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Wang R.,Henan Agricultural University | Qiu S.,Henan Agricultural University | Jian F.,Henan Agricultural University | Zhang S.,Henan Agricultural University | And 6 more authors.
Parasitology Research | Year: 2010

The distribution and public health significance of Cryptosporidium species/genotypes in pigs differ among geographic areas and studies. To characterize the prevalence of cryptosporidiosis in pigs in Henan, China, a total of 1,350 fecal samples from 14 farms in ten prefectures in Henan Province were examined. The overall prevalence of Cryptosporidium was 8.2% (111/1,350), with the highest infection rate (79/383 or 20.6%) in 1-2-month-old piglets and the lowest infection rates in 3-6-month-old pigs. Cryptosporidium-positive samples from 108 animals were analyzed by polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis of the small subunit rRNA gene, and 35 were further analyzed by DNA sequencing of the PCR products. Two Cryptosporidium species/genotype were identified, including Cryptosporidium suis (94/108) and the Cryptosporidium pig genotype II (14/108). C. suis infection was more common in younger piglets whereas the pig genotype II was relatively common in older pigs. These findings suggest that pigs are not a major source of zoonotic Cryptosporidium in the study area. © 2010 Springer-Verlag.


Tao Y.,National Institute for Parasitic Diseases | Duan L.,National Institute for Parasitic Diseases | Li Q.,National Institute for Parasitic Diseases | Xu T.,Extry Exit Inspection and Quarantine Bureau | Zhang H.,National Institute for Parasitic Diseases
Sensor Letters | Year: 2014

An "off-on"-type fluorescent chemosensor acylthiourea based on Rhodamine-B for selective recognition and determination of Hg2+, Zn2+, Cd2+, Pb2+ and Al3+ had a negligible interfering effect on Hg2+ sensing by fluorescent chemosensor. Furthermore, the proposed chemosensor has been used for direct measurement of Hg2+ in skin, as sensitivity requirements, compared to that of mass-spectrometric methods, the sensor gives satisfied result in real cosmetic products samples. Copyright © 2014 American Scientific Publishers


Duan L.P.,National Institute for Parasitic Diseases | Zhao Q.F.,Shanghai Normal University | Zhang H.B.,National Institute for Parasitic Diseases
Arabian Journal of Chemistry | Year: 2010

A series of S(-)-2-(4-chlorophenyl)-N-(5,7-disubstituted-2H-[1,2,4]-thiadiazolo[2,3-a]pyrimidin-2-ylidene)-3-methylbutanamide derivatives were designed and synthesized. The structures of all the newly synthesized compounds had been identified by elemental analysis, 1H NMR, MS and optical rotation. Their herbicidal activities were evaluated against a variety of weeds. The preliminary results showed that most of the target compounds had moderate inhibitory activities and selectivities against root and stalk of monocotyledon and dicotyledon plants. More importantly, the chiral target compounds showed improved herbicidal activities to some extent over their racemic counterparts against a variety of tested weeds, which might be contributed by the introduction of chiral active unit. The present work provided a novel class of chirality-based thiadiazolopyrimidine derivatives with potent herbicidal activities for further optimization. © 2010 .


Duan L.-P.,National Institute for Parasitic Diseases | Xue J.,National Institute for Parasitic Diseases | Xu L.L.,National Institute for Parasitic Diseases | Zhang H.-B.,National Institute for Parasitic Diseases
Molecules | Year: 2010

A series of 1-acyl-3-(2'-aminophenyl) thiourea derivatives were designed and synthesized. The structures of all the newly synthesized compounds were identified by IR, elemental analysis, 1H-NMR and 13C-NMR. Their anti-intestinal nematode activities against Nippostrongylus brazilliensis were evaluated in rats by an oral route. Among these compounds, at concentrations of 10 mg/kg of rat, compound (1-(2'-furanyl)acyl-3- (2'- aminophenyl) thiourea) (5h) produced the highest activity with 89.4% deparasitization. The present work suggests that 1-acyl-3-(2'-aminophenyl) thiourea derivatives may nbecome useful lead compounds for anti-intestinal nematode treatment. © 2010 by the authors.


Ma X.-L.,National Institute for Parasitic Diseases | Zhang Y.,National Institute for Parasitic Diseases
Chinese Journal of Schistosomiasis Control | Year: 2012

Peroxiredoxin (Prx) belongs to a peroxidase family of antioxidant enzymes distributed ubiquitously in aerobic organisms such as yeast, fungi, parasites, mammals and humans. It plays an important role in the defense of reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by aerobic organisms. This article introduces the classification, mechanism of Prx and the progress of research on Prx in invertebrates.


Xiong Y.-H.,National Institute for Parasitic Diseases | Zheng B.,National Institute for Parasitic Diseases
Chinese Journal of Schistosomiasis Control | Year: 2014

This study analyzes the strength, weakness, opportunity and threat (SWOT) of laboratory certification and accreditation on detection of parasitic diseases by SWOT analysis comprehensively, and it puts forward some development strategies specifically, in order to provide some indicative references for the further development.


Duan L.P.,National Institute for Parasitic Diseases | Zhang H.B.,National Institute for Parasitic Diseases
Arabian Journal of Chemistry | Year: 2011

A series of thiosemicarbazones of aromatic iodide derivatives were designed and synthesized. The structures of all the newly synthesized compounds had been identified by elemental analysis, 1H NMR and 13C NMR. Their biological activities were evaluated against Plasmodium falciparum. Among these compounds, at concentrations of 3, 9 and 27mg/kg of mouse per day, 4e inhibited the growth of the malaria parasite in vivo test in mice with the respective percentages: 88.1%, 90.7% and 92.6%. The present work suggest that thiosemicarbazones of aromatic iodide may become a lead compound for anti-malaria medicine. © 2010.


Ma X.L.,National Institute for Parasitic Diseases
Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control | Year: 2012

Peroxiredoxin (Prx) belongs to a peroxidase family of antioxidant enzymes distributed ubiquitously in aerobic organisms such as yeast, fungi, parasites, mammals and humans. It plays an important role in the defense of reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by aerobic organisms. This article introduces the classification, mechanism of Prx and the progress of research on Prx in invertebrates.


PubMed | National Institute for Parasitic Diseases
Type: Journal Article | Journal: Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control | Year: 2012

Peroxiredoxin (Prx) belongs to a peroxidase family of antioxidant enzymes distributed ubiquitously in aerobic organisms such as yeast, fungi, parasites, mammals and humans. It plays an important role in the defense of reactive oxygen species (ROS) and reactive nitrogen species (RNS) produced by aerobic organisms. This article introduces the classification, mechanism of Prx and the progress of research on Prx in invertebrates.


Wu A.,National Institute for Parasitic Diseases | Wu A.,Yangtze University | Duan L.,National Institute for Parasitic Diseases
Turkish Journal of Chemistry | Year: 2011

A heptamethine cyanine-based sensor (1) was designed and synthesized by incorporating heptamethine cyanine fluorophore and methylpiperazine. Sensor 1 exhibited good response to the change of pH levels, and a large Stokes shift (>100 nm) was obtained. Fluorescent image experiments in living cells further demonstrated its potential applications in biological systems. © TÜBİTAK.

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