National Institute for Nutrition and Health

Beijing, China

National Institute for Nutrition and Health

Beijing, China
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News Article | May 22, 2017

BEIJING, May 22, 2017 /PRNewswire/ -- As we get older, we are not only increasingly eager to maintain our young look, but we also hope that our brain response and memory remain good as well. Fortunately, with the development of science and technology, the scientific research products dealing with brain health of the middle-aged and elderly might make it possible to "keep the brain spry". During the 13th China Nutrition Science Congress held by the Chinese Nutrition Society, Nestle launched "Nestle YIYANG Fuel for brainTM senior milk powder" a new innovative product in the Chinese market. The product is specially designed to help people over 50 years old "refuel their brains and start a new smart life". Developing a healthy lifestyle and protecting your brain as you age China is facing a very grim aging trend. As shown by 2010 demographic census data, the population over the age of 50 accounted for 28.3% of the total population; as of 2016, there were 350 million people over 50 years old, accounting for 25% of the total population; by 2050, this proportion may reach 50%. According to Wenhua ZHAO, deputy director of National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, the aging of the population, or extended average life expectancy, is the inevitable result of societal progress and development. Middle-aged people and the elderly should pay attention to a balanced intake of nutrients and development of a healthy lifestyle. According to scientific research, the human brain does not produce its energy, it needs to take in glucose, which is the main energy source, continuously from blood as fuel. When people get older, they tend to have slower reaction times, decreased memory and sometimes they feel their brain cannot fully function. This may be partially associated with the fact that as we age, glucose intake ability and use decreases so that the brain cannot get enough fuel to function optimally. Another alternative source of brain energy comes from ketone, i.e., when there is lack of energy, ketone as the metabolite of fat, can be taken as alternative energy directly for brain. Guowei HUANG, brain health expert and dean of School of Public Health, Tianjin Medical University said, "Compared with healthy young people, the brain of the elderly utilizes glucose at only 85-90% the rate of young people while patients with Alzheimer's disease utilize only around 75%. Studies have shown that medium chain triglyceride (MCT) can be converted into ketone bodies and serve as an alternative source of energy for the minds of the elderly." Experts believe that reasonable nutritional supplements for the brain help to delay aging and prevent and control various geriatric diseases, so as to achieve the goal of good health and longevity and improved quality of life. Compared with long chain triglyceride, MCT (medium chain triglyceride) is easier for intake and metabolism. It can rapidly release energy to quickly provide the brain with energy and nutrients. In the case of under-utilization of glucose, MCT can directly supply energy to the brain in lieu of glucose, supporting the brain's normal energy needs without being stored as fat in the body. MCT naturally exists in lauric oils such as coconut oil, which is a natural plant source ingredient. MCT has been early applied in medical care products with special needs, like milk powder for premature babies, sports energy products etc. Additionally, MCT has shown potential in research in the treatment of neurodegenerative diseases such as Alzheimer's disease. "Nestle YIYANG Fuel for brainTM senior milk powder" contains MCT which can be efficiently converted into ketone, the energy required by brain, to 'feed' the brain. This is why the milk powder is named "Fuel for Brain," said Marianne Tsanis, vice president of Dairy Business Unit, Nestle Greater China. At present, Chinese people tend to place great emphasis on treatment while placing little emphasis on prevention; however, prevention is more important than treatment for chronic disease management. As a world leader in "Nutrition, Health and Wellness", Nestle is deeply aware that with an increase of age, people need to pay more attention to their daily nutrition intake. Dr. Fabrizio Arigoni, head of Nestle Research Center Asia, will deliver a speech on the challenges of aging from a nutrition and health viewpoint at Aging Nutrition and Successful Aging Session of China Nutrition Science Congress and will emphasize the role that diet can play in preventing the onset of age related diseases.  After 50 years old of age, people particularly need nutritious food that meets their age characteristics so as to maintain good health and quality of life. To care for the elderly, in addition to encouraging them to actively participate in physical fitness activities, it is equally important to help them supplement nutritions and build a scientific nutrition structure. The launch of "Nestle YIYANG Fuel for brainTM senior milk powder" is another move to express deep concern for the elderly. Nestle has specially put forward a new concept of "happy aging" for people above 50 years old. Under this concept, the middle-aged and the elderly are encouraged to actively pursue quality of life and merrily enjoy their life. "As an old Chinese saying goes, 'Diet cures more than the doctors'. Nestle YIYANG has always been committed to providing healthy ideas and nutrition programs for people above 50 years old. We advocate the middle-aged and the elderly to be more proactive in managing their own health, and we also call on everyone no matter what age to pay more attention to their nutrition and health," said Marianne Tsanis, vice president of Dairy Business Unit, Nestle Greater China. As the largest food company and a leading company committed to "Nutrition, Health and Wellness", Nestle has been providing nutritious and healthy food for consumers for more than 150 years. Relying on its industry leading research and development capabilities, the network that comprises of 40 centers, Nestle tailors nutrient formula of dairy products for population groups of various ages. Nestle YIYANG is tailored for Chinese consumers above 50 years old according to their physical characteristics with an aim to provide them with better health and more vitality and enable more possibilities. Nestle YIYANG has launched three milk powder products for middle-aged and elderly in China, i.e., Nestle YIYANG Jianxin Gold 2-in-1 Formula Senior milk powder, Nestle YIYANG Omega 3:6 Jianxin Senior milk powder and Nestle YIYANG Protects(Yi Hu Yin Zi)Senior milk powder Plus the newly launched " Nestle YIYANG Fuel for brainTM senior milk powder", Nestle YIYANG brand has had four milk powder for middle-aged and the elderly for bones, heart, digestive health and cognitive ability, all of which are the health problems most concerned about by people above 50 years old. Nestle YIYANG cherishes the demand of middle-aged and elderly people to pursue "happy aging" and helps these people above 50 years old to have a longer and younger state through reasonable dietary nutrition and a healthy lifestyle.

