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Khatuja R.,University of Delhi | Jain G.,University of Delhi | Mehta S.,University of Delhi | Arora N.,University of Delhi | And 2 more authors.
Minimally Invasive Surgery | Year: 2014

Aim. To find out the changing trends in indications for use of laparoscopy for diagnostic or operative procedures in gynaecology. Methods. This was a clinical audit of 417 women who underwent laparoscopic procedures over a period of 8 years from January 2005 to December 2012 in the Department of Obstetrics and Gynaecology at a tertiary care centre in Delhi. Results. A total of 417 diagnostic and operative laparoscopic procedures were performed during the period from January 2005 to December 2012. Out of 417 women, 13 women were excluded from the study due to inadequate data. 208 (51.4%) women had only diagnostic laparoscopy whereas 196 (48.6%) patients had operative laparoscopy after the initial diagnostic procedure. Change in trend of diagnostic versus operative procedures was observed from 2005 to 2012. There was increase in operative procedures from 10 (37.03%) women in 2005 as compared to 51 (73.91%) in 2012.The main indication for laparoscopy was infertility throughout the study period (61.38%), followed by chronic pelvic pain (CPP) (11.38%) and abnormal uterine bleeding (AUB) (9.4%). Conclusion. Over the years, there has been a rise in the rate of operative laparoscopy.Though the indications for laparoscopy have remained almost similar during the years, laparoscopy for diagnosis and treatment of CPP and AUB has now increased. Copyright © 2014 Ritu Khatuja et al. Source


Kumar G.,National Bureau of Fish Genetic Resources | Sharma P.,National JALMA Institute for Leprosy and Other Mycobacterial Diseases ICMR | Rathore G.,National Bureau of Fish Genetic Resources | Bisht D.,National JALMA Institute for Leprosy and Other Mycobacterial Diseases ICMR | Sengupta U.,National Institute of Medical Statistics ICMR
Journal of Applied Microbiology | Year: 2010

Aims: The purpose of this study was to identify outer membrane proteins (OMPs) of Edwardsiella tarda. Methods and Results: The OMPs from a virulent strain of E. tarda (ET-7) was extracted using lauroyl sarcosine method. The OMPs were analysed by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), and protein spots were identified using matrix assisted laser desorption/ionization-time-of-flight mass spectrometry. A total of 21 proteins were identified from 24 protein spots observed on the 2D-PAGE gel. These proteins were identified as GroEL, antigenic proteins, ABC transporters, elongation factors, OmpA, PTSINtr with GAF domain, catalase C, glycolytic enzymes, DnaJ, transcriptional regulator, proteins mraZ and ccdA. Subcellular localizations, β-barrel OMPs and lipoproteins of identified proteins were predicted using PSORTb, PRED-TMBB and LipoP1.0 programme. Conclusions: Identification, localization and possible functions of OMPs of E. tarda were studied. Significance and Impact of the Study: These proteins could be used for development of novel drug targets, diagnostics or vaccine against edwardsiellosis. © 2009 The Society for Applied Microbiology. Source


Khatuja R.,BSA | Jain G.,89 North Speciality Clinic | Radhakrishnan G.,UCMS and Guru Teg Bahadur Hospital | Radhika A.G.,UCMS and Guru Teg Bahadur Hospital | And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2015

Introduction: Obstetrical haemorrhage is the direct cause of maternal mortality, which can be prevented by timely recognition followed by quick and adequate treatment. Aim: To evaluate maternal and perinatal outcome of life threatening obstetric complications requiring multiple transfusions. Materials and Methods: It is an observational study conducted on 112 antenatal and postnatal women admitted in a tertiary level hospital, requiring blood and blood products transfusion of >1.5 liters in 24 hours, over a period of 15 months (Aug 2011 to Oct 2012). The demographic and obstetrical profile, amount transfused, mode of delivery, duration of hospital stay, maternal and neonatal morbidity and mortality was evaluated. Statistical Analysis: Statistical analysis of the data was performed using chi-squared test. Results: There were 95 women who presented in antepartum period and 17 in the postpartum. Multigravidas comprised of 70 women, 81 had unsupervised pregnancies and 33 women presented in shock. At admission, 76 peripartum women had severe anaemia and 62 had coagulopathy. Obstetrical hysterectomy was done for 33 women and total 17 women expired. Haemorrhage was the most common indication for transfusion. The mean blood transfusion and volume replacement in 24 hours was 4.2 units & 2.25 liters respectively. The mean hospital stay was 10-15 days. Intra-uterine death at the time of admission was present in 40 women and 72 had live births. After birth, 21 babies required neonatal intensive care, of which 6 expired. Conclusion: Antenatal care is important to prevent complications though pregnancy is always unpredictable. Patients’ condition at admission is single most important factor often influencing the maternal and perinatal outcome. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved. Source


