National Institute of Nutrition and Health

Beijing, China

National Institute of Nutrition and Health

Beijing, China
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Liu X.,National Institute of Nutrition and Health | Zhang Y.,National Institute of Nutrition and Health | Piao J.,National Institute of Nutrition and Health | Mao D.,National Institute of Nutrition and Health | And 4 more authors.
Nutrients | Year: 2017

The development of reference values of trace elements is recognized as a fundamental prerequisite for the assessment of trace element nutritional status and health risks. In this study, a total of 1400 pregnant women aged 27.0 ± 4.5 years were randomly selected from the China Nutrition and Health Survey 2010-2012 (CNHS 2010-2012). The concentrations of 14 serum trace elements were determined by high-resolution inductively coupled plasma mass spectrometry. Reference values were calculated covering the central 95% reference intervals (P2.5-P97.5) after excluding outliers by Dixon’s test. The overall reference values of serum trace elements were 131.5 (55.8-265.0 µg/dL for iron (Fe), 195.5 (107.0-362.4) µg/dL for copper (Cu), 74.0 (51.8-111.3) µg/dL for zinc (Zn), 22.3 (14.0-62.0) µg/dL for rubidium (Rb), 72.2 (39.9-111.6) µg/L for selenium (Se), 45.9 (23.8-104.3) µg/L for strontium (Sr), 1.8 (1.2-3.6) µg/L for molybdenum (Mo), 2.4 (1.2-8.4) µg/L for manganese (Mn), 1.9 (0.6-9.0) ng/L for lead (Pb), 1.1 (0.3-5.6) ng/L for arsenic (As), 835.6 (219.8-4287.7) ng/L for chromium (Cr), 337.9 (57.0-1130.0) ng/L for cobalt (Co), 193.2 (23.6-2323.1) ng/L for vanadium (V), and 133.7 (72.1-595.1) ng/L for cadmium (Cd). Furthermore, some significant differences in serum trace element reference values were observed between different groupings of age intervals, residences, anthropometric status, and duration of pregnancy. We found that serum Fe, Zn, and Se concentrations significantly decreased, whereas serum Cu, Sr, and Co concentrations elevated progressively compared with reference values of 14 serum trace elements in pregnant Chinese women. The reference values of serum trace elements established could play a key role in the following nutritional status and health risk assessment. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.


Li Y.,Harvard University | Wang D.D.,Harvard University | Ley S.H.,Harvard University | Howard A.G.,University of North Carolina at Chapel Hill | And 4 more authors.
Journal of the American College of Cardiology | Year: 2016

Background Cardiovascular disease (CVD) is a leading cause of death in China. Evaluation of risk factors and their impacts on disease burden is important for future public health initiatives and policy making. Objectives The study used data from a cohort of the China Health and Nutrition Survey to estimate time trends in cardiovascular risk factors from 1991 to 2011. Methods We applied the comparative risk assessment method to estimate the number of CVD events attributable to all nonoptimal levels (e.g., theoretical-minimum-risk exposure distribution [TMRED]) of each risk factor. Results In 2011, high blood pressure, high low-density lipoprotein cholesterol, and high blood glucose were associated with 3.1, 1.4, and 0.9 million CVD events in China, respectively. Increase in body mass index was associated with an increase in attributable CVD events, from 0.5 to 1.1 million between 1991 and 2011, whereas decreased physical activity was associated with a 0.7-million increase in attributable CVD events. In 2011, 53.4% of men used tobacco, estimated to be responsible for 30.1% of CVD burden in men. Dietary quality improved, but remained suboptimal; mean intakes were 5.4 (TMRED: 2.0) g/day for sodium, 67.7 (TMRED: 300.0) g/day for fruits, 6.2 (TMRED: 114.0) g/day for nuts, and 25.0 (TMRED: 250.0) mg/day for marine omega-3 fatty acids in 2011. Conclusions High blood pressure remains the most important individual risk factor related to CVD burden in China. Increased body mass index and decreased physical activity were also associated with the increase in CVD burden from 1991 to 2011. High rates of tobacco use in men and unhealthy dietary factors continue to contribute to the burden of CVD in China. © 2016 American College of Cardiology Foundation


