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Satyan R.S.,M S Swaminathan Research Foundation | Sakthivadivel M.,National Institute of Malaria Research NIMR ICMR | Shankar S.,SASTRA University | Dinesh M.G.,Thanthai Hans Roever College
Natural Product Research | Year: 2012

Excoecaria agallocha Linn. The blinding mangrove tree of historical significance, is well known for its curative properties. In this investigation, crude hexane extract from the dried roots of E. agallocha inhibited 50% of the growth of third instar larvae of Culex quinquefasciatus Say. within 24h (LC 50: 315ppm). SiO2 (60-120) column chromatography purification of the extract yielded four fractions, of which fractions 3 (LC50: 61.2ppm) and 4 (LC50: 74.5ppm) exhibited 100% larvicidal activity within 18-24h. Bioactive fraction 3 contained sub-fractions R1 and R2. R1 was characterised by 1H-NMR, 13C-NMR and FAB mass spectrometry techniques as the acyclic hydrocarbon n-triacontane (C 30H62). © 2012 Taylor & Francis Group, LLC.

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