Jain G.,89 North Speciality Clinic | Khatuja R.,Balak Ram Hospital | Juneja A.,National Institute of Medical Statistics ICMR | Mehta S.,Babu Jagjivan Ram Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Introduction: The role of diagnostic and therapeutic hystero-laparoscopy in women with infertility is well established. It is helpful not only in the identification of the cause but also in the management of the same at that time.Methodology: In this study, the aim was to analyse the results of 203 women on whom laparoscopy for the evaluation of infertility was done. This study was carried out at a tertiary level hospital from 2005 to 2012. The study group included 121 women with primary infertility and 82 women with secondary infertility. Women with incomplete medical records and isolated male factor infertility were excluded from the study.Results: It was observed that tubal disease was the responsible factor in 62.8% women with primary infertility and 54.8% women with secondary infertility followed by pelvic adhesions in 33% and 31.5%, ovarian factor in 14% and 8.5%, pelvic endometriosis in 9.9% and 6.1% women respectively. Thus tubal factor infertility is still a major cause of infertility in developing countries and its management at an early stage is important to prevent an irreversible damage. At the same time, it also directs which couples would be benefited from assisted reproductive technologies (ART). © 2014, Journal of Clinical and Diagnostic Research. All rights reserved. Source


Pandey A.,National Institute of Medical Statistics ICMR | Mishra R.M.,Population Council | Sahu D.,National Institute of Medical Statistics ICMR | Benara S.K.,National Institute of Medical Statistics ICMR | And 4 more authors.
Indian Journal of Medical Research, Supplement | Year: 2012

Background & objectives: The long distance truck drivers play an important role in the spread of HIV and sexually transmitted infections (STIs). The present study was carried out to examine association of marital status with heterosexual risk behaviour, condom use and prevalence of STI and HIV among long-distance male truck drivers in India. Methods: Using the time location cluster sampling approach, major transshipment locations covering the bulk of India's transport volume were surveyed in 2007. A total of 2,066 long-distance male truck drivers were surveyed and, after consent, interviewed about their socio-demographic characteristics, sexual behaviours, condom use practices, and tested for HIV, reactive syphilis serology, Neiserria gonorrhoeae and Chlamydia trachomatis. The key variable of this study marital status was divided in two categories: married and unmarried. Data were analyzed using multiple logistic regression methods with following four binary outcome variables (i) whether had sex with any non-regular partners in past 12 months; (ii) whether used condom consistently in past 12 months; (iii) whether tested positive for any STI; and (iv) whether tested positive for HIV. Results: Compared to married truck drivers, unmarried were significantly more likely to have sex with non-regular female partners (30.2 versus 66.9%, OR: 5.7, 95% CI 3.6-8.9), less likely to use condom consistently with non-regular female partners (50.1 versus 38.8%, OR: 0.7, 95% CI: 0.4-1.1) and more likely to have HIV (3.7 versus 3.4%, OR: 2.7, 95% CI: 1.1-6.5). Interpretation & conclusions: Unmarried truck drivers have a higher HIV risk behaviour and consequently they were more likely to have HIV than married drivers. Despite of high-risk behaviours, risk-perception remains low among both married and unmarried truck drivers. This belief coupled with inconsistent condom use put currently married long distance truck drivers as well as their wives at risk of getting infected from STI and HIV. Source

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