PubMed | Peoples Hospital of Beijing University, Capital Medical University, National Institute of Nutrition and Health and U.S. Center for Disease Control and Prevention
Type: Journal Article | Journal: Biomedical and environmental sciences : BES | Year: 2016

Iron deficiency anemia is one of the most prevalent nutritional deficiency worldwide. The commonly used cut-off values for identifying iron deficiency are extrapolated from older children and may not be suitable for infants. Therefore, our study aimed to establish appropriate cut-off values for the evaluation of iron status in Chinese infants. Pregnant women who delivered at 37 gestational weeks with normal iron status were recruited. Later, infants with normal birth weight and who were breastfed in the first 4 months were selected. Blood samples were collected to assess hemoglobin, serum ferritin, soluble transferrin receptor, mean corpuscular volume and free erythrocyte protoporphyrin. Cut-offs of all iron indices were determined as the limit of 95% confidence interval.


Remya M.,Aarupadai Veedu Institute of Technology | Ananthan R.,National Institute of Nutrition and Health | Sivasankar S.,Aarupadai Veedu Institute of Technology
International Journal of Pharma and Bio Sciences | Year: 2013

Antioxidant effects of the Petroleum ether extracts of the leaves of Calotrois procera were tested on the basis of scavenging activity of the free radical DPPH (1, 1-diphenyl-2-picryl-hydrazyl), reducing power and inhibition of nitric oxide radical. The Petroleum Ether extracts of C.procera showed the highest antioxidant activity and the activity of the extract increased with increasing concentration. The total phenolic content of the leaf extract was found to be 38.23 μg pyrocatechol equivalents. Qualitative determination of 10 polyphenols (Gallic acid, 3,4 Dihy droxy B-acid, Epi_GC Gallate, p-Coumaric acid, Ellagic acid, Quercetin, Apigenin, Hesperitin, Luteoline, Kaempherol) was made using UPLC.


Yun C.,National Institute of Nutrition and Health | Chen J.,National Institute of Nutrition and Health | He Y.,National Institute of Nutrition and Health | Mao D.,National Institute of Nutrition and Health | And 5 more authors.
Public Health Nutrition | Year: 2015

Objective: To evaluate vitamin D deficiency prevalence and risk factors among pregnant Chinese women. Design: A descriptive cross-sectional analysis. Setting: China National Nutrition and Health Survey (CNNHS) 2010–2013. Subjects: A total of 1985 healthy pregnant women participated. Possible predictors of vitamin D deficiency were evaluated via multiple logistic regression analyses. Results: The median serum 25-hydroxyvitamin D level was 15·5 (interquartile range 11·9–20·0, range 3·0–51·5) ng/ml, with 74·9 (95 % CI 73·0, 76·7) % of participants being vitamin D deficient (25-hydroxyvitamin D <20 ng/ml). According to the multivariate logistic regression analyses, vitamin D deficiency was positively correlated with Hui ethnicity (P=0·016), lack of vitamin D supplement use (P=0·021) and low ambient UVB level (P<0·001). In the autumn months, vitamin D deficiency was related to Hui ethnicity (P=0·012) and low ambient UVB level (P<0·001). In the winter months, vitamin D deficiency was correlated with younger age (P=0·050), later gestational age (P=0·035), higher pre-pregnancy BMI (P=0·019), low ambient UVB level (P<0·001) and lack of vitamin D supplement use (P=0·007). Conclusions: Vitamin D deficiency is prevalent among pregnant Chinese women. Residing in areas with low ambient UVB levels increases the risk of vitamin D deficiency, especially for women experiencing advanced stages of gestation, for younger pregnant women and for women of Hui ethnicity; therefore, vitamin D supplementation and sensible sun exposure should be encouraged, especially in the winter months. Further studies must determine optimal vitamin D intake and sun exposure levels for maintaining sufficient vitamin D levels in pregnant Chinese women. Copyright © The Authors 2015


