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Ramirez-Sandoval J.C.,National Institute of Medical science and Nutrition Salvador Zubiran INCMNSZ | Castilla-Peon M.F.,Hospital Infantil de Mexico Federico Gomez | Gotes-Palazuelos J.,National Institute of Medical science and Nutrition Salvador Zubiran INCMNSZ | Vazquez-Garcia J.C.,National Institute of Respiratory Diseases INER | And 6 more authors.
High Altitude Medicine and Biology | Year: 2016

Ramirez-Sandoval, Juan C., Maria F. Castilla-Peón, José Gotés-Palazuelos, Juan C. Vázquez-García, Michael P. Wagner, Carlos A. Merelo-Arias, Olynka Vega-Vega, Rodolfo Rincón-Pedrero, and Ricardo Correa-Rotter. Bicarbonate values for healthy residents living in cities above 1500 m of altitude: a theoretical model and systematic review. High Alt Med Biol. 17:85-92, 2016. - Plasma bicarbonate (HCO3 -) concentration is the main value used to assess the metabolic component of the acid-base status. There is limited information regarding plasma HCO3 - values adjusted for altitude for people living in cities at high altitude defined as 1500 m (4921 ft) or more above sea level. Our aim was to estimate the plasma HCO3 - concentration in residents of cities at these altitudes using a theoretical model and compare these values with HCO3 - values found on a systematic review, and with those venous CO2 values obtained in a sample of 633 healthy individuals living at an altitude of 2240 m (7350 ft). We calculated the PCO2 using linear regression models and calculated plasma HCO3 - according to the Henderson-Hasselbalch equation. Results show that HCO3 - concentration falls as the altitude of the cities increase. For each 1000 m of altitude above sea level, HCO3 - decreases to 0.55 and 1.5 mEq/L in subjects living at sea level with acute exposure to altitude and in subjects acclimatized to altitude, respectively. Estimated HCO3 - values from the theoretical model were not different to HCO3 - values found in publications of a systematic review or with venous total CO2 measurements in our sample. Altitude has to be taken into consideration in the calculation of HCO3 - concentrations in cities above 1500 m to avoid an overdiagnosis of acid-base disorders in a given individual. © Copyright 2016, Mary Ann Liebert, Inc. 2016.

Ramirez H.,Institute of Agrobiotechnology | Ramirez H.,National Autonomous University of Mexico | Glaria I.,Institute of Agrobiotechnology | Andres X.D.,Institute of Agrobiotechnology | And 9 more authors.
Veterinary Journal | Year: 2011

Nucleotide sequences of small ruminant lentiviruses (SRLVs) were determined in sheep and goats, including progeny of imported animals, on a farm in Mexico. On the basis of gag-pol, pol, env and LTR sequences, SRLVs were assigned to the B1 subgroup, which comprises caprine arthritis-encephalitis virus (CAEV)-like prototype sequences mainly from goats. In comparison with CAEV. -like env sequences of American and French origin, two putative recombination events were identified within the V3-V4 and V4-V5 regions of the env gene of a full length SRLV sequence (FESC-752) derived from a goat on the farm. © 2010 Elsevier Ltd.

Rincon E.,CSIC - National Center for Biotechnology | Rincon E.,Institute Salud Carlos III | Gharbi S.I.,CSIC - National Center for Biotechnology | Santos-Mendoza T.,National Institute of Respiratory Diseases INER | Merida I.,CSIC - National Center for Biotechnology
Progress in Lipid Research | Year: 2012

Diacylglycerol (DAG) and phosphatidic acid (PA) are lipids with unique functions as metabolic intermediates, basic membrane constituents, and second-signal components. Diacylglycerol kinases (DGK) regulate the levels of these two lipids, catalyzing the interconversion of one to the other. The DGK family of enzymes is composed of 10 isoforms, grouped into five subfamilies based on the presence of distinct regulatory domains. From its initial characterization as a type IV DGK to the generation of mouse models showing its importance in cardiac dysfunction and immune pathologies, diacylglycerol kinase ζ (DGKζ) has proved an excellent example of the critical role of lipid-metabolizing enzymes in the control of cell responses. Although the mechanism that regulates this enzyme is not well known, many studies demonstrate its subtle regulation and its strategic function in specific signaling and as part of adaptor protein complexes. These data suggest that DGKζ offers new opportunities for therapeutic manipulation of lipid metabolism. © 2011 Elsevier Ltd. All rights reserved.

Perez-Padilla R.,National Institute of Respiratory Diseases INER | Wehrmeister F.C.,Federal University of Pelotas | Celli B.R.,Harvard University | Lopez-Varela M.V.,University of the Republic of Uruguay | And 7 more authors.
PLoS ONE | Year: 2013

QUESTION:A 6-second spirometry test is easier than full exhalations. We compared the reliability of the ratio of the Forced expiratory volume in 1 second/Forced expiratory volume in 6 seconds (FEV1/FEV6) to the ratio of the FEV1/Forced vital capacity (FEV1/FVC) for the detection of airway obstruction.METHODS:The PLATINO population-based survey in individuals aged 40 years and over designed to estimate the prevalence of post-Bronchodilator airway obstruction repeated for the same study participants after 5-9 years in three Latin-American cities.RESULTS:Using the FEV1/FVC

Guani-Guerra E.,Hospital Regional de Alta Especialidad del Bajio | Santos-Mendoza T.,National Institute of Respiratory Diseases INER | Lugo-Reyes S.O.,National Institute of Respiratory Diseases INER | Teran L.M.,National Institute of Respiratory Diseases INER
Clinical Immunology | Year: 2010

Antimicrobial peptides (AMPs) are evolutionarily conserved molecules involved in the defense mechanisms of a wide range of organisms. Produced in bacteria, insects, plants and vertebrates, AMPs protect against a broad array of infectious agents. In mammals these peptides protect against bacteria, viruses, fungi, and certain parasites. Recently, novel biologic effects of AMPs have been documented such as endotoxin neutralization, chemotactic and immunomodulating activities, induction of angiogenesis and wound repair. Thus these ancestral molecules are crucial components of the innate immune system and attractive candidates for novel therapeutic approaches. This review focuses on cathelicin and defensins, the most documented human AMPs, and discusses their antimicrobial activity and pleiotropic immunomodulating effects on inflammatory and infectious diseases. © 2009 Elsevier Inc. All rights reserved.

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