National Institute of Medical science

Jaipur, India

National Institute of Medical science

Jaipur, India
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Pahwa P.,Bhagwan Parshuram Institute of Technology | Pahwa P.,National Institute of Medical science | Papreja M.,National Institute of Medical science | Papreja M.,GVM Institute of Technology and Management
Acta Poloniae Pharmaceutica - Drug Research | Year: 2012

Self-organizing molecular field analysis (SOMFA), a simple three-dimensional quantitative structure activity relationship (3D-QSAR) based cheminformatics method was used in present case to study the correlation between the molecular properties and the PTP 1B inhibitory activities of a series of 1,2-naphthoquinone that acts as selective PTP 1B inhibitors. The statistical results, cross-validated r 2 cv and non cross-validated r 2, F-test value showed a satisfied predictive ability (r 2 pred). The spatial arrangement of the shape and electrostatic potential could be used as a guide for further development of selective and more potent PTP 1B inhibitors.

Salna K.P.,National institute of Medical science | Sreejith K.,Loyola College | Uthiralingam M.,Loyola College | Prince M.A.,Sir Theagaraya College | And 2 more authors.
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Among ancient civilisations, India has been known to be rich repository of medicinal plants. The traditional medicine involves the use of different plant extracts or the bioactive constituents. This type of study provides the health application at affordable cost. The study such as ethno medicine keenly represents one of the best avenues in searching new economic plants for medicine. A comparative study of phytochemicals was made on leaf extracts of two herbal plants- Andrographis paniculata and Murraya koenigii. The leaf extracts were prepared with six different selected solvents for each plant to adjudge the major active principles in the solvent that have value in rational drug design. The qualitative analysis of phytochemicals encompasses steroids, alkaloids, flavonoids, triterpenoids, tannins, saponins, quinone, coumarin, protein, sugar and gum. The presence of these various phytochemicals shows the importance of A.paniculata and M.koenigii which could be used to cure various ailments.

Aher V.D.,JKK Nataraja Dental College and Hospital | Kumar A.,National Institute of Medical science | Wahi,JKK Nataraja Dental College and Hospital
Journal of Pharmaceutical Sciences and Research | Year: 2010

Most of the synthetic chemotherapeutic agents are immunosuppressants and exerts variety of side effects. The herbal based immunomodulators are employed as supportive or adjuvant therapy to overcome the undesired effects of chemotherapeutics agents. Herbal drugs will be significantly more effective and highly efficacious supplement to use as a general adaptogen and immune strengthener in healthy people and as a very useful, safe and effective nutrient support tonic for those challenged by disease. The present work described that Terminalia chebula alcoholic extract shows immunomodulator activity. The various parameters determined were differential leukocyte count (DLC), phagocytic activity and zinc sulphate turbidity test. Oral administration of T. chebula alcoholic extract (100 mg/kg, p.o.) was found to increase the neutrophils and lymphocytes as compared to vehicle and cyclophosphamide treated groups. T. chebula alcoholic extract showed linear time dependent significant phagocytic activity as compared to SRBC sensitized and cyclophosphamide treated group. In zinc sulphate turbidity test T. chebula treated rats serum showed more turbidity (cloudy) which indicate the increase in the immunoglobulin level as compared to vehicle, SRBC sensitized and cyclophosphamide treated group. Finally it can be concluded that Terminalia chebula ripe fruits show potent immunomodulatory action.

