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Wasnik K.,National Institute of Pharmaceutical Education and Research, Hajipur
International Journal of Pharma and Bio Sciences | Year: 2011

Although treatments for AIDS and HIV can slow the course of the disease, there is currently no vaccine or cure. Antiretroviral treatment reduces both the mortality and the morbidity of HIV infection, but these drugs are expensive and routine access to antiretroviral medication is not available in all countries. Due to the difficulty in treating HIV infection, preventing infection is a key aim in controlling the AIDS pandemic, with health organizations promoting safe sex and needle-exchange programmes in attempts to slow the spread of the virus. RANTES was shown to be the most potent member of a trio of CC chemokines released by CD8+ T cells that were able to suppress the replication of non-syncitium-inducing (NSI) HIV-1 strains in vitro the others were macrophage inflammatory protein 1 α (MIP-1α) and MIP-1β. Some studies in vivo have supported a role for RANTES in HIV suppression, with the demonstration of unusually high levels of RANTES production in both HIV exposed humans and vaccinated monkeys who appear to be resistant to infection with HIV or simian immunodeficiency virus (SIV). These encouraging observations have led to further studies to test the potential therapeutic use of RANTES, both in the treatment and prevention of HIV infection.


PubMed | National Institute of Pharmaceutical Education and Research, Hajipur
Type: Journal Article | Journal: Journal of enzyme inhibition and medicinal chemistry | Year: 2010

A four-feature 3D-pharmacophore model was built from a set of 24 compounds whose activities were reported against the V1/S strain of the Plasmodium falciparum dihydrofolate reductase (PfDHFR) enzyme. This is an enzyme harboring Asn51Ile + Cys59Arg + Ser108Asn + Ile164Leu mutations. The HipHop module of the Catalyst program was used to generate the model. Selection of the best model among the 10 hypotheses generated by HipHop was carried out based on rank and best-fit values or alignments of the training set compounds onto a particular hypothesis. The best model (hypo1) consisted of two H-bond donors, one hydrophobic aromatic, and one hydrophobic aliphatic features. Hypo1 was used as a query to virtually screen Maybridge2004 and NCI2000 databases. The hits obtained from the search were subsequently subjected to FlexX and Glide docking studies. Based on the binding scores and interactions in the active site of quadruple-mutant PfDHFR, a set of nine hits were identified as potential inhibitors.


National Institute of Pharmaceutical Education and Research, Hajipur | Entity website


National Institute of Pharmaceutical Education and Research, Hajipur | Entity website

Rajendra Memorial Research Institute of Medical Sciences is the mentor institute for NIPER,Hajipur-Vaishali. It is a Premier Research Institute of Indian Council of Medical Research, under administrative control of Ministry of Health and Family Welfare, Government of India ...


National Institute of Pharmaceutical Education and Research, Hajipur | Entity website

National lnstitute of Pharmaceutical Education and Research (NIPER Hajipur, Vaishali) An autonomous institution established under Department of Chemical and Petrochemicals, Ministry of Chemicals and Fertilizers Export Promotion Industrial Park (EPIP) Zandaha Road, Hajipur, Vaishali 844102 Fax : 06224 - 277225 Tel : 06224 - 277226 06224 - 277224 06224 - 277229 Email : niper.hajipur2007@gmail ...


National Institute of Pharmaceutical Education and Research, Hajipur | Entity website

Tender Notice for Hiring on rent a 125 KVA Diesel Generator at NIPER, EPIP Campus, Hajipur (Vaishali), Bihar latest by 16/05/2016 at 1.00 P ...


National Institute of Pharmaceutical Education and Research, Hajipur | Entity website

Pharmacy Practice: It is a health specialty, which describes the activities and services of the clinical pharmacist to develop and promote the rational and appropriate use of medicinal products and devices. NIPER-Hajipur Pharmacy Practice faculty offers innovative education and delivers high impact research ...


National Institute of Pharmaceutical Education and Research, Hajipur | Entity website


National Institute of Pharmaceutical Education and Research, Hajipur | Entity website


National Institute of Pharmaceutical Education and Research, Hajipur | Entity website

The National Institute of Pharmaceutical Education and Research,Hajipur (NIPER Hajipur) was established in 2007 by Department ofPharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India. NIPER came up as a center of excellence for higher education and research in pharmaceutical sciences ...

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