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Marin J.J.G.,University of Salamanca | Marin J.J.G.,Carlos III National Institute of Health | Bujanda L.,Carlos III National Institute of Health | Bujanda L.,University of the Basque Country | And 3 more authors.
Current Opinion in Gastroenterology | Year: 2014

Purpose of Review To highlight the increasing evidence supporting the concept that microRNAs (miRNAs) are involved in the cause and pathogenesis of cholestatic liver disorders. Recent Findings miRNAs play a key role in maintaining bile acid homeostasis and modulating pathological processes associated to liver cholestasis, such as proliferation, apoptosis, fibrosis and cancer. Changes in the expression level of specific miRNAs have been reported in serum, peripheral blood mononuclear cells or liver tissue from patients suffering from chronic cholestatic liver diseases, such as primary biliary cirrhosis. Summary: Although our understanding regarding the role of miRNAs in the development and progression of cholestatic liver diseases is still limited, in the present review, we have revised and discussed the recent information that has emerged on the role of miRNAs in the secretory function of the liver under physiological and pathological conditions. This has led to suggest their potential usefulness as biomarkers for the diagnosis and monitoring of cholestatic liver diseases, as well as tools for the development of novel therapeutic strategies.


PubMed | Autonomous University of Madrid and Carlos III National Institute of Health
Type: | Journal: Environmental research | Year: 2016

Spain has one of the highest proportions of dementia in the world among the population aged 60 years or over. Recent studies link various environmental factors to neurocognitive-type diseases. This study sought to analyse whether urban risk factors such as traffic noise, pollutants and heat waves might have a short-term impact on exacerbation of symptoms of dementia, leading to emergency hospital admission.We conducted a longitudinal ecological time-series study, with the dependent variable being the number of daily dementia-related emergency (DDE) hospital admissions to Madrid municipal hospitals (ICD-10 codes 290.0-290.2, 290.4-290.9, 294.1-294) from 01 to 01-2001 to 31-12-2009, as obtained from the Hospital Morbidity Survey (National Statistics Institute). The measures used were as follows: for noise pollution, Leqd, equivalent diurnal noise level (from 8 to 22h), and Leqn, equivalent nocturnal noise level (from 22 to 8h) in dB(A); for chemical pollution, mean daily NO2, PM2.5, PM1 as provided by the Madrid Municipal Air Quality Monitoring Grid; and lastly, maximum daily temperature (C), as supplied by the State Meteorological Agency. Scatterplot diagrams were plotted to assess the type of functional relationship existing between the main variable of analysis and the environmental variables. The lags of the environmental variables were calculated to analyse the timing of the effect. Poisson regression models were fitted, controlling for trends and seasonalities, to quantify relative risk (RR).During the study period, there were 1175 DDE hospital admissions. These admissions displayed a linear functional relationship without a threshold in the case of Leqd. The RR of DDE admissions was 1.15 (1.11-1.20) for an increase of 1dB in Leqd, with impact at lag 0. In the case of maximum daily temperature, there was a threshold temperature of 34C, with an increase of 1C over this threshold posing an RR of 1.19 (1.09-1.30) at lag 1. The only pollutant to show an association with DDE hospital admissions was O3 at lag 5, with an RR of 1.09 (1.04-1.15) for an increase of 10g/m

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