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The Instituto Nacional de Engenharia, Tecnologia e Inovação , usually known as INETI for short, is a state-run R&D institution in Lisbon, Portugal, with scientific and technological activities in areas like new systems, processes and products; environmental and sustainable management; geological resources and risks; citizen protection, health and safety; space and defence; laboratory support and testing; etc.The Instituto Nacional de Engenharia, Tecnologia e Inovação carries out research, testing and technological development. Its mission is to promote technological innovation focused on science and technology with the overriding objective of raising company competitiveness within a framework of sustainable economic progress.Within the scope of competences attributed by Portuguese government strategies and policies for economic and social development, INETI takes up the role of an interface between the results generated by research and development programmes and their technological integration into the private sector .Its participation in a range of international projects positions it both as a key partner for internationalisation and a source of specialist information across its respective fields.INETI, as a Portuguese Ministry of Economy and Innovation entity, further serves as consultant for public policies in a diverse range of fields including: energy, the environment, sustainability, metrology, norms and certification. Wikipedia.


Duartea L.F.,University of Coimbra | Teixeira F.C.,National Institute of Engineering, Technology and Innovation | Faustoa R.,University of Coimbra
Arkivoc | Year: 2010

Bisphosphonates (BPs) are a class of drugs widely used in the treatment of several metabolic bone disorders associated with increased bone resorption. Although BPs can directly inhibit the cellular activity of osteoclasts, their ability to adsorb on bone mineral is also an important factor in determining their potency and duration of action. In this study, we performed a molecular mechanics analysis of the molecular structures of 18 novel hydroxy-and aminobisphosphonates and examined their interactions with hydroxyapatite. From the calculated interaction energies, general rules were extracted relating structural characteristics of BPs and their affinities to the mineral. The results obtained were shown to be in agreement with in vitro and in vivo studies performed for some of the studied BPs. Source


Alvaro J.J.,CSIC - National Institute of Aerospace Technology | Ezzouhairi H.,Chouaib Doukkali University | Ayad N.A.,Chouaib Doukkali University | Charif A.,Chouaib Doukkali University | And 2 more authors.
Precambrian Research | Year: 2010

In the Zenaga and Saghro inliers of the Anti-Atlas, Morocco, the Ediacaran Ouarzazate volcanosedimentary Supergroup preserves a record of the complex interplay between effusion of lava floods and explosive volcanic activity from numerous separate volcanic centres. Volcanic units consist of basaltic and andesitic, lava flows and subvolcanic sills and dikes, and dacitic/rhyolitic ignimbrites and tuffs that represent a post-collisional, high-K calc-alkaline magmatism. Volcanic events are separated by erosive and low-angle unconformities (related to regional tilting), which mark significant hiatii in the timing of deposition and are locally marked by carbonate production in palaeoweathered lowlands. Infill of scattered, decametre-scale, carbonate-bearing troughs, less than 1 km across, started with the dominantly local derivation of weathered and eroded lava debris, followed by the migration of scattered subaqueous bottomset and foreset structures, and final nucleation of carbonate productivity. Microbial mats developed along the shorelines of these ponds. When bathymetry increased the stromatolites developed domal to columnar morphologies that coalesced laterally to form metre-thick biostromes. The lack of evidence for significant fluvial and deltaic deposits suggests that the streams that entered the ponds were intermittent and thus not a significant source of water. It appears that groundwater, rather than surface water, was the dominant source of water to sustain the ephemeral ponds in the low-lying weathered palaeodepressions preserved in the Ouarzazate Supergroup. Fluids passing through the surrounding volcanic landscape and the volcanic ashes interbedded within the lacustrine infill supplied silica-enriched fluids, giving the ponds the characteristics of alkaline lake systems. Their lacustrine affinity is supported by the subaerial character of many of the volcanic products that surround them. REE composition of partly silicified, dolomitized and undolomitized stromatolites is entirely consistent with freshwater (lacustrine) or shallow lagoonal (with a strong freshwater input) depositional settings, but they also display a strong contamination from the rhyolitic tuffs that overly them. © 2010 Elsevier B.V. All rights reserved. Source


