National Institute of Rehabilitation

Mexico City, Mexico

National Institute of Rehabilitation

Mexico City, Mexico
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Perez-Santos M.,Autonomous University of Puebla | Anaya-Ruiz M.,Instituto Mexicano del Seguro Social | Bandala C.,National Institute of Rehabilitation
Recent Patents on Anti-Cancer Drug Discovery | Year: 2017

Background: Data mining publications and patent data can provide decision support for scientists, inventors and industry in the field of cancer research. Objective: The main objective of this article it to identify trends of research and patent generation productivity originating from Latin American countries in the field of cancer. Method: Publications were collected from the Scopus, Web of Science, PubMed database; and patents were collected from Latipat Espacenet databases. Data from January 1, 2000 until December 31, 2014 were searched for documents with specific words in cancer as a “topic” and a list of 20 Latin American countries as affiliation country. Results: A total of 12,989 items published and 244 patent applications including “cancer” were retrieved. Brazil, Mexico, Argentina, Chile and Peru were highest contributors in cancer research, while Brazil, Mexico, Cuba and Argentina were highest contributors in cancer patent applications. Conclusion: The analysis of the data from this study provides an overview of research and patent activity in Latin America in the cancer field, which can be useful to help health policy makers and people in academia to shape up cancer research in the future. © 2017 Bentham Science Publishers.

STUDY DESIGN:Observational, descriptive, transversal.OBJECTIVES:To evaluate the validity and reliability of spatio-temporal gait parameters measured by GaitRite in motor incomplete spinal cord-injured (SCI) patients.SETTING:National Institute of Rehabilitation, Mexico city.METHODS:23 motor subacute and chronic incomplete SCI American Spinal Cord Injury Association Impairment Scale (AIS) D subjects were measured. The 10-meter walking test (10 MWT), 6-minute walking test (6 MWT), Walking Index for Spinal Cord Injury II (WISCI-II), Spinal Cord Independence Measure III (SCIM-III) and the GaitRite evaluation were carried out concurrently in order to determine validity. The 10 MWT and GaitRite evaluation were performed at different occasions in order to determine test–retest reliability.RESULTS:GaitRite offers a valid and reliable way to measure the mobility, symmetry and stability characteristics of gait SCI subjects. GaitRite precision and sensitivity is approximately three times better than clinical tests. Clinical tests cannot address the stability properties of gait. Subjects’ higher gait velocity is related to more independence (SCIM-III), lower use of walking aids (WISCI-II), better performance in lower extremities motor score (LEMS) and better gait’s mobility.CONCLUSIONS:Spatio-temporal gait parameters measured by GaitRite are both valid and reliable. Further studies are necessary to establish sensitivity of the instrument.Spinal Cord advance online publication, 28 February 2017; doi:10.1038/sc.2017.4. © 2017 International Spinal Cord Society

Martinez-Cruz C.F.,National Institute of Perinatology | Poblano A.,National Institute of Rehabilitation | Garcia-Alonso Themann P.,National Institute of Perinatology
International Journal of Pediatric Otorhinolaryngology | Year: 2017

Objective Newborns from Neonatal intensive care units (NICU) are at high-risk for sensorineural hearing loss (SNHL) a follow-up is needed for early diagnosis and intervention. Our objective here was to describe the features and changes of SNHL at different periods during a follow-up of almost 20 years. Methods Risk factors for SNHL during development were analyzed. The audiological examination included: Brainstem auditory evoked potentials (BAEP), and Transient evoked otoacoustic emissions (TEOAE). At birth; tonal audiometry (between 125 and 8000 Hz), and tympanometry were performed at 5, 10, 15, and 20 years of age. Results Sixty-five percent of cases presented bilateral absence of BAEP. At 5 years of age, the most frequent SNHL level was severe (42.5%), followed by moderate (22.5%), and profound level (20%), in all cases, the SNHL was symmetrical with a predominance of lesion for the high frequencies. Exchange transfusion was associated with a higher degree of SNHL (OR = 6.00, CI = 1.11–32.28, p < 0.02). In 55%, SNHL remained stable, but in 40% of the cases it was progressive. At the end of the study six cases with moderate loss progressed to the severe level and seven cases with severe level progressed to profound. Conclusions Forty percent of infants with SNHL discharged from NICU may present a progression in the hearing loss. Exchange transfusion was associated with a higher degree of SNHL. NICU graduates with SNHL merit a long-term audiological follow-up throughout their lifespan. © 2017

Iliescu R.I.,Polytechnic University of Bucharest | Andronescu E.,Polytechnic University of Bucharest | Ghitulica C.D.,Polytechnic University of Bucharest | Voicu G.,Polytechnic University of Bucharest | And 2 more authors.
International Journal of Pharmaceutics | Year: 2014