Kumar V.,Sn Medical College | Modi P.K.,National Institute of Medical science | Saxena K.K.,LLRM Medical College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Background and Objectives- Tinospora cordifolia (Willd.) Miers ex Hook. f. & Thoms. (T. cordifolia) has been shown to be hepatoprotective by Ayurvedic physicians but has not been scientifically evaluated so far. So, the present study was undertaken to explore the hepatoprotective activity of T. cordifolia against experimentally induced hepatotoxicity in albino rats. Aim of The Study-To explore the hepatoprotective activity of T. cordifolia. Materials and Methods- Albino Wistar rats weighing 150-200g of either sex were divided into six groups of six animals each. Group I was given normal saline (PO), group II carbon tetrachloride(CCl4) (IP), group III Liv.52 syrup for twenty days followed by carbon tetrachloride, group IV, V & VI received aqueous extract of T. cordifolia (1ml/100g twice daily) orally for 10, 20 & 30 days respectively followed by CCl4 administration. Blood was collected from anaesthetized animals & liver was dissected out. Alanine transaminase (ALT), Alkaline phosphatase (ALP) & Total bilirubin were estimated and liver was subjected to histopatological examination. Results-ALT, ALP & Total bilirubin levels were significantly increased in CCl4 treated group while T. cordifolia displayed significant reduction in rise in these parameters in group IV, V & VI. This hepatoprotection was also reflected in histologal changes. Interpretation and Conclusion-It can be concluded from the present study that T. cordifolia extract is a potent hepatoprotective agent. It is assumed that this hepatoprotective effect of T. cordifolia may be due to several reasons such as antioxidant and/or free radical scavenger property and ability to induce hepatic regeneration.

Kakodkar G.,National Institute of Medical science | Lavania A.,National Institute of Medical science | de Noronha de Ataide I.,Goa Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2013

Introduction: Tooth whitening products enjoy substantial popularity. However, tooth hypersensitivity is invariably an undesirable consequence. Desensitizing toothpastes may be used for alleviating the symptoms. Novamin, as an active ingredient in many dentifrices, has been shown to deliver significant therapeutic desensitising benefits. Aim: To study the effect of Novamin desensitising toothpaste mixed with 15% carbamide peroxide on tooth bleaching and tubule occlusion. Material and Methods: This study was carried out in vitro, on extracted premolars which were bleached, using the above mentioned mixture and shade change was evaluated. They were then sectioned to be observed under a scanning Electron Microscope. The number of completely and partially blocked tubules as well as open tubules were counted for each specimen. Statistical analysis for shade change was done by using paired t-test. Mean and Standard deviation were calculated for the tubule counts and they were analyzed statistically. Conclusion: The results of this study indicated that the addition of Novamin to 15% Carbamide peroxide occluded the dentinal tubules and that it did not affect the bleaching procedure. They also emphasized its clinical relevance in a dual advantage of desensitizing and bleaching with a single paste system.

PubMed | National Institute of Medical science and MGM Medical College
Type: Journal Article | Journal: Bulletin of emergency and trauma | Year: 2016

Carpal injuries are uncommon and are mainly seen in the younger age group. The incidence is unclear as many of the cases go undiagnosed. A 22-year-old male patient coming to the hospital after road traffic accidentwith head, face and left wrist injury. After immediate primary management the patient was taken up for a definitive procedure 4 days after the injury. Scaphoid fracture was fixed with the help of Herberts screw via the dorsal approach. The base of the first metacarpal was fixed with the help of JESS fixator and the distal end radius was fixed with the help of K-wires. The scapholunate and lunato triquetral ligaments were repaired. The whole construct was stabilized with the help of an external fixator. Postoperative period was uneventful. The external fixator was removed after 4 weeks and patient had a good functional outcome with the patient related wrist evaluation score coming out to be 11 at the end of the third month. This uncommon case of Transradial, Trans scaphoid, transcapitate, and perilunate dislocation was managed successfully with no postoperative complications and a good functional outcome.

