Entity

Time filter

Source Type


Hudson R.,National Autonomous University of Mexico | Maqueda B.,Metropolitan Autonomous University | Velazquez Moctezuma J.,Metropolitan Autonomous University | Morales Miranda A.,National Institute of Medical science | Rodel H.G.,University of Bayreuth
Physiology and Behavior | Year: 2011

Many aspects of an animal's early development contribute to the emergence of individual differences in physiology. Here we asked whether litter size, birth mass, suckling success and postnatal growth were predictors of individual differences in testosterone (T) and corticosterone (CORT) levels in neonatal domestic rabbits. Serum concentrations of both hormones, which we measured on postnatal day 8, were significantly and positively correlated with pup growth and milk intake. Litter size and birth mass were not significantly correlated with levels of T and CORT, although both parameters were indirectly associated with the levels of these hormones via their effects on milk intake and pup growth. Our results highlight the importance of naturally occurring features of the postnatal environment in shaping individual differences in T and CORT levels during early life. © 2011 Elsevier Inc. Source


Bansal N.,Government Medical College and Hospital | Chaudhary U.,Health Science University | Gupta V.,National Institute of Medical science
Kuwait Medical Journal | Year: 2011

Objectives: Clindamycin is a preferred therapeutic option in erythromycin resistant Staphylococcus aureus skin and soft tissue infections. However, a major concern regarding its use for staphylococcal infections is the possible presence of inducible resistance to clindamycin. The present study was aimed to determine the incidence of constitutive and inducible clindamycin resistance in S.aureus isolates in our hospital. Design: Retrospective study Setting: Pt. BDS University of Health Sciences, Rohtak, Haryana, India Subjects: A total of 250 consecutive, non-duplicate S.aureus strains were isolated from various clinical specimens, both from inpatients and outpatients. Intervensions: Antibiotic susceptibility tests were performed using Kirby-Bauer disc diffusion method. Methicillin resistance was detected by oxacillin disc on Mueller-Hinton Agar (MHA) plate supplemented with 2% NaCl. D-test was performed on all erythromycin-resistant and clindamycin-sensitive isolates to detect inducible clindamycin resistance. Main Outcome Measures: Observed and counted were methicillin resistance in S.aureus, constitutive and inducible resistance of the isolates to clindamycin, origin of the MLSBi isolates that is "community" or "hospital" and resistance of MLSBi isolates to other drugs. Results: Among 250 S.aureus strains, 112 (44.8%) were found to be Methicillin-resistant Staphylococcus aureus (MRSA) and 20% had MLSBi phenotype. MRSA isolates showed higher inducible as well as constitutive resistance (p < 0.0001) to clindamycin as compared to methicillin-sensitive S.aureus (MSSA). All S.aureus isolates having MLSBi phenotype were sensitive to vancomycin and linezolid. Conclusions: The study strongly recommends the routine testing of in vitro inducible clindamycin resistance in S.aureus isolates as it will help in guiding therapy. Source


Kumar V.,SN Medical College | Modi P.K.,National Institute of Medical science | Saxena K.K.,LLRM Medical College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Background and Objectives- Tinospora cordifolia (Willd.) Miers ex Hook. f. & Thoms. (T. cordifolia) has been shown to be hepatoprotective by Ayurvedic physicians but has not been scientifically evaluated so far. So, the present study was undertaken to explore the hepatoprotective activity of T. cordifolia against experimentally induced hepatotoxicity in albino rats. Aim of The Study-To explore the hepatoprotective activity of T. cordifolia. Materials and Methods- Albino Wistar rats weighing 150-200g of either sex were divided into six groups of six animals each. Group I was given normal saline (PO), group II carbon tetrachloride(CCl4) (IP), group III Liv.52 syrup for twenty days followed by carbon tetrachloride, group IV, V & VI received aqueous extract of T. cordifolia (1ml/100g twice daily) orally for 10, 20 & 30 days respectively followed by CCl4 administration. Blood was collected from anaesthetized animals & liver was dissected out. Alanine transaminase (ALT), Alkaline phosphatase (ALP) & Total bilirubin were estimated and liver was subjected to histopatological examination. Results-ALT, ALP & Total bilirubin levels were significantly increased in CCl4 treated group while T. cordifolia displayed significant reduction in rise in these parameters in group IV, V & VI. This hepatoprotection was also reflected in histologal changes. Interpretation and Conclusion-It can be concluded from the present study that T. cordifolia extract is a potent hepatoprotective agent. It is assumed that this hepatoprotective effect of T. cordifolia may be due to several reasons such as antioxidant and/or free radical scavenger property and ability to induce hepatic regeneration. Source