PubMed | Hong Kong Baptist University, National Institute of Nutrition and Health and Ministry of Health and China National Center for Food Safety Risk Assessment
Type: | Journal: Scientific reports | Year: 2016

Perfluoroalkyl substances (PFASs) have been detected in wildlife and human samples worldwide. Toxicology research showed that PFASs could interfere with thyroid hormone homeostasis. In this study, eight PFASs, fifteen PFAS precursors and five thyroid hormones were analyzed in 157 paired maternal and cord serum samples collected in Beijing around delivery. Seven PFASs and two precursors were detected in both maternal and cord sera with significant maternal-fetal correlations (r=0.336 to 0.806, all P<0.001). The median ratios of major PFASs concentrations in fetal versus maternal serum were from 0.25:1 (perfluorodecanoic acid, PFDA) to 0.65:1 (perfluorooctanoic acid, PFOA). Spearman partial correlation test showed that maternal thyroid stimulating hormone (TSH) was negatively correlated with most maternal PFASs (r=-0.261 to -0.170, all P<0.05). Maternal triiodothyronin (T3) and free T3 (FT3) showed negative correlations with most fetal PFASs (r=-0.229 to -0.165 for T3; r=-0.293 to -0.169 for FT3, all P<0.05). Our results suggest prenatal exposure of fetus to PFASs and potential associations between PFASs and thyroid hormone homeostasis in humans.


PubMed | National Institute of Nutrition and Health
Type: | Journal: Clinica chimica acta; international journal of clinical chemistry | Year: 2015

We compared the utility of two 25-OH-D immunoassays to a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for assessing human serum samples from the Chinese population.In total, 451 Chinese serum samples were tested using the IDS 25-Hydroxy Vitamin D EIA kits and the LC-MS/MS 25-OH-D method. Of these, 239 samples were also analysed using DiaSorin 25-Hydroxyvitamin D RIA kits.The regression coefficients (r) between LC-MS/MS and immunoassays were 0.8430 (95% CI: 0.8140-0.8678) for IDS-EIA and 0.8187 (95% CI: 0.7720-0.8566) for DiaSorin-RIA. Using the Passing-Bablok analysis, IDS-EIA and DiaSorin-RIA yielded results equivalent to those from LC-MS/MS. However, IDS-EIA showed negative bias and DiaSorin-RIA showed positive bias when compared to LC-MS/MS, as indicated by the Bland-Altman plots. By the kappa test, both IDS-EIA and DiaSorin-RIA were in acceptable agreement with LC-MS/MS in the assessment of vitamin D deficiency and insufficiency.Although some systematic bias was found, the DiaSorin-RIA and IDS-EIA kits met the minimum performance goal for 25-OH-D measurement and can be recommended for routine use in the Chinese population. However, further studies are needed to assess 25-OH-D measurement immunoassays with lower bias and that are more suitable for the Chinese population.


PubMed | National Institute of Nutrition and Health, Ministry of Health and China National Center for Food Safety Risk Assessment and China National Institute for Nutrition and Food Safety
Type: | Journal: Chemosphere | Year: 2016