Wang H.,National Institute for Nutrition and Health
International Journal of Obesity | Year: 2017

Background:Research on the shift in children's body mass index (BMI) distribution is limited and conditional mean models used in the previous research have limitations in capturing cross-distribution variations in effects. The objectives are to analyze the shift in Chinese children’s BMI distribution and to test the associations between BMI distribution and other factors.Methods:We analyzed data collected from children 7 to 17 years old from the China Health and Nutrition Survey (CHNS) conducted in 1997, 2000, 2004, 2006, 2009 and 2011, from 2814 participants with 6799 observations. Longitudinal quantile regression (QR) was used to explore the effect of several factors on BMI trends in 2015.Results:The BMI curves shift to the right in boys and girls, with the distributions becoming wider, indicating a higher proportion of children have become overweight. The 5th, 15th, 50th, 85th and 95th BMI percentile curves all shifted upward from 1997 to 2011, and the higher percentiles had greater increases. The prevalence of overweight and obesity increased in boys and girls between 1997 and 2011, from 6.5 to 15.5% in boys and from 4.6 to 10.4% in girls. Energy intake and parents’ BMI levels had a positive association with children’s BMI. Per capita income was positively associated with changes in BMI only at the upper percentiles of the BMI distributions in boys. Increased physical activity (PA) was associated with decreased BMI in girls.Conclusions:Children in China are becoming increasingly overweight. Energy intake, parental BMI, PA and early menarche age in girls are associated with elevated BMI in children.International Journal of Obesity advance online publication, 21 March 2017; doi:10.1038/ijo.2017.53. © 2017 Macmillan Publishers Limited, part of Springer Nature.

Jia P.,University of Twente | Xue H.,Ball State University | Zhang J.,National Institute for Nutrition and Health | Wang Y.,Ball State University
International Journal of Environmental Research and Public Health | Year: 2017

Childhood overweight and obesity (ow/ob) has become a serious threat to many countries, including China. However, limited evidence was obtained from longitudinal data in China. This study examined the secular trends and geographic variation in the prevalence of ow/ob and obesity only, and age, gender, and urban-rural disparities among school-aged children across China. Data from children aged 6–17 surveyed in China Health and Nutrition Survey (CHNS) from 1991 (n = 2712) to 2011 (n = 1054) were used. Overweight and obesity were defined based on the International Obesity Task Force (IOTF) recommended Asian age-sex-specific BMI cut-off-points. We found that: (1) childhood ow/ob and obesity prevalence increased from 11.7% to 25.2% and from 2.8% to 10.1% during 1991–2011, respectively; (2) children aged 6–12 experienced a 1.3 and 1.6 times increase in ow/ob and obesity prevalence than children aged 13–17, respectively; (3) the urban-rural gap in ow/ob prevalence widened; (4) ow/ob prevalence in boys was higher and increased faster than in girls, especially in an urban setting; and (5) geographic variation was observed with faster increases in more economically developed east, central and northeast regions than in the less developed west. The findings added more nuances to the picture of temporal changes in ow/ob prevalence among Chinese children. © 2017 by the authors.