Bansal N.,Government Medical College Hospital | Chaudhary U.,Health Science University | Gupta V.,National Institute of Medical science
Annals of Tropical Medicine and Public Health | Year: 2012

Background: Coagulase negative staphylococci (CoNS) are an important group of multi-drug resistant nosocomial pathogens. Clindamycin resistance in staphylococci can be either constitutive or inducible. Clindamycin has been used successfully to treat pneumonia, soft-tissue and musculoskeletal infections due to methicillin-resistant CoNS (MRCoNS) in adults and children, but this matter is complicated by the possibility of inducible macrolide-lincosamide streptogramin B resistance (MLSBi). Aims: The present study was aimed to determine the incidence of inducible clindamycin resistance in CoNS isolates in our hospital using D-test, relationship between MRCoNS and MLSBi isolates, association of MLSBi isolates with community or nosocomial setting and treatment options for these isolates. Materials and Methods: A total of 250 consecutive, non-duplicate strains of CoNS were isolated from various clinical specimens, both from indoor and outdoor patients. After determining methicillin resistance, D-test was performed on all erythromycin-resistant and clindamycin-sensitive isolates to detect inducible clindamycin resistance. Results: Among 250 CoNS isolates, 89 (35.6%) were found to be MRCoNS and 20% had MLSBi phenotype. MRCoNS showed higher inducible as well as constitutive resistance (p<0.0001) to clindamycin as compared to methicillin-sensitive CoNS (MSCoNS). All isolates having MLSBi phenotype were sensitive to vancomycin and linezolid. Conclusions: Clindamycin is a useful drug in the treatment of staphylococcal infections. Hence, routine testing of staphylococcal isolates for inducible clindamycin resistance is strongly recommended. Source


Singh S.M.,PGIMER | Narang T.,Venereology and Leprology | Dogra S.,Venereology and Leprology | Verma A.K.,Vardhman Institute of Medical science | And 2 more authors.
Indian Journal of Dermatology, Venereology and Leprology | Year: 2015

Background: Psoriasis and depressive disorders commonly occur together. Depressive disorders have an impact on the quality of life and the outcome of psoriasis. Aims: The aim of this study was to test the feasibility of using a modification of the Hindi translation of the Patient Health Questionnaire-9 (PHQ-9) as a verbal, clinician administered, short screening questionnaire for detecting depressive disorders. Materials and Methods: One hundred and four out-patients with psoriasis were recruited in the study. In the first stage of the study, socio-demographic data, Psoriasis Area Severity Index (PASI) score, and Dermatological Quality of Life (DLQI) score were recorded. The modified questionnaire was administered by the dermatologist. In the second stage, psychiatric diagnoses were confirmed using the Mini International Neuropsychiatric Interview. Results: The prevalence of depressive disorders was 39.4%. Receiver operating curve (ROC) analysis showed that the questionnaire had a good discriminant ability in detecting depressive disorders (area under curve: 0.81, SE = 0.04, 95% confidence interval = 0.72-0.89). Limitations: The sample size is small and more studies are needed with the screening questions in different languages to validate the findings of the study. Conclusion: The questionnaire can be a useful screening instrument for detecting depressive disorders in patients with psoriasis. Source

Discover hidden collaborations