The scope of the present study was the preparation and characterization of irinotecan nanocomposite beads based on montmorillonite (Mt) and sodium alginate (AL) as drug carriers. After irinotecan (I) incorporation into Mt, the resulting hybrid was compounded with alginate, and I-Mt-AL nanocomposite beads were obtained by ionotropic gelation technique. The structure and surface morphology of the hybrid and composite materials were established by means of X-ray diffraction (XRD), IR spectroscopy (FT-IR), thermal analysis (TG-DTA) and scanning electron microscopy (SEM). Irinotecan incorporation efficiency in Mt and in alginate beads was determined both by UV-vis spectroscopy and thermal analysis and was found to be high. The hybrid and composite materials were tested in vitro in simulated intestinal fluid (pH 7.4, at 37 C) in order to establish if upon administering the beads at the site of a resected colorectal tumor, the delivery of the drug is sustained and can represent an alternative to the existing systemic chemotherapy. The in vitro drug release test results clearly suggested that Mt, and Mt along with AL were able to control the release of irinotecan by making it sustained, without any burst effect, and by reducing the released amount and the release rate. The nanocomposite beads may be a promising drug delivery system in chemotherapy. © 2013 Elsevier B.V.

Navarro-Zarza J.E.,Hospital General Of Chilpancingo Dr Raymundo Abarca Alarcon | Hernandez-Diaz C.,National Institute of Rehabilitation | Saavedra M.A.,National Autonomous University of Mexico | Alvarez-Nemegyei J.,Mayab University | And 2 more authors.
Arthritis Care and Research | Year: 2014

Objective To report the baseline knowledge of clinical anatomy of rheumatology fellows and rheumatologists from Argentina, Chile, Ecuador, El Salvador, Mexico, the US, and Uruguay. Methods The invitation to attend a workshop in clinical anatomy was an open call by national rheumatology societies in 4 countries or by invitation from teaching program directors in 3 countries. Prior to the workshop, a practical test of anatomic structures commonly involved in rheumatic diseases was administered. The test consisted of the demonstration of these structures or their function in the participant's or instructor's body. At one site, a postworkshop practical test was administered immediately after the workshop. Results There were 170 participants (84 rheumatology fellows, 61 rheumatologists, and 25 nonrheumatologists). The overall mean ± SD number of correct answers was 46.6% ± 19.9% and ranged from 32.5-67.0% by country. Rheumatology fellows scored significantly higher than nonrheumatologists. Questions related to anatomy of the hand scored the lowest of the regions surveyed. Conclusion Rheumatology fellows and rheumatologists showed a deficit in knowledge of musculoskeletal anatomy that is of central importance in rheumatologic assessment and diagnosis. This gap may hinder accurate and cost-effective rheumatologic diagnosis, particularly in the area of regional pain syndromes. Presently, widespread use of musculoskeletal ultrasound (MSUS) by rheumatologists may be premature, since a key component of expert-level MSUS is the integration of an accurate knowledge of anatomy with the views obtained with the ultrasound probe. Copyright © 2014 by the American College of Rheumatology.

Uribe-Escamilla R.,National Institute of Rehabilitation | Poblano A.,National Institute of Rehabilitation | Alfaro-Rodriguez A.,National Institute of Rehabilitation
Egyptian Journal of Ear, Nose, Throat and Allied Sciences | Year: 2013

Amplitude measurement and reproducibility of Transient-otoacoustic emissions (T-EOAE) depend on synchronicity and functional integrity of cochlear outer hair cells, thus, the main objective of this study was to determine the usefulness of amplitude measurement and reproducibility in five selective frequencies of T-EOAE in patients with Sensorineural hearing loss (SNHL). We studied 44 subjects with SNHL by means of T-EOAE and Brainstem auditory evoked potentials (BAEP), and compared the results with those of a six control-normal-hearing subject group. We observed significant differences in the reproducibility of T-EOAE and in amplitudes of 0.7, 1.5, 2.2, 3.0 and 3.7. kHz. In addition, we observed negative significant correlations between BAEP threshold and T-EOAE reproducibility and with all specific amplitude measurement frequency values. These results confirm the clinical usefulness of reproducibility and selective amplitude measurement of frequency of T-EOAE for SNHL identification. © 2013 .

