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Narayanan N.,JKK Nataraja Dental College and Hospital | Suba V.,National Institute of Siddha
Lipids in Health and Disease | Year: 2011

Background: A system that can deliver multi-drug at a prolonged rate is very important for the treatment of various chronic diseases such as diabetes, asthma and heart disease. Controlled porosity osmotic pump tablet (CPOP) system was designed to deliver Nifedipine (NP) and Metoprolol (MP) in a controlled manner up to 12 h. It was prepared by incorporating drugs in the core and coated with various types (PVP, PEG-400 and HPMC) and levels (30, 40 and 50% w/w of polymer) of pore former at a weight gain of 8, 12 & 15%. Results: Formulation variables like type and level of pore former and percent weight gain of membrane was found to affect the drug release from the developed formulations. Drug release was inversely proportional to the membrane weight but directly related to the level of pore former. Burst strength of the exhausted shell was inversely proportional to the level of pore former, but directly affected by the membrane weight. Results of scanning electron microscopy (SEM) studies showed the formation of pores in the membrane from where the drug release occurred. Dissolution models were applied to drug release data in order to establish the mechanism of drug release kinetics. In vitro release kinetics was subjected to superposition method to predict in vivo performance of the developed formulation. Conclusion: The developed osmotic system is effective in the multi-drug therapy of hypertension by delivering both drugs in a controlled manner. © 2011 Kumaravelrajan et al; licensee BioMed Central Ltd.

Thanigavelan V.,Sairam Advanced Center for Research | Thanigavelan V.,Sri Sairam Siddha Medical College and Research Center | Kaliyamurthi V.,Sairam Advanced Center for Research | Lakshmanakumar V.,Sri Sairam Siddha Medical College and Research Center | And 2 more authors.
Journal of Applied Pharmaceutical Science | Year: 2013

Karpoora Cinthamani Mathirai (KCM) is a traditional Siddha medicinal preparation using to treat Arthritis associated with fever narrated in the text Anubhoga Vaithiya Navaneetham. This formulation has the detoxified ingredients such as Hydrargyrum subchloride and Croton tiglium seeds. The aim was to establish a fingerprint to ensure the quality and safety of KCM. Physicochemical characterization of KCM was carried out using qualitative biochemical analysis and modern techniques such as Fourier transform infra-red spectroscopy, inductively coupled plasma analysis and scanning electron microscopy. Physical evaluation revealed that KCM is a light green colour pill, neutral nature and having solubility in water and HCl with stabilized particle size distribution of 3μ. A clearly identifiable fraction of KCM particles were below 50 nm. The presence of nano sized particles and functional groups carboxylic acids and nitrocompounds in KCM might impart the therapeutic property. Trace elemental analysis of KCM revealed that heavy metals like arsenic, cadmium, mercury and lead were below the deduction limit. Further, elemental analysis of KCM revealed the presence of minerals like calcium, iron, potassium, sodium, and phosphorus under acceptable limits at the prescribed dose of KCM.

R M.,National Institute of Siddha | Ramaswamy R.S.,Central Council for Research in Siddha
International Journal of Pharma and Bio Sciences | Year: 2015

Siddha system of medicine is a traditional system practised among Tamil speaking people of India. Siddhars, the ancient scientists are the founders of this system. Herbs, minerals/metals and animal products are used in medicine preparation. Kandhga Rasayanam is a herbo mineral drug mentioned in classic Siddha text. It is used in treating skin diseases, urinary infections, venereal diseases, arthritis etc. The present review is aimed to collect information about toxicity studies and phytoconstituents substantiating the traditional claim of safety and efficacy. Most of the herbal drugs were found to be nontoxic and rich in secondary metabolites responsible for antimicrobial, antifungal and antioxidant properties. This compound drug mentioned in Siddha literature is thus validated.

Meena R.,National Institute of Siddha | Ramaswamy R.S.,CCRS
International Journal of Pharma and Bio Sciences | Year: 2013

Existence of Siddha system of medicine can be traced to ancient times. It has survived the onslaught of various other systems of medicines proving its efficacy. Siddhars were experts in medicine preparations which cured innumerable diseases. Pharmacovigilance is defined as the science of detection, assessment, understanding and prevention of adverse drug effects or any other possible drug related problems. Although the term pharmacovigilance is actually not featured in Siddha texts, it is vibrant throughout literature. This paper deals with the historical perspectives, adverse drug reactions in Siddha system, need for pharmacovigilance, challenges faced, pharmacovigilance of clinical trials, measures to improve pharmacovigilance of herbal medicines and future suggestions.

Kabilan N.,Tamil Nadu Dr. M.G.R.Medical University | Murugesan M.,National Institute of Siddha
Der Pharmacia Lettre | Year: 2016

The main aim of the present research work is to evaluate the safety of the traditional siddha medicine Natural PooraParpam (NPP) and Synthetic PooraParpam (SPP) by determining its possible toxicity after acute and subacute administration in rodents. In short term acute toxicity study the drug NPP and SPP was administered in single doss of 1.28 mg / kg b.w (p.o). Potential drug toxicity related to C.N.S, A.N.S and C.V.S were observed up to 14 days. In sub-acute toxicity study the drug NPP and SPP was administered at three dose level such as low dose, middle dose and high dose of 1.15, 1.44 and 2.88 mg / kg b.w (p.o) for four weeks, 5ml of KarumbuVellam (Cane sugar)] mixed with water served as vehicle control group and saline treated group served as normal control. Results obtained from the acute and sub-acute study reveals that the drug NPP and SPP doesn't cause any significant change in behavior, mortality and other potential adverse effects on treated animals. Throughout the study period no sign of toxicity was registered. Further it was observed that NPP and SPP at all three dose level did not modify the weight index, food and water intake in treated animals. There is no significant change in hematological, biochemical and histopathological observation of animals treated with NPP and SPP at the dose of 1.15, 1.44 and 2.88 mg / kg b.w (p.o) when compare to control group animals. From the result it was concluded that both the formulation NPP and SPP offers wide margin of safety in tested rodents and further long tern usage of drugs will be considered as safe for the ailment of various disease.

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