National Institute for Parasitic Diseases

Shanghai, China

National Institute for Parasitic Diseases

Shanghai, China
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Li C.,Shanghai JiaoTong University | Cheng L.,Shanghai JiaoTong University | Zhang Y.,Shanghai JiaoTong University | Guo S.,Shanghai JiaoTong University | Wu W.,National Institute for Parasitic Diseases
International Journal of Pharmaceutics | Year: 2010

Praziquantel (PZQ)-loaded poly(ε-caprolactone) (PCL) cylindrical implants were fabricated and characterized. Implant diameter (3, 4 and 8 mm), drug loading (25% and 50%), and the end-capping were investigated to evaluate their effects on drug release. The evolution of implants with release time was conducted in terms of implant microstructure, crystallinity, drug content and molecular weight of PCL. The results showed that drug release was fastest for the implant with a diameter of 3 mm and slowest for the implant with a diameter of 8 mm; drug release from the implant with a drug content of 50% was faster than that from the implant with a drug content of 25%; the release of PZQ from the end-capped implants was slightly slower than that from the corresponding end-uncapped implants. The effect of drug loadings on PZQ release was related with diameter of the implants and the effect was weakened as diameter of the implants increased. The drug release data for all the implants were best fitted with Ritger-Peppas model, therefore Fickian diffusion was the predominant release mechanism. The evolution of implants with release time verified that PZQ was gradually released from the exterior to the interior of the implants. © 2009 Elsevier B.V. All rights reserved.


Wang R.,Henan Agricultural University | Qiu S.,Henan Agricultural University | Jian F.,Henan Agricultural University | Zhang S.,Henan Agricultural University | And 6 more authors.
Parasitology Research | Year: 2010

The distribution and public health significance of Cryptosporidium species/genotypes in pigs differ among geographic areas and studies. To characterize the prevalence of cryptosporidiosis in pigs in Henan, China, a total of 1,350 fecal samples from 14 farms in ten prefectures in Henan Province were examined. The overall prevalence of Cryptosporidium was 8.2% (111/1,350), with the highest infection rate (79/383 or 20.6%) in 1-2-month-old piglets and the lowest infection rates in 3-6-month-old pigs. Cryptosporidium-positive samples from 108 animals were analyzed by polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis of the small subunit rRNA gene, and 35 were further analyzed by DNA sequencing of the PCR products. Two Cryptosporidium species/genotype were identified, including Cryptosporidium suis (94/108) and the Cryptosporidium pig genotype II (14/108). C. suis infection was more common in younger piglets whereas the pig genotype II was relatively common in older pigs. These findings suggest that pigs are not a major source of zoonotic Cryptosporidium in the study area. © 2010 Springer-Verlag.


Duan L.P.,National Institute for Parasitic Diseases | Zhao Q.F.,Shanghai Normal University | Zhang H.B.,National Institute for Parasitic Diseases
Arabian Journal of Chemistry | Year: 2010

A series of S(-)-2-(4-chlorophenyl)-N-(5,7-disubstituted-2H-[1,2,4]-thiadiazolo[2,3-a]pyrimidin-2-ylidene)-3-methylbutanamide derivatives were designed and synthesized. The structures of all the newly synthesized compounds had been identified by elemental analysis, 1H NMR, MS and optical rotation. Their herbicidal activities were evaluated against a variety of weeds. The preliminary results showed that most of the target compounds had moderate inhibitory activities and selectivities against root and stalk of monocotyledon and dicotyledon plants. More importantly, the chiral target compounds showed improved herbicidal activities to some extent over their racemic counterparts against a variety of tested weeds, which might be contributed by the introduction of chiral active unit. The present work provided a novel class of chirality-based thiadiazolopyrimidine derivatives with potent herbicidal activities for further optimization. © 2010 .


Duan L.-P.,National Institute for Parasitic Diseases | Xue J.,National Institute for Parasitic Diseases | Xu L.L.,National Institute for Parasitic Diseases | Zhang H.-B.,National Institute for Parasitic Diseases
Molecules | Year: 2010

A series of 1-acyl-3-(2'-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, 1H-NMR and 13C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were evaluated in rats by an oral route. Among these compounds, at concentrations of 10 mg/kg of rat, compound (1-(2'-furanyl)acyl-3- (2'- aminophenyl) thiourea) (5h) produced the highest activity with 89.4% deparasitization. The present work suggests that 1-acyl-3-(2'-aminophenyl) thiourea derivatives may nbecome useful lead compounds for anti-intestinal nematode treatment. © 2010 by the authors.


Ma X.-L.,National Institute for Parasitic Diseases | Zhang Y.,National Institute for Parasitic Diseases
Chinese Journal of Schistosomiasis Control | Year: 2012

Peroxiredoxin (Prx) belongs to a peroxidase family of antioxidant enzymes distributed ubiquitously in aerobic organisms such as yeast, fungi, parasites, mammals and humans. It plays an important role in the defense of reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by aerobic organisms. This article introduces the classification, mechanism of Prx and the progress of research on Prx in invertebrates.


Xiong Y.-H.,National Institute for Parasitic Diseases | Zheng B.,National Institute for Parasitic Diseases
Chinese Journal of Schistosomiasis Control | Year: 2014

This study analyzes the strength, weakness, opportunity and threat (SWOT) of laboratory certification and accreditation on detection of parasitic diseases by SWOT analysis comprehensively, and it puts forward some development strategies specifically, in order to provide some indicative references for the further development.


Duan L.P.,National Institute for Parasitic Diseases | Zhang H.B.,National Institute for Parasitic Diseases
Arabian Journal of Chemistry | Year: 2011

A series of thiosemicarbazones of aromatic iodide derivatives were designed and synthesized. The structures of all the newly synthesized compounds had been identified by elemental analysis, 1H NMR and 13C NMR. Their biological activities were evaluated against Plasmodium falciparum. Among these compounds, at concentrations of 3, 9 and 27mg/kg of mouse per day, 4e inhibited the growth of the malaria parasite in vivo test in mice with the respective percentages: 88.1%, 90.7% and 92.6%. The present work suggest that thiosemicarbazones of aromatic iodide may become a lead compound for anti-malaria medicine. © 2010.


Ma X.L.,National Institute for Parasitic Diseases
Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control | Year: 2012

Peroxiredoxin (Prx) belongs to a peroxidase family of antioxidant enzymes distributed ubiquitously in aerobic organisms such as yeast, fungi, parasites, mammals and humans. It plays an important role in the defense of reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by aerobic organisms. This article introduces the classification, mechanism of Prx and the progress of research on Prx in invertebrates.


PubMed | National Institute for Parasitic Diseases
Type: Journal Article | Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control | Year: 2012

Peroxiredoxin (Prx) belongs to a peroxidase family of antioxidant enzymes distributed ubiquitously in aerobic organisms such as yeast, fungi, parasites, mammals and humans. It plays an important role in the defense of reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by aerobic organisms. This article introduces the classification, mechanism of Prx and the progress of research on Prx in invertebrates.


Wu A.,National Institute for Parasitic Diseases | Wu A.,Yangtze University | Duan L.,National Institute for Parasitic Diseases
Turkish Journal of Chemistry | Year: 2011

A heptamethine cyanine-based sensor (1) was designed and synthesized by incorporating heptamethine cyanine fluorophore and methylpiperazine. Sensor 1 exhibited good response to the change of pH levels, and a large Stokes shift (>100 nm) was obtained. Fluorescent image experiments in living cells further demonstrated its potential applications in biological systems. © TÜBİTAK.

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