Rogojan R.,National Institute of Rehabilitation | Andronescu E.,Polytechnic University of Bucharest | Ghitulica C.,Polytechnic University of Bucharest | Stefan Vasile B.,Polytechnic University of Bucharest
UPB Scientific Bulletin, Series B: Chemistry and Materials Science | Year: 2011

It is known that sol-gel method is an alternative method to produce ceramic powders. The present study deals with the synthesis and characterization of Al2O3 nanopowders which can be a potentially utilized material for biocompatible implants.[1,2,3,4] Based on sol-gel method, the synthesis started from different chemical nature precursors - inorganic (aluminum chloride, AlCl3) and organic (aluminum triisopropylate, (C3H7O) 2)Al). The powders obtained after drying the gel were heat treated at 1000°C and 1200°C for 2 hours. X-ray diffraction was used in order to characterize the powders in terms of their crystallinity degree and crystallite size. Microstructural and morphological characterization was performed using electron-microscopic techniques - scanning electron microscopy (SEM) and transmission electron microscopy (TEM).

Zambrano-Sanchez E.,National Institute of Rehabilitation | Martinez-Cortes J.A.,Neurologist | del Rio-Carlos Y.,Psychiatrist | Dehesa-Moreno M.,Psychiatrist | Poblano A.,National Institute of Rehabilitation
Arquivos de Neuro-Psiquiatria | Year: 2012

Objective: Attention deficit hyperactivity disorder (ADHD) is an alteration that begins early in infancy and whose cardinal symptoms are inattention, hyperactivity and impulsivity. There are few studies for specific tests to measure Quality of Life (QoL) in children with ADHD. Methods: We evaluated QoL of 120 children from 7-12 years of age with ADHD and of a group of 98 healthy control children. To measure QoL, we utilized the Questionnaire of Quality of Life for Children in Pictures (AutoQuestionnaire Qualité de Vie Enfant Imagé, AUQUEI). We evaluated anxiety in children by the Childreńs Manifest Anxiety Scale-Revisited (CMAS-R). We compared results among groups and employed the calculation of correlation between the AUQUEI questionnaire and the CMAS-R scale. Results: The total average of the AUQUEI questionnaire in children with ADHD was 45.2, while in the control group it was 54.3 (p<0.05). We also observed significant differences between the control group and groups of children with ADHD in the CMAS-R scale. We found significant correlations between AUQUEI questionnaire and CMAS-R scale. Conclusion: The main result was to the disclosure that low QoL scores in ADHD children was anxiety-related.

Konstantinidis C.,National Institute of Rehabilitation | Samarinas M.,General Hospital Koutlibanio of Larisa | Andreadakis S.,General Clinic | Xanthis S.,General Hospital Koutlibanio of Larisa | Skriapas K.,General Hospital Koutlibanio of Larisa
Urologia Internationalis | Year: 2013

Objective: To evaluate the efficacy and safety of fesoterodine extended-release (ER) plus tamsulosin in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Patients and Methods: Men aged ≥50 years, with LUTS, prostate volume ≤60 ml and International Prostate Symptom Score (IPSS) ≥13 were enrolled in this study. 173 consecutive patients were treated initially with tamsulosin (0.4 mg) for 1 week. At the second visit, 47 patients out of the sample of 173 who were still experiencing inconvenient LUTS were randomized into two groups. The first group received a therapy with tamsulosin and fesoterodine combination (group 1, n = 24) while the second continued the therapy with the single administration of tamsulosin (group 2, n = 23) for an additional 4-week period. Results: There was no statistically significant difference in age, prostate volume, Q max, and postvoid residual urine between the two groups. A statistical significance appeared in the combination group regarding the storage and the total IPSS values among the second and third visits (10.5 ± 1.4 to 8.5 ± 1.3 and 16.1 ± 1.8 to 13.7 ± 1.5 respectively). Conclusion: Regarding bothersome LUTS and storage symptoms, fesoterodine ER and tamsulosin combination was significantly more effective than the single administration of tamsulosin. Copyright © 2012 S. Karger AG, Basel.

Cardenas-Rodriguez N.,National Institute of Pediatrics | Huerta-Gertrudis B.,National Institute of Pediatrics | Rivera-Espinosa L.,National Institute of Pediatrics | Montesinos-Correa H.,National Institute of Pediatrics | And 3 more authors.
International Journal of Molecular Sciences | Year: 2013

Oxidative stress, a state of imbalance in the production of reactive oxygen species and nitrogen, is induced by a wide variety of factors. This biochemical state is associated with systemic diseases, and diseases affecting the central nervous system. Epilepsy is a chronic neurological disorder with refractoriness to drug therapy at about 30%. Currently, experimental evidence supports the involvement of oxidative stress in seizures, in the process of their generation, and in the mechanisms associated with refractoriness to drug therapy. Hence, the aim of this review is to present information in order to facilitate the handling of this evidence and determine the therapeutic impact of the biochemical status for this pathology. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

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