National Institute of Forensic Medicine

Amman, Jordan

National Institute of Forensic Medicine

Amman, Jordan
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Duc L.V.,Vietnam National University, Hanoi | Thanh T.B.,Vietnam National University, Hanoi | Huu T.N.,Vietnam National University, Hanoi | Thanh H.N.,Vietnam National University, Hanoi | And 2 more authors.
International Journal of Pharmacognosy and Phytochemical Research | Year: 2015

The roots of Aconitum Carmichaeli Debx. is recognized as a medicinal plant by its anti-inflammatory and analgesic effects. Our phytochemical investigation of the roots led to the isolation of three alkaloids including delcosine (1), fuziline (2), and karacoline (3). Their structures were identified on the basis of NMR, MS, IR spectroscopic analysis and comparison with the published NMR data. Compound 1 was isolated for the first time from this plant. © 2015, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.

Toro K.,Semmelweis University | Vali M.,University of Tartu | Vali M.,Estonian Forensic Science Institute | Lepik D.,University of Tartu | And 6 more authors.
Journal of Forensic and Legal Medicine | Year: 2013

Evaluation of the pathomorphological characteristics of cases involving natural and sudden cardiovascular death is essential for the determination of the cause of death. The main purpose of this study is to investigate sudden unexpected cardiovascular death and to study how different geographical climatic influences may affect cardiac mortality in three capitals: Budapest, Vilnius and Tallinn. There were 8482 (5753 male, 2729 female) cardiovascular deaths between 2005 and 2009. The highest rate was observed in the age group between 71 and 80 years (35.17%) and 51-60 years (24.45%). The highest number of cardiovascular deaths occur in January (805/9.49%) and December (770/9.07%). Seasonal distribution was observed, with winter prevalence in Tallinn (279/3.20%) and spring prevalence in Vilnius (760/8.90%). Though in Vilnius and Budapest a great number of deaths occurred in winter and spring, any correlation with other factors (e.g. age, gender, BAC) was not statistically significant. Based on our results we can conclude that environmental-geographical parameters may affect natural cardiovascular death. Examination of pathological patterns and predisposing environmental parameters may help to improve prevention strategies. © 2013 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Duc L.V.,Vietnam National University, Hanoi | Thanh T.B.,Vietnam National University, Hanoi | Thanh H.N.,Vietnam National University, Hanoi | Tien V.N.,National Institute of Forensic Medicine
Journal of Applied Pharmaceutical Science | Year: 2016

Goniothalamus chinensis Merr. & Chun is a medicinal plant which has cytotoxicity, antitumor, antifungal, antimalaria and antituberculosis and antioxidant activity. The styryl-lactone, alkaloid and acetogenin are the main group compounds in species of Goniothalamus. In this study, we aimed to investigate phytochemical and cytotoxic effect of compounds from bark of Goniothalamus chinensis Merr. & Chun. The bark of Goniothalamus chinensis Merr. & Chun grown in Vietnam was extracted by methanol. Three compounds were isolated using on Sephadex LH-20 and preparative glass-backed TLC plates. The compound's structure were characterized on the basis of spectroscopic data and by comparing their physicochemical and spectral data with those published in literatures. The cytotoxicity of three compounds was evaluated against four cancer cell lines: epithelial cancer (KB), liver (Hep G2); breast cancer (MCF-7) and lung (LU-1). We have been isolated three compounds. Their structures were identified as Goniothalamin (1), Aristolactam BII (2), 3-Methyl-1H-benz[f]indole-4,9-dione (3). Isolated compounds were tested cytotoxic activity against different cancer cell lines. The compound 1 demonstrated the highest potency against the epithelial cancer cell line with an IC50 of 4.18 ± 0.60μg/mL. Other compounds have weak cytotoxic activity. © 2016 Loi Vu Duc et al.

Tien V.N.,National Institute of Forensic Medicine | Duc L.V.,Vietnam National University, Hanoi | Thanh T.B.,Vietnam National University, Hanoi
Research Journal of Phytochemistry | Year: 2016

Nerium oleander L. is an evergreen shrub in the dogbane family Apocynaceae and planted throughout the tropical region. It has cardiotonic, antioxidant, anti-inflammatory and anticancer activities. Nerium oleander L. has high amount of cardiac glycoside and flavonoids compounds. From methanol extract of flowers of Nerium oleander L. grown in vietnam, it has been isolated four compounds. Their structures were identified as (1) D16-Dehydroadynerigenin, (2) D16-Digitoxigenin, (3) Quercetin and (4) Kaempferol on the basis of spectroscopic data and by comparing their physicochemical and spectral data with those published studies. The effect of fraction HF2, which containing compound 1 and 2 on heart function was examined, revealing potent positive inotropic effect on isolated rabbit heart by increasing the contractility and coronary flow heart but does not alter heart rate. © 2016 Academic Journals Inc.

