other biodiesels. © 2010 Elsevier Ltd.
Nidheesh P.V.,National Institute of Technology Calicut
RSC Advances | Year: 2015
Fenton processes have gained much attention in the field of wastewater treatment during recent years. In order to overcome the disadvantages of Fenton processes, research has focused more on the heterogeneous Fenton process, with highly active and stable solid catalysts. This review reports on advances in the field of heterogeneous Fenton processes in recent years, especially focusing on the various heterogeneous catalysts used. After a general introduction to the various Fenton processes, their advantages and the importance of heterogeneous Fenton processes, various catalysts used in heterogeneous Fenton processes are described in detail. These catalysts are divided into iron minerals, zero-valent iron, waste materials, iron- and iron oxide-loaded materials, and clay. The properties, stability, activity and pollutant degradation mechanism of various catalysts are also discussed in detail. © The Royal Society of Chemistry 2015.
Subha D.P.,National Institute of Technology Calicut
Journal of medical systems | Year: 2010
The EEG (Electroencephalogram) signal indicates the electrical activity of the brain. They are highly random in nature and may contain useful information about the brain state. However, it is very difficult to get useful information from these signals directly in the time domain just by observing them. They are basically non-linear and nonstationary in nature. Hence, important features can be extracted for the diagnosis of different diseases using advanced signal processing techniques. In this paper the effect of different events on the EEG signal, and different signal processing methods used to extract the hidden information from the signal are discussed in detail. Linear, Frequency domain, time - frequency and non-linear techniques like correlation dimension (CD), largest Lyapunov exponent (LLE), Hurst exponent (H), different entropies, fractal dimension(FD), Higher Order Spectra (HOS), phase space plots and recurrence plots are discussed in detail using a typical normal EEG signal.
Das S.,National Institute of Technology Calicut |
Rajanikant G.K.,National Institute of Technology Calicut
Neuroscience and Biobehavioral Reviews | Year: 2014
Over the past decade, zebrafish has proved to be very useful in modeling neurodegenerative conditions. It poses a number of advantages and has been accepted as one of the best models for elucidating pathophysiological mechanisms of neurodegenerative diseases, including Huntington disease (HD). HD is a debilitating neurodegenerative genetic disorder that affects a person's ability to think, talk, and move. The pathophysiology of HD is not completely understood, which prevents the development of effective therapeutic approaches. Using zebrafish as a model organism, scientific advancements can be made in understanding the HD pathology/mechanisms with the hope of developing potential therapies in the near future. © 2014 Elsevier Ltd.
Vinod V.,P.A. College |
Sridharan R.,National Institute of Technology Calicut
International Journal of Production Economics | Year: 2011
This paper presents the salient aspects of a simulation study conducted to investigate the interaction between due-date assignment methods and scheduling rules in a typical dynamic job shop production system. The due-date assignment methods investigated are dynamic processing plus waiting time, total work content, dynamic total work content and random work content method. Seven scheduling rules are incorporated in the simulation model for the scheduling of jobs on machines. The performance of the system is evaluated using various measures based on flow time and tardiness of jobs. Simulation experiments are carried out for the different scenarios that arise out of the combination of due-date assignment methods and scheduling rules. The simulation results are subjected to statistical analysis. It is found that dynamic due-date assignment methods provide better performance. Regression-based metamodels are developed using the simulation results. These metamodels have been found to be valid analytical models of the simulation model. © 2010 Elsevier B.V. All rights reserved.
Manoj V.J.,Kerala University |
Elias E.,National Institute of Technology Calicut
Information Sciences | Year: 2012
Nonuniform filter bank transmultiplexer (NUFB TMUX) can be used to implement multicarrier communication system where applications with different data rates are to be multiplexed. It is possible to reduce the hardware complexity of the NUFB TMUX by representing the filter coefficients in canonic signed digit (CSD) format. In this paper the design of a multiplier-less NUFB TMUX is presented. NUFB TMUX with continuous filter coefficients is designed and the filter coefficients are synthesized in CSD format. Filter coefficient synthesis in CSD format is formulated as an optimization problem and an artificial bee colony (ABC) algorithm is used for the optimization. To preserve the canonic nature of filter coefficients in the ABC algorithm the filter coefficients are encoded using a look-up table. The look-up table also provides the number of signed power-of-two (SPT) terms in the CSD numbers. Simulation results show that the performance of the multiplier-less NUFB TMUX designed using the proposed ABC algorithm is much better than that of the multiplier-less NUFB TMUX obtained by rounding the continuous coefficients of filters to the nearest CSD number. Multiplier-less NUFB TMUX designed by the proposed ABC algorithm also outperforms that designed using genetic algorithm (GA) and particle swarm optimization (PSO). © 2010 Elsevier Inc. All rights reserved.