Neves M.,Technological and Nuclear Institute of Portugal | Teixeira F.C.,National Institute of Engineering, Technology and Innovation | Antunes I.,National Institute of Engineering, Technology and Innovation | Majkowska A.,Institute of Nuclear Chemistry and Technology of Poland | And 2 more authors.
Applied Radiation and Isotopes | Year: 2011

Introduction: Novel 1-hydroxy-1,1-bisphosphonates derived from indazole and substituted at the C-3 position were labeled with the radionuclides 46Sc and 153Sm. Several parameters such as molar ligand concentration, pH, reaction time and temperature were studied. The radiolabelling yield, reaction kinetics and stability were assessed and radiocomplexes were evaluated by in vitro and in vivo experiments. Methods: The radionuclides 46Sc and 153Sm were obtained by neutron irradiation of natural Sc2O3 and enriched 152Sm2O3 (98.4%) targets at the neutron flux of 3×1014ncm-2s-1. The radiolabelling yield, reaction kinetics and stability were accomplished by ascending instant thin layer chromatography. The radiocomplexes were submitted to in vitro experiments (hydroxyapatite binding and lipophilicity) and biodistribution studies in animal models. Results: The radionuclides 46Sc and 153Sm were produced with specific activities of 100 and 430MBqmg-1, respectively. High radiochemical yields were achieved and the hydrophilic radiocomplexes have shown high degree of binding to hydroxyapatite. Biodistribution studies at 1, 3 and 24h of the 4 radiocomplexes under study, have showed a similar biodistribution profile with a relatively high bone uptake, slow clearance from blood and a very slow rate of total radioactivity excretion from the whole animal body. Conclusion: We have developed a new class of indazolebisphosphonates complexes with radioisotopes of samarium and scandium. All complexes have shown high degree of binding to hydroxyapatite, which could be attributed to the ionized phosphonate groups. The bone uptake and the bone-to-muscle ratios were relatively low. © 2010 Elsevier Ltd. Source


Candido J.J.,University of Lisbon | Justino P.A.P.S.,National Institute of Engineering, Technology and Innovation
Renewable Energy | Year: 2011

Frequency-domain analysis is applied to a wave energy device composed of two coaxial axisymmetric bodies. For each frequency optimal damping coefficient values which maximize absorbed power are obtained. Several displacement amplitude restriction scenarios are considered. A stochastic model to describe the device's behaviour in irregular waves is developed. Optimal mechanical damping and spring coefficients are computed. Considering different sea state conditions, probability density functions are defined for relevant parameters and time-averaged absorbed power values are obtained. A time domain model is also developed for the device. A non-linear power take-off mechanism configuration, consisting in a hydraulic circuit with low-pressure and high-pressure gas accumulators, is devised. Time-averaged absorbed power is maximized in terms of characteristic mechanism parameter. A sub-optimal method of phase control by latching is applied to the device in order to improve its performance. Analytical development of Pontryagin Maximum Principle is used to establish an algorithm for device's control. © 2010 Elsevier Ltd. Source


Gonzalez-Fernandez O.,CSIC - Institute of Earth Sciences Jaume Almera | Batista M.J.,National Institute of Engineering, Technology and Innovation | Abreu M.M.,University of Lisbon | Queralt I.,CSIC - Institute of Earth Sciences Jaume Almera | Carvalho M.L.,University of Lisbon
X-Ray Spectrometry | Year: 2011

The chemical concentrations of 11 elements in 6 species of edible plants grown in 7 soils, developed in different gossanous materials of the abandoned mine area of Sao Domingos, in southern Portugal, was measured by energy dispersive X-ray fluorescence. The total fraction of elements in the soils from which the plants were sampled, was measured, using wavelength dispersive X-ray fluorescence. The elemental content in bioavailable fraction was obtained by using three different leaching tests: DIN 38414-S4, 1 M ammonium acetate and 0.005 M DTPA. Leachates were analyzed by Induced Coupled Plasma-Optical Emission Spectrometer (ICP-OES) and Induced Coupled Plasma-Mass Spectrometer (ICP-MS). The mineralogy of the same soils was evaluated by X-ray diffraction to identify the species present. The results show that levels in plants can be hazardous especially for Pb and As. Important concentrations of Fe and K were also observed. A different uptake was observed in the several plants for the different elements. The highest assimilation of metals was observed in sampling points containing soluble sulfate salts. © 2011 John Wiley & Sons, Ltd. Source

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