PubMed | National Institute of Medical Science and Chulalongkorn University
Type: Journal Article | Journal: Medical mycology | Year: 2016

The yeasts Malassezia (M.) pachydermatis and Candida (C.) parapsilosis are often co-isolated in case of canine seborrhea dermatitis (SD) and also are emerging as opportunistic pathogens of immunocompromised human beings. Increased information about how their relationship results in biofilm production and an antifungal response would be useful to inform treatment and control. This study was designed to investigate biofilm production derived from co-culture of M. pachydermatis and C. parapsilosis from dog skin and to determine their in vitro antifungal susceptibility. We demonstrated that regardless of yeast strain or origin all single and dual cultures produced biofilms within 24 hours, and the greatest amount was present after 72 hours. Biofilm production from mixed cultures was greater than for single strains (P < .05). All sessile forms of the single and dual cultures were resistant to the tested antifungals itraconazole and ketoconazole, whereas planktonic forms were susceptible. The study suggests that dual cultures produce stronger biofilms that are likely to enhance persistence in skin lesions in dogs and result in greater resistance to antifungal treatment.

Hudson R.,National Autonomous University of Mexico | Maqueda B.,Metropolitan Autonomous University | Velazquez Moctezuma J.,Metropolitan Autonomous University | Morales Miranda A.,National Institute of Medical science | Rodel H.G.,University of Bayreuth
Physiology and Behavior | Year: 2011

Many aspects of an animal's early development contribute to the emergence of individual differences in physiology. Here we asked whether litter size, birth mass, suckling success and postnatal growth were predictors of individual differences in testosterone (T) and corticosterone (CORT) levels in neonatal domestic rabbits. Serum concentrations of both hormones, which we measured on postnatal day 8, were significantly and positively correlated with pup growth and milk intake. Litter size and birth mass were not significantly correlated with levels of T and CORT, although both parameters were indirectly associated with the levels of these hormones via their effects on milk intake and pup growth. Our results highlight the importance of naturally occurring features of the postnatal environment in shaping individual differences in T and CORT levels during early life. © 2011 Elsevier Inc.

PubMed | National Institute of Medical science, University of Michigan, University of Otago and Harvard University
Type: Journal Article | Journal: Nutrients | Year: 2016

Many factors put Mongolians at risk of vitamin D deficiency. Despite low levels observed in Mongolian children and pregnant women, there are few data published on the vitamin D status of non-pregnant adults. Between summer 2011 and winter 2013, paired summer and winter blood samples were collected from 320 healthy men and women (20-58 years) living in eight Mongolian provinces. Mean serum 25(OH)D concentrations were 22.5 ng/mL (95% CI: 14.5, 32.5) in summer and 7.7 ng/mL (95% CI: 4.6, 10.8) in winter, with a distribution (<10/10-20/20-30/30 ng/mL) of 3.1%/39.3%/39.6%/17.9% in summer and 80.1%/19.5%/0.3%/0.0% in winter. Residents of the capital, Ulaanbaatar, had lower levels in both seasons than any other region, whereas residents of the Gobi desert had the highest. In summer, indoor workers had significantly lower levels than outdoor workers (-2.3 ng/mL; 95% CI: -4.1, -5.7) while levels in males exceeded those in females (4.0 ng/mL; 95% CI: 2.3, 5.7). Effects of region, occupation, and sex were also significant in multivariable regression. In conclusion, Mongolian adults had extremely low serum 25(OH)D, particularly in winter, when 80.1% had concentrations below 10 ng/mL. These results indicate a need for effective vitamin D interventions for the Mongolian adult population, particularly among women and residents of Ulaanbaatar.

PubMed | National Institute of Medical science
Type: Journal Article | Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology | Year: 2016

17148 Background: Gemcitabine is established treatment modality for NSCLC. However its introduction on day 8 is sometimes delayed because of low counts or poor patient acceptance because of effects of d1 dose.We have used gemcitabine 10000 mg/mThe patients tolerated the chemotherapy (4 to 6 cycles) satisfactorily and none of the patient required delaying of the d10 therapy. Complete regression was seen in 2 patients,partial regression in 22 patients.the median survival was 10.2 months.The d1-10 schedule of gemcitabine based chemotherapry is safe,effective and better tolerated then the d1-d8 schedule. No significant financial relationships to disclose.

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