National Institute for Mediterranean Diet and Nutrigenomic

Reggio Calabria, Italy

National Institute for Mediterranean Diet and Nutrigenomic

Reggio Calabria, Italy
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Carbonelli M.G.,Azienda Ospedaliera San Camillo Forlanini | Di Renzo L.,University of Rome Tor Vergata | Di Renzo L.,National Institute for Mediterranean Diet and Nutrigenomic | Bigioni M.,University of Rome Tor Vergata | And 4 more authors.
Current Pharmaceutical Design | Year: 2010

Lipid peroxidation is believed to be the major biochemical alteration underling oxidant-induced cell injury in stress including numerous diseases. One of the natural molecules known to prevent or retardate oxidation is α-lipoic acid (α-LA) thus, the lipoic acid/dihydrolipoic acid (LA/DHLA) redox couple has received considerable attention. Recent studies highlighted the potential of free LA and DHLA as powerful metabolic antioxidants that are able to scavenge the reactive oxygen species and to recycle other antioxidants. Our aim was to investigate the effects of α-LA in the treatment of Italian pre-obese and obese patients. 1612 people were enrolled and 1127 of them (445 men and 682 women, 18-60 age) met criteria and were screened in the study. According to body mass index (BMI), 53% of them were obese, and 43% were pre-obese. They were treated for 4 months with 800 mg/day of α-LA. In the pre-obese group, significant reductions (p<0.001) of weight (8%, in both gender), BMI (2 points), blood pressure, and abdominal circumference (female 6 cm, male 7 cm) were observed. In the obese group, significant reductions (p<0.001) of weight (9%, in both gender), BMI (female 3 point, male 4 point), blood pressure and abdominal circumference (female 9 cm, male 11 cm) were highlighted. Our study indicated that α-LA is an ideal antioxidant candidate for the therapy of obesity related diseases. Further clinical studies should be considered to demonstrate the role and efficacy of α-LA treatment. © 2010 Bentham Science Publishers Ltd.


Di Renzo L.,University of Rome Tor Vergata | Di Renzo L.,National Institute for Mediterranean Diet and Nutrigenomic | Carbonelli M.G.,Azienda Ospedaliera San Camillo Forlanini | Bianchi A.,University of Rome Tor Vergata | And 5 more authors.
International Journal of Obesity | Year: 2012

Background: There is growing evidence that interleukin-6 (IL-6) is linked to the regulation of fat mass (FM). Our previous data define the common 174G>C IL-6 polymorphism as a marker for vulnerable individuals at risk of age-and obesity-related diseases. An association between 174G>C IL-6 polymorphism and weight loss after bariatric surgery has been demonstrated.Objective: We investigated the impact of 174G>C IL-6 polymorphism on weight loss, body composition, fluid distribution and cardiometabolic changes in obese subjects, after laparoscopic adjustable gastric banding (LAGB) surgery.Design and Outcome measures:A total of 40 obese subjects were studied at baseline and at 6 months follow-up after LAGB surgery. Cardiometabolic and genetic assessment of 174G>C IL-6 polymorphism, anthropometric, body composition and