Jorgensen J.M.,University of California at Davis | Yang Z.,National Institute for Nutrition and Health | Lonnerdal B.,University of California at Davis | Chantry C.J.,University of California at Davis | Dewey K.G.,University of California at Davis
Journal of Nutrition | Year: 2017

Background: Ferritin and hepcidin are markers of iron status that typically increase during inflammation or infection. The postpartum period is a physiologically unique life stage in which the relations between these proteins and other markers of inflammation have not been extensively studied. Objective: We aimed to determine whether 2 markers of inflammation [high-sensitivity C-reactive protein (CRP) and α1-acid glycoprotein (AGP)] were associated with ferritin or hepcidin in postpartum women in California. Methods: This is a secondary analysis of a randomized controlled iron-intervention trial. Plasma CRP, AGP, ferritin, and hepcidin were analyzed at 2 and 17 wk postpartum in 114 lactating women. We examined Pearson correlation coefficients between all biomarkers at both time points and differences in mean values of ferritin and hepcidin between those with and without elevated CRP and/or AGP. Results: At 2 and 17 wk postpartum, 58% and 26% of women had CRP > 5 mg/L and 78% and 29% had AGP > 1 g/L, respectively. Neither CRP nor AGP was significantly correlated with ferritin (r = 0.07 and20.06; n = 114 at 2 wk;20.14 and 20.14; n = 95 at 17 wk) or hepcidin (r = 0.18 and 20.03 at 2 wk; 20.05 and 20.14 at 17 wk; P > 0.05 for all). At 2 wk, geometric mean plasma ferritin and hepcidin concentrations did not differ between women with and without elevated CRP or AGP (P > 0.5), but at 17 wk women with elevated CRP or AGP had lower mean (95% CI) ferritin and hepcidin than did women without either elevated CRP or AGP [ferritin: 30.3 ng/mL (23.4, 39.1 ng/mL) compared with 40.2 ng/mL (32.9, 49.2 ng/mL); P < 0.01; hepcidin: 44.3 ng/mL (32.3, 60.9 ng/mL) compared with 67.6 ng/mL (56.1, 81.5 ng/mL); P = 0.02]. Conclusion: Lower ferritin and hepcidin among women with elevated CRP or AGP at 17 wk postpartum suggests that these markers of iron status react differently to physiologic immune activation than to pathologic inflammatory states. © 2017 American Society for Nutrition.

Zhang S.-Q.,Beijing Technology and Business University | Zhang S.-Q.,National Institute for Nutrition and Health | Zhang H.-B.,Hubei Provincial Key Laboratory of Yeast Function | Zhang Y.,Hubei Provincial Key Laboratory of Yeast Function
Food Chemistry | Year: 2018

The in vivo determination of selenomethionine (SeMet) converted from selenium-enriched yeast (SeY) rather than the determination of in vitro hydrolyzed SeMet is a better parameter for the evaluation of SeY quality. A UPLC–MS/MS method was developed for the quantification of SeMet in rat plasma and the oral bioavailability of SeMet converted from SeY in rats. After a simple extraction with perchloric acid, SeMet and the internal standard methylselenocysteine (MSC) were separated on a C18 column with isocratic elution of water:acetonitrile:formic acid (99:1:0.1, v/v/v) and detected in the multiple reaction monitoring mode. The method was accurate (92.6–104.3%) and precise (1.8–11.0%), and the recovery was 79.4–95.4%. It was successfully applied to pharmacokinetic and bioavailability studies of SeY in rats following the intravenous administration of SeMet and intragastric administration of SeY. SeMet in vivo, converted from SeY, is reported for the first time, and the results suggested that the SeY bioavailability in rats is 87%. © 2017 Elsevier Ltd

Zhang J.,National Institute for Nutrition and Health | Wang H.,National Institute for Nutrition and Health | Wang Z.,National Institute for Nutrition and Health | Zhang B.,National Institute for Nutrition and Health
Nutrients | Year: 2017

Previous studies have showed an inverse association between magnesium level and type 2 diabetes, but the results are inconsistent, and the evidence relates only to dietary and serum magnesium. Moreover, it is not certain how these findings are applicable to Asian people. This study was designed to examine the association between toenail magnesium and type 2 diabetes in Chinese adults. The sample was 5683 adults aged 18 years or older from the 2009 China Health and Nutrition Survey. We used hemoglobin A1c equal to or greater than 6.5% as the diagnostic criterion for type 2 diabetes. Inductively coupled plasma–mass spectrometry determined toenail magnesium. Mean toenail magnesium in participants with and without type 2 diabetes was 263.0 ± 170.9 and 282.3 ± 191.9 micrograms per gram, respectively. The multivariable-adjusted odds ratio for type 2 diabetes comparing the highest to the lowest quartile of toenail magnesium was 0.72 (95% confidence interval, 0.52–0.99). We found a statistically significant interaction between toenail magnesium and geographic region on the prevalence of type 2 diabetes (p for interaction = 0.009). Our findings suggest that toenail magnesium is inversely associated with the prevalence of type 2 diabetes. Promoting the intake of magnesium-rich foods may bring considerable benefits for the prevention of type 2 diabetes, especially in those at high risk. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.

