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Limban C.,Carol Davila University of Medicine and Pharmacy | Missir A.-V.,Carol Davila University of Medicine and Pharmacy | Chirita I.,Carol Davila University of Medicine and Pharmacy | Neagu A.,Carol Davila University of Medicine and Pharmacy | And 2 more authors.
Revista de Chimie | Year: 2011

2-(4-Fluoro-phenoxymethyl)benzoic acid thioureides were prepared from the reaction of 2-(4-fluoro-phenoxymethyl)benzoyl isothiocyanate with various primary aromatic amines. These new compounds were characterized by their physical properties (melting point, solubility), the structures were confirmed by elemental analysis, 1H-NMR, 13C-NMR, IR and UV-Vis spectral methods, and then were tested by qualitative and quantitative methods on various microbial and fungal strains and proved to be active at low concentrations on gram positive, gram negative bacteria and fungi. Source


Chifiriuc M.C.,National Institute for Research in Microbiology and Immunology Cantacuzino | Stecoza C.,Carol Davila University of Medicine and Pharmacy | Veronica L.,National Institute for Research in Microbiology and Immunology Cantacuzino | Dracea O.,National Institute for Research in Microbiology and Immunology Cantacuzino | And 2 more authors.
Romanian Biotechnological Letters | Year: 2010

In the search of bioactive molecules, a series of O-acyloximino-dibenzo[b,e]thiepins and Oacyloximino-dibenzo[b,e]thiepin-5,5-dioxides have been synthesized in several stages, obtaining Oacyl-oximino-dibenzo[b,e]thiepins 1. The sulfones 2 were obtained by the oxidation of O-acyloximinodibenzo[b,e]thiepins 1 with hydrogen peroxide in acetic acid, at boiling temperature. The new compounds were characterized by spectroscopic data and elemental analyses and were evaluated for their antimicrobial activities. The tested compounds exhibited specific antimicrobial activity against different bacterial and fungal strains, recently isolated from clinical samples and exhibiting resistance features to conventional antibiotics, with MIC values ranging from 1000 to 15.6 μg/mL. © 2010 University of Bucharest. Source


Limban C.,Carol Davila University of Medicine and Pharmacy | Missir A.-V.,Carol Davila University of Medicine and Pharmacy | Chirita I.C.,Carol Davila University of Medicine and Pharmacy | Guta R.,Romanian National Institute for Chemical Pharmaceutical Research and Development | And 6 more authors.
Revue Roumaine de Chimie | Year: 2010

The paper reports on the synthesis of some new 2-methoxy-O-acyl-oximino- dibenz[b,e]oxepins. The new compounds and the intermediary substances were characterized by spectroscopic data and elemental analyses. Their antibacterial activities were investigated. Source


Limban C.,Carol Davila University of Medicine and Pharmacy | Missir A.V.,Carol Davila University of Medicine and Pharmacy | Chirita I.C.,Carol Davila University of Medicine and Pharmacy | Nitulescu G.M.,Carol Davila University of Medicine and Pharmacy | And 2 more authors.
Chemical Papers | Year: 2011

New acylthiourea derivatives, 2-((4-ethylphenoxy)methyl)-N- (phenylcarbamothioyl)benzamides, were tested by qualitative and quantitative methods on various bacterial and fungal strains and proved to be active at low concentrations against Gram-positive and Gram-negative bacteria as well as fungi. These compounds were prepared by the reaction of 2-((4-ethylphenoxy) methyl)benzoyl isothiocyanate with various primary aromatic amines, and were characterised by melting point and solubility. The structures were identified by elemental analysis, 1H and 13C NMR, and IR spectral data. The level of antimicrobial activity of the new 2-((4-ethylphenoxy)methyl) benzoylthiourea derivatives was dependent on the type, number and position of the substituent on the phenyl group attached to thiourea nitrogen. The iodine and nitro substituents favoured the antimicrobial activity against the Gram-negative bacterial strains, while the highest inhibitory effect against Gram-positive and fungal strains was exhibited by compounds with electron-donating substituents such as the methyl and ethyl groups. © 2011 Institute of Chemistry, Slovak Academy of Sciences. Source

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