Perfluoroalkyl substances (PFASs), a group of environmental pollutants, persistently exist in the environment. To investigate the associations between PFASs levels in cord serum and birth weight, birth length and ponderal index, we measured PFASs in cord serum samples from 170 infants from Feb. 2012 to Jun. 2012 in Beijing, China. The mean concentrations in cord serum samples for perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA) and perfluoroundecanoic acid (PFUnA) were 1.285ng/mL, 1.228ng/mL, 0.230ng/mL, 0.224ng/mL, 0.100ng/mL and 0.085ng/mL, respectively. First-born children had slightly higher exposure levels of PFHxS (p<0.001) and PFOA (p=0.03) than second-born or third-born children. The spearman correlation coefficients with gestation time were individually 0.160 (p=0.038) for PFHxS and 0.202 (p=0.008) for PFOA. Both univariate and multivariate linear regression analysis showed that the exposure levels of PFASs had no statistically significant associations with birth weight, birth length or ponderal index in the present population. For male infants, we observed that PFHxS positively correlated with birth length, but the levels of PFUnA were negatively associated with birth length.


PubMed | National Institute of Nutrition and Health
Type: | Journal: Public health nutrition | Year: 2015

To evaluate vitamin D deficiency prevalence and risk factors among pregnant Chinese women.A descriptive cross-sectional analysis.China National Nutrition and Health Survey (CNNHS) 2010-2013.A total of 1985 healthy pregnant women participated. Possible predictors of vitamin D deficiency were evaluated via multiple logistic regression analyses.The median serum 25-hydroxyvitamin D level was 155 (interquartile range 119-200, range 30-515) ng/ml, with 749 (95 % CI 730, 767) % of participants being vitamin D deficient (25-hydroxyvitamin D <20 ng/ml). According to the multivariate logistic regression analyses, vitamin D deficiency was positively correlated with Hui ethnicity (P=0016), lack of vitamin D supplement use (P=0021) and low ambient UVB level (P<0001). In the autumn months, vitamin D deficiency was related to Hui ethnicity (P=0012) and low ambient UVB level (P<0001). In the winter months, vitamin D deficiency was correlated with younger age (P=0050), later gestational age (P=0035), higher pre-pregnancy BMI (P=0019), low ambient UVB level (P<0001) and lack of vitamin D supplement use (P=0007).Vitamin D deficiency is prevalent among pregnant Chinese women. Residing in areas with low ambient UVB levels increases the risk of vitamin D deficiency, especially for women experiencing advanced stages of gestation, for younger pregnant women and for women of Hui ethnicity; therefore, vitamin D supplementation and sensible sun exposure should be encouraged, especially in the winter months. Further studies must determine optimal vitamin D intake and sun exposure levels for maintaining sufficient vitamin D levels in pregnant Chinese women.


PubMed | National Institute of Nutrition and Health
Type: Journal Article | Journal: Asia Pacific journal of clinical nutrition | Year: 2015

BACKGROUND AND OBJECTIVESMore than 30 years of socioeconomic development in China has improved living conditions which contributed to a steep decline in malnutrition prevalence of children under 5 years. To elucidate the role of socioeconomic development in improving nutritional status and to identify appropriate policy priorities for intervention in nutrition improvement for younger children.We collected data on socioeconomic development, education, cultural and recreational services, food consumption, average family size and malnutrition prevalence from national surveys.From 1990 to 2010, Gross Domestic Product (GDP) per capita increased from 1644 Chinese Yuan (CNY) to 30,015 CNY; average disposable income and food expenditure per capita significantly increased in urban and rural areas; per capita consumption for education increased from 112 CNY to 1628 CNY and from 15.3 CNY to 367 CNY for other cultural services; illiteracy rate decreased from 15.9% to 4.1%; average family size from 3.97 to 3.10; and prevalence of stunting and underweight decreased from 33.1% to 9.9% and 13.7% to 3.6%, respectively. However, anaemia prevalence did not obviously decline between 1992 and 2000. After adjusting confounding effects of variables, negative relationships were observed between GDP per capita, average family size and stunting or underweight prevalence. However, no association was observed between illiteracy rate and prevalence of stunting and underweight, and there was no correlation between GDP per capita, illiteracy rate, average family size and anaemia prevalence.Our results indicated that economic development cannot solve all nutritional problems and comprehensive national developmental strategies should be considered to combat malnutrition.

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