Zhang S.-Q.,National Institute for Nutrition and Health
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences | Year: 2015

Icaritin (ICT), a bioactive metabolite of prenylflavonoids from genus Epimedium, has displayed potential benefits for the treatment of osteoporosis, prostate cancer, liver cancer, renal cancer and breast cancer. To investigate the quantity of ICT in bones in vivo, a simple and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed. After a rapid one-step liquid-liquid extraction using ethyl acetate with recovery more than 87.2% at four levels (0.1, 0.2, 8 and 15ng/mL), ICT and internal standard coumestrol were analyzed on a C18 column using a gradient elution of acetonitrile and water containing ammonium formate and formic acid at a flow rate of 0.3mL/min. Quantification was performed using selected reaction monitoring mode to monitor precursor-product ion transitions of m/z 367.1→297.1 for ICT and of 267.0→211.1 for coumestrol in the negative ionization mode. A calibration curve with good linearity (r>0.99) within the concentration range of 0.1-20ng/mL for ICT was obtained with the lower limit of quantification of 0.1ng/mL. Matrix effect did not interfere with ICT analysis and ICT was stable under three freeze-thaw cycles, short-term temperature, post-preparative and long-term temperature conditions. The method was successfully applied to a dynamic distribution of ICT in mouse bone after a single intraperitoneal administration to ICT to mice. © 2014 Elsevier B.V.

Icaritin (ICT), a major component in herb Epimedium brevicornum Maxim., shows beneficial effects for the treatment of osteoporosis and various cancers, and is predominantly metabolized to glucuronidated icaritin (GICT). Although clinical trials of ICT have exhibited good safety and tolerance, the dynamic bioditributions of ICT and GICT have not been reported. In the present study, the chemical structure of GICT was firstly reported, and a reliable ultra-high performance liquid chromatography-tandem mass spectrometry method (UHPLC-MS/MS) was firstly established for the simultaneous quantifications of ICT and GICT in rat tissues. The dynamic distribution of ICT and GICT in rat tissues and their pharmacokinetic parameters have been reported for the first time. ICT, GICT and the internal standard coumestrol were separated on a C18 column with a gradient mobile phase of acetonitrile and water containing ammonium formate and formic acid at a flow rate of 0.3 mL min-1. The analytes were quantified by a triple quadrupole tandem mass spectrometer in the negative ionization mode. The lower limit of quantification values for ICT and GICT were 0.2 and 2 ng mL-1, respectively. Good selectivity, linearity, accuracy, precision and recovery were achieved, and no significant matrix effect was observed. The UHPLC-MS/MS was firstly applied to a dynamic biodistribution study of ICT and GICT in rats, following an intraperitoneal administration of ICT at a dose of 10 mg kg-1. 2016. © The Japan Society for Analytical Chemistry.

Ding G.,National Institute for Nutrition and Health | Gao J.,National Institute for Nutrition and Health
Journal of Chinese Institute of Food Science and Technology | Year: 2016

There are two points in the development of nutrition, nutrition research and nutrition improvement. We have a long history in nutrition research. This paper reviewed the development process of nutrition research in China, from the preliminary ancient understandingto the establishment of the nutrition work now. The nutrition research is developed for the nutrition improvement of human being, so the nutritional status of Chinese residents in recent two decades was summarized, and the opportunities and challenges of the nutrition work in China were proposed in this paper. © 2016, Editorial Office of Journal of CIFST. All right reserved.

Chen X.,National Institute for Nutrition and Health
Journal of Occupational and Environmental Medicine | Year: 2016

OBJECTIVE:: To understand the association of domain-specific physical activity (PA) with leisure-time sedentary behavior (LTSB) among Chinese professionals. METHODS:: Totally, 3326 workers aged 35 to 64 years old from Beijing city and Zhejiang province were asked information on domain-specific PA with a revised Global Physical Activity Questionnaire (GPAQ). The association of domain-specific PA with LTSB-lifestyle (≥4?hours/day spent on LTSB) was examined with a binary logistic regression model. RESULTS:: Compared with sedentary occupational activity (OA), light-, moderate-, and vigorous-intensity OA were respectively associated with 55.3% (ORs, 0.447; 95%CI, 0.378 to 0.529), 63.5% (ORs, 0.365; 95%CI, 0.285 to 0.468), and 77.1% (ORs, 0.229; 95%CI, 0.126 to 0.417) less the odds of having LTSB-lifestyle. Those performing domestic activity (DA) are greater than and equal to 19.6?MET-hours/week had 30.1% (ORs, 0.699; 95%CI, 0.576 to 0.848) less the odds. CONCLUSIONS:: Both non-sedentary occupations and DA were negatively associated with LTSB-lifestyle in these professionals. Copyright © 2016 by the American College of Occupational and Environmental Medicine

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