Entity

Time filter

Source Type


Narva S.,Birla Institute of Technology and Science | Chitti S.,Birla Institute of Technology and Science | Bala B.R.,Indian Institute of Chemical Technology | Alvala M.,National Institute of Pharmaceutical Education and Research, Hyderabad | And 2 more authors.
European Journal of Medicinal Chemistry | Year: 2016

A series of thirty two novel pyrrolo[2,3-b]pyridine analogues synthesized, characterized (1H NMR, 13C NMR and MS) and cytotoxic evaluation of these molecules carried out over a panel of three human cancer cell lines including A549 (lung cancer), HeLa (cervical cancer) and MDA MB-231 (breast cancer), using sulforhodamine B assay method. Few molecules such as 5c, 5d, 5e, 5h, 5k, 5m, 5n, 5q, 5r, 7f, 7j, 7g and 7k exhibited maximum growth inhibitory action against the tested cancer cell lines at lower micro molar concentration. Noticeably, compounds exhibited good growth inhibition in all three cancer cell lines in the range of 0.12 μM-9.84 μM. Further study exposed that one of the active compound 5d could efficiently intercalate into calf thymus DNA to form 5d-DNA complex which might block DNA replication to influence their antiproliferative activity. The molecular interactions of all the synthesized analogs were also supported by molecular docking simulations. We believe that further optimization of these compounds will lead to potential anticancer agents. © 2016 Elsevier Masson SAS. All rights reserved. Source


National Institute of Pharmaceutical Education and Research, Hyderabad | Entity website

From a modest beginning in 2007, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad has now grown into a fully integrated global pharmaceutical education and research institute. The guiding philosophy of the institute, throughout, has been creation of knowledge, influencing Pharmaceutical fields that integrates globally ...


National Institute of Pharmaceutical Education and Research, Hyderabad | Entity website

Hostels The students of NIPER-Hyderabad have been provided accommodation at NIPER hostel located at IDPL Township, around 2 kms away from NIPER campus situated in Balanagar, Hyderabad. Students are provided with to and fro bus service between the Institute and Hostel ...


National Institute of Pharmaceutical Education and Research, Hyderabad | Entity website

Activity Dates Semester I & III (July to December, 2015) Commencement of semester 27th July 2015 Comprehensive Examination for Ph.D ...


National Institute of Pharmaceutical Education and Research, Hyderabad | Entity website

Dr. Srinivas R is the Dean and course coordinator for Pharmaceutical Analysis department ...

Discover hidden collaborations