PubMed | Ho Chi Minh City University of Technology, Vietnam National University, Ho Chi Minh City, University of Medicine and Pharmacy, Children Hospital 2 and 2 more.
Type: Journal Article | Journal: Journal of clinical neurology (Seoul, Korea) | Year: 2017

Dravet syndrome is a rare and severe type of epilepsy in infants. The heterogeneity in the overall intellectual disability that these patients suffer from has been attributed to differences in genetic background and epilepsy severity.Eighteen Vietnamese children diagnosed with Dravet syndrome were included in this study. SCN1A variants were screened by direct sequencing and multiplex ligation-dependent probe amplification. Adaptive functioning was assessed in all patients using the Vietnamese version of the Vineland Adaptive Behavior Scales, and the results were analyzed relative to the SCN1A variants and epilepsy severity.We identified 13 pathogenic or likely pathogenic variants, including 6 that have not been reported previously. We found no correlations between the presence or type of SCN1A variants and the level of adaptive functioning impairment or severity of epilepsy. Only two of nine patients aged at least 5 years had an adaptive functioning score higher than 50. Both of these patients had a low frequency of convulsive seizures and no history of status epilepticus or prolonged seizures. The remaining seven had very low adaptive functioning scores (39 or less) despite the variability in the severity of their epilepsy confirming the involvement of factors other than the severity of epilepsy in determining the developmental outcome.Our study expands the spectrum of known SCN1A variants and confirms the current understanding of the role of the genetic background and epilepsy severity in determining the developmental outcome of Dravet syndrome patients.

Shelef A.,Abarbanel Mental Health Center | Shelef A.,Tel Aviv University | Hiss J.,Tel Aviv University | Hiss J.,National Institute of Forensic Medicine | And 9 more authors.
International Journal of Geriatric Psychiatry | Year: 2014

Objectives The rate of completed suicide among the elderly continues to be the highest of any age group worldwide. The aim of the present study was to investigate the sociodemographic data, mental and physical health characteristics, and suicide methods of the elderly population who completed suicide in Israel. Methods A national retrospective record-based case series study of consecutive elder (50 years or older) suicide completers who had undergone autopsy over a 10-year period was conducted. Results Three hundred and fourteen consecutive records of suicide completers, 69.6% males, and mean age 64.7 were analyzed. The largest group (38%) emigrated from the Former Soviet Union and 19% emigrated from East Europe. Immigrants from East Europe committed suicide at an older age. Hanging was the predominant suicide method. Jumping from height increased more than threefold in the 'old-old'(older than 75 years) group. Hanging and firearms were more frequently used by males. Females were more likely to employ poisoning and suffocation. A significant minority (30%) had been diagnosed as suffering from psychiatric morbidity. Most common diagnoses were depression and alcohol abuse or dependence. Physical disorders (mainly cardiovascular disease and malignancy) were present in 27% of cases. Subjects with psychiatric illness were more likely to complete suicide at a younger age compared with subjects with physical illness. Conclusions Findings of male predominance, psychiatric morbidity, and physical illness are consistent with previously published studies. Immigrants from East Europe completed suicide at an older age and the older victims had used more lethal methods of suicide. Copyright © 2014 John Wiley & Sons, Ltd.

Almeida J.,Hospital S Francisco Xavier | Graca O.,National Institute of Forensic Medicine | Vieira F.,National Institute of Forensic Medicine | Almeida N.,National Institute of Forensic Medicine | Santos J.C.,National Institute of Forensic Medicine
Medicine, Science and the Law | Year: 2010

In Portugal, offenders found not guilty by reason of insanity (NGRI), may be given a restricted order to a special hospital as an alternative to prison. In European countries there is a recognized need for data concerning this special population. The aim of the present study was to examine the characteristics of all the NGRI subjects (n = 274) detained in the country in a descriptive and retrospective survey conducted in January 2009. Offence committed, demographic factors, diagnosis at admission, background of substance abuse and diagnostic stability were recorded. Schizophrenia was the commonest diagnosis (51.5%). Mean population age was 42.6 years, with only 6.2% women. Homicide was the most common offense (41.2%). A background of substance abuse was found in 42.3% of subjects. There were significant differences in the schizophrenia and mental retardation patient groups when compared individually with the other diagnoses concerning homicide and arson as the offence. Mean duration of inpatient stay did not differ significantly between diagnoses. The findings also point to poor follow-up of the NGRI patients after admission.

Battah A.Q.H.,University of Jordan | Al-Hadidi M.S.,National Institute of Forensic Medicine | Abdullat E.M.,University of Jordan | Hadidi K.A.,University of Jordan
Jordan Medical Journal | Year: 2013

Objective: Several studies have demonstrated that alcohol and psychoactive drugs consumption are important risk factors underlying fatal accidents. This paper presents a prospective and a pilot study for toxicological findings in road traffic accident fatality victims within the northern district of Amman in order to have an overall picture of the occurrence of these substances in the victims in Jordan. Method: Over a two-year period (2004-2005), 400 autopsies were conducted at Jordan University Hospital in which 94 (23.5%) were road traffic accident fatality victims. Biological specimens from these victims were collected. Toxicology screens for psychoactive drugs and alcohol were conducted on these specimens and the results were analyzed according to age, sex, and victim's status. Results: The data showed that ethanol and psychoactive drugs were positive in 72.3%, n = 68 and for ethanol alone 23.4%, n = 22. The majority of victims were the driver (n = 29) and the highest percentage of positive findings occurred among them (20.2%, n=19). Males in the age group 19-29 were mostly involved (35.7%). Detected psychoactive drugs were benzodiazepines, opioids, barbiturates and anti-depressants. None of the collected specimens were positive for illicit cocaine, amphetamines, or cannabis. Conclusions: The results of this study documented the presence of alcohol and psychoactive drugs in road traffic accident victims which could have some association between the uses of these substances and the accident involvement. However, due to some limitations, conclusions require further data collections, cooperation with related parties in Jordan, and utilizing simple and extended toxicological screens. © 2013 DAR Publishers̈M University of Jordan. All Rights Reserved.

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