National Institute of Science Education and Research NISER Bhubaneswar

Khurda, India

National Institute of Science Education and Research NISER Bhubaneswar

Khurda, India
SEARCH FILTERS
Time filter
Source Type

Maiti S.,National Institute of Science Education and Research NISER Bhubaneswar | Mal P.,National Institute of Science Education and Research NISER Bhubaneswar
Organic Letters | Year: 2017

An intermolecular dehydrogenative annulation (IDA) for carbazole synthesis via sequential C-C/C-N bond formation with a selective alkyl group migration is reported. Using the hypervalent iodine(III) reagent PhI(OAc)2 (PIDA), in a one-pot operation, up to five C(sp2)-H bonds, one N(sp3)-H bond functionalization, and one alkyl (Me, Et) group migration could all be achieved from non-prefunctionalized 1,3,5-trialkylbenzenes and anilides under ambient laboratory conditions. Mechanistically, it is shown that PIDA reacts with anilides to generate a nitrenium ion or an equivalent carbenium ion which influences the second aromatic ring to be activated for C-C/C-N bond formation. Strategically, regioselective fusion of arenes to anilides is described. © 2017 American Chemical Society.


PubMed | SCB Medical College, Meharry Medical Center, National Institute of Science Education and Research NISER Bhubaneswar, Howard University and 3 more.
Type: | Journal: The international journal of biochemistry & cell biology | Year: 2016

Hypoxia enhances immortality and metastatic properties of solid tumors. Deregulation of histone acetylation has been associated with several metastatic cancers but its effect on hypoxic responses of cancer cells is not known. This study aimed at understanding the effectiveness of the hydrazinocurcumin, CTK7A, an inhibitor of p300 lysine/histone acetyltransferase (KAT/HAT) activity, in inducing apoptosis of gastric cancer cells (GCCs) exposed to cobalt chloride (CoCl


Giri C.,National Institute of Science Education and Research NISER Bhubaneswar | Giri C.,University of Jyväskylä | Sahoo P.K.,National Institute of Science Education and Research NISER Bhubaneswar | Puttreddy R.,University of Jyväskylä | And 2 more authors.
Chemistry - A European Journal | Year: 2015

Subcomponent self-assembly from components A, B, C, D, and Fe2+ under solvent-free conditions by self-sorting leads to the construction of three structurally different metallosupramolecular iron(II) complexes. Under carefully selected ball-milling conditions, tetranuclear [Fe4(AD2)6]4- 22-component cage 1, dinuclear [Fe2(BD2)3]2- 11-component helicate 2, and 5-component mononuclear [Fe(CD3)]2+ complex 3 were prepared simultaneously in a one-pot reaction from 38 components. Through subcomponent substitution reaction by adding subcomponent B, the [Fe4(AD2)6]4- cage converts quantitatively to the [Fe2(BD2)3]2- helicate, which, in turn, upon addition of subcomponent C, transforms to [Fe(CD3)]2+, following the hierarchical preference based on the thermodynamic stability of the complexes. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Maiti S.,National Institute of Science Education and Research NISER Bhubaneswar | Mal P.,National Institute of Science Education and Research NISER Bhubaneswar
Advanced Synthesis and Catalysis | Year: 2015

A transition metal-free, hypervalent iodine(III) reagent [phenyliodine diacetate (PIDA)]-mediated C(sp2)-H amidation in trifluoroethanol (TFE) has been developed. The intramolecular coupling methodology presented here provides a direct access to 1,2-disubstituted multifunctional benzimidazoles in good to excellent yields. The reactions were performed in the open air and at ambient temperature, and were found to be eco-friendly and atom-economical. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Mishra V.K.,University of Tübingen | Ravikumar P.C.,National Institute of Science Education and Research NISER Bhubaneswar | Maier M.E.,University of Tübingen
Tetrahedron | Year: 2016

With a view towards the synthesis of lycorane-like structures several N-(pivaloyloxy)benzamides were reacted with cyclohexa-1,3-diene in presence of a rhodium(III) catalyst which resulted via C–H activation in the corresponding tetrahydrophenanthridinones 12a–d and 19. Subsequently, various strategies were explored to convert these tricyclic phenanthridinones to the tetracyclic core structure of the lycoranes. While radical based approaches were not successful, we were able to form ring D (pyrrolidine ring) by a nickel catalyzed reaction, resulting in alkaloid derivatives 39 and 40. © 2016 Elsevier Ltd


Achar T.K.,National Institute of Science Education and Research NISER Bhubaneswar | Maiti S.,National Institute of Science Education and Research NISER Bhubaneswar | Mal P.,National Institute of Science Education and Research NISER Bhubaneswar
Organic and Biomolecular Chemistry | Year: 2016

Iodinium cation (I+ or IOAc) was produced from the combination of phenyliodine diacetate (PIDA) and iodine. I+ facilitated the direct vicinal difunctionalization of olefins to α-azido, α-trideuteriomethoxy, α-2,2,2-trifluoroethoxy and α-acyloxy alkyl iodides via cation-π interaction at room temperature and under transition-metal free conditions. © The Royal Society of Chemistry 2016.


PubMed | National Institute of Science Education and Research NISER Bhubaneswar
Type: Journal Article | Journal: Organic & biomolecular chemistry | Year: 2016

Iodinium cation (I(+) or IOAc) was produced from the combination of phenyliodine diacetate (PIDA) and iodine. I(+) facilitated the direct vicinal difunctionalization of olefins to -azido, -trideuteriomethoxy, -2,2,2-trifluoroethoxy and -acyloxy alkyl iodides via cation- interaction at room temperature and under transition-metal free conditions.


PubMed | DRB Sindhu Mahavidyalaya and National Institute of Science Education and Research NISER Bhubaneswar
Type: | Journal: Journal of neuroendocrinology | Year: 2016

Dopamine (DA) has emerged as the potent inhibitory neuromodulator of LH secretion and reproduction in teleosts. The DA neurons located in the anterior subdivision of nucleus preopticus periventricularis (NPPa) in the preoptic area (POA) innervate the pituitary gland and regulate the LH cells. Although reduction in the inhibitory DAergic tone is crucial for stimulatory action of GnRH on LH cells, the role of other hypothalamic factors is suggested but not fully understood. Nonapeptide, isotocin (IST) has emerged as a likely candidate that may also influence the LH cell function. IST neurons reside in the nucleus preopticus and innervate LH cells. While ISTtreatment dramatically elevated LH secretion, the IST levels in brainpeaked during spawning. In a pilot study on the catfish,Clarias batrachus, we observed a dense network of IST-immunoreactive (IST-ir) fibers in NPPa, the region known to harbor hypophysiotropic DA neurons. Application of double immunofluorescence method showed dense IST-ir fiber network around thetyrosine hydroxylase (TH)-ir neurons in NPPa region. A great majority of the TH-ir neurons in NPPa were contacted by IST-ir fibers during spawning phase. The NPPatherefore seems to be asite for intense interaction of DA and IST. The IST-ir fiber innervation in NPPa showed reproduction phase-dependent changes. The percent fluorescent area of IST-ir fibers showed gradual increase from the resting through prespawning phases (Resting: 7.5 1.04; Preparatory: 8.6 0.8; Prespawning: 15.5 1.4) reaching a peak in spawning phase (28 2.3; P<0.001). Compared to spawning phase, a drastic reduction in IST-ir fibers in the NPPa was observed during the postspawning phase (8.4 0.9; P<0.001). Superfused slices of the POA ofC. batrachustreatedwith IST peptide resulted in a significant reduction in TH-immunoreactivity in the NPPa [Control: 45.3 4.2; IST peptide (5 M): 29.4 4.7; P<0.05]. We suggest that the intense interaction between IST and DA in the NPPa, most probably of the inhibitory nature, may be critical to the regulation of LH cells and reproduction in teleosts. This article is protected by copyright. All rights reserved.


PubMed | National Institute of Science Education and Research NISER Bhubaneswar, Tufts University and Rashtrasant Tukadoji Maharaj Nagpur University
Type: Journal Article | Journal: Neuropharmacology | Year: 2016

While dopamine (DA) neurons in the ventral tegmental area (VTA) drive the mesolimbic-reward pathway, confluent lines of evidence underscore the importance of transient receptor potential vanilloid (TRPV) channels as novel regulators of these neurons. Among the TRPV-subfamily, TRPV3 is of particular interest in reward, since active ingredients of flavour-enhancing spices in food serve as TRPV3 agonists and modulate DAergic neurotransmission. The nature of TRPV3 elements in the VTA and their role in driving the mesolimbic-DA-reward pathway has however, remained unexplored. We observed TRPV3 mRNA as well as TRPV3-immunoreactive neurons in the VTA of Wistar rats. We therefore explored whether these ion channels participate in modulating mesolimbic-DA reward pathway. In the posterior VTA (pVTA), 822.6% of the TRPV3 neurons co-express tyrosine hydroxylase and 685.5% of these neurons project to the nucleus accumbens shell (Acb shell). While exvivo treatment of midbrain slices with TRPV3-agonist, thymol increased [Ca(2+)]i-activity in pVTA neurons, intra-pVTA injections of thymol in freely-moving, satiated rats enhanced positive reinforcement for active lever pressings in an operant chamber to self-administer sweet pellets. This behavior was attenuated by prior treatment with intra-Acb shell DA D1- and D2-like receptor antagonists. These results demonstrate a role for TRPV3 in driving mesolimbic-DA food-reward pathway, and underscores the importance of these channels in the VTA as key components processing reward.


PubMed | National Institute of Science Education and Research NISER Bhubaneswar
Type: Journal Article | Journal: The journal of physical chemistry. A | Year: 2016

In recent research [ Chem. Commun. 2014 , 50 , 8667 ], it was found that photoinduced enolization occurred in 1,9-diformyl-5,5-diaryldipyrromethane (DA

Loading National Institute of Science Education and Research NISER Bhubaneswar collaborators
Loading National Institute of Science Education and Research NISER Bhubaneswar collaborators