National Institute of Pharmaceutical Education and Research, Hyderabad

www.niperhyd.ac.in
Hyderabad, India

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Areti A.,National Institute of Pharmaceutical Education and Research, Hyderabad | Yerra V.G.,National Institute of Pharmaceutical Education and Research, Hyderabad | Naidu V.G.M.,National Institute of Pharmaceutical Education and Research, Hyderabad | Kumar A.,National Institute of Pharmaceutical Education and Research, Hyderabad
Redox Biology | Year: 2014

Peripheral neuropathy is a severe dose limiting toxicity associated with cancer chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying chemotherapy induced peripheral neuropathy (CIPN) remain sparse and considerable involvement of oxidative stress and neuroinflammation has been realized recently. Despite the empirical use of antioxidants in the therapy of CIPN, the oxidative stress mediated neuronal damage in peripheral neuropathy is still debatable. The current review focuses on nerve damage due to oxidative stress and mitochondrial dysfunction as key pathogenic mechanisms involved in CIPN. Oxidative stress as a central mediator of apoptosis, neuroinflammation, metabolic disturbances and bioenergetic failure in neurons has been highlighted in this review along with a summary of research on dietary antioxidants and other nutraceuticals which have undergone prospective controlled clinical trials in patients undergoing chemotherapy. © 2014 The Authors.


Narva S.,Birla Institute of Technology and Science | Chitti S.,Birla Institute of Technology and Science | Bala B.R.,Indian Institute of Chemical Technology | Alvala M.,National Institute of Pharmaceutical Education and Research, Hyderabad | And 2 more authors.
European Journal of Medicinal Chemistry | Year: 2016

A series of thirty two novel pyrrolo[2,3-b]pyridine analogues synthesized, characterized (1H NMR, 13C NMR and MS) and cytotoxic evaluation of these molecules carried out over a panel of three human cancer cell lines including A549 (lung cancer), HeLa (cervical cancer) and MDA MB-231 (breast cancer), using sulforhodamine B assay method. Few molecules such as 5c, 5d, 5e, 5h, 5k, 5m, 5n, 5q, 5r, 7f, 7j, 7g and 7k exhibited maximum growth inhibitory action against the tested cancer cell lines at lower micro molar concentration. Noticeably, compounds exhibited good growth inhibition in all three cancer cell lines in the range of 0.12 μM-9.84 μM. Further study exposed that one of the active compound 5d could efficiently intercalate into calf thymus DNA to form 5d-DNA complex which might block DNA replication to influence their antiproliferative activity. The molecular interactions of all the synthesized analogs were also supported by molecular docking simulations. We believe that further optimization of these compounds will lead to potential anticancer agents. © 2016 Elsevier Masson SAS. All rights reserved.


Mallavadhani U.V.,Indian Institute of Chemical Technology | Prasad C.V.,Indian Institute of Chemical Technology | Shrivastava S.,National Institute of Pharmaceutical Education and Research, Hyderabad | Naidu V.G.M.,National Institute of Pharmaceutical Education and Research, Hyderabad
European Journal of Medicinal Chemistry | Year: 2014

Six novel 5,6-fused hybrids such as dihydrobenzofuran-quinone (4a and 4b), benzofuran-quinone (5a and 5b) and chromene-quinone (6a and 6b) of juglone based 1,4-naphthoquinones were synthesized by employing a three step protocol with the cyclisation of o-allyl phenol as the key step. The anticancer activity of the newly synthesized compounds was evaluated in vitro against seven human cancer cell lines including cervix (ME-180 and HeLa), breast (MCF-7, MDA-MB-453 and MDA-MB-231), prostate (PC-3) and colon (HT-29) by using MTT assay. The screening results showed that majority of the synthesized compounds exhibited significant anticancer activity. In particular, compounds 6a and 6b showed potent activities than the standard drug etoposide against prostate and breast cancer cell lines respectively. Flow cytometric analysis revealed that compounds 6a and 6b induced apoptosis and arrested the cell cycle at G2/M phase in PC-3 and MDA-MB-453 cells respectively. © 2014 Elsevier Masson SAS. All rights reserved.


National Institute of Pharmaceutical Education and Research, Hyderabad | Entity website

Activity Dates Semester I & III (July to December, 2015) Commencement of semester 27th July 2015 Comprehensive Examination for Ph.D ...


PubMed | Indian Institute of Chemical Technology, National Institute of Pharmaceutical Education and Research, Hyderabad and Birla Institute of Technology and Science
Type: | Journal: European journal of medicinal chemistry | Year: 2016

A series of thirty two novel pyrrolo[2,3-b]pyridine analogues synthesized, characterized ((1)H NMR, (13)C NMR and MS) and cytotoxic evaluation of these molecules carried out over a panel of three human cancer cell lines including A549 (lung cancer), HeLa (cervical cancer) and MDA MB-231 (breast cancer), using sulforhodamine B assay method. Few molecules such as 5c, 5d, 5e, 5h, 5k, 5m, 5n, 5q, 5r, 7f, 7j, 7g and 7k exhibited maximum growth inhibitory action against the tested cancer cell lines at lower micro molar concentration. Noticeably, compounds exhibited good growth inhibition in all three cancer cell lines in the range of 0.12M-9.84M. Further study exposed that one of the active compound 5d could efficiently intercalate into calf thymus DNA to form 5d-DNA complex which might block DNA replication to influence their antiproliferative activity. The molecular interactions of all the synthesized analogs were also supported by molecular docking simulations. We believe that further optimization of these compounds will lead to potential anticancer agents.


PubMed | Indian Institute of Chemical Technology and National Institute of Pharmaceutical Education and Research, Hyderabad
Type: | Journal: European journal of medicinal chemistry | Year: 2014

Six novel 5,6-fused hybrids such as dihydrobenzofuran-quinone (4a and 4b), benzofuran-quinone (5a and 5b) and chromene-quinone (6a and 6b) of juglone based 1,4-naphthoquinones were synthesized by employing a three step protocol with the cyclisation of o-allyl phenol as the key step. The anticancer activity of the newly synthesized compounds was evaluated invitro against seven human cancer cell lines including cervix (ME-180 and HeLa), breast (MCF-7, MDA-MB-453 and MDA-MB-231), prostate (PC-3) and colon (HT-29) by using MTT assay. The screening results showed that majority of the synthesized compounds exhibited significant anticancer activity. In particular, compounds 6a and 6b showed potent activities than the standard drug etoposide against prostate and breast cancer cell lines respectively. Flow cytometric analysis revealed that compounds 6a and 6b induced apoptosis and arrested the cell cycle at G2/M phase in PC-3 and MDA-MB-453 cells respectively.


PubMed | National Institute of Pharmaceutical Education and Research, Hyderabad
Type: | Journal: Redox biology | Year: 2014

Peripheral neuropathy is a severe dose limiting toxicity associated with cancer chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying chemotherapy induced peripheral neuropathy (CIPN) remain sparse and considerable involvement of oxidative stress and neuroinflammation has been realized recently. Despite the empirical use of antioxidants in the therapy of CIPN, the oxidative stress mediated neuronal damage in peripheral neuropathy is still debatable. The current review focuses on nerve damage due to oxidative stress and mitochondrial dysfunction as key pathogenic mechanisms involved in CIPN. Oxidative stress as a central mediator of apoptosis, neuroinflammation, metabolic disturbances and bioenergetic failure in neurons has been highlighted in this review along with a summary of research on dietary antioxidants and other nutraceuticals which have undergone prospective controlled clinical trials in patients undergoing chemotherapy.


National Institute of Pharmaceutical Education and Research, Hyderabad | Entity website

Student Life NIPER-Hyderabad home buzzes with conversation, bustles with events, and nurtures new ideas. Rounding out rigorous academic activity are soaring reading rooms, breathtaking chapels, plentiful playing fields, and beautiful landscape in gardens to explore ...


National Institute of Pharmaceutical Education and Research, Hyderabad | Entity website

Syllabi Here you can download the syllabus of individual course of M.S (Pharm), M ...


National Institute of Pharmaceutical Education and Research, Hyderabad | Entity website

From a modest beginning in 2007, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad has now grown into a fully integrated global pharmaceutical education and research institute. The guiding philosophy of the institute, throughout, has been creation of knowledge, influencing Pharmaceutical fields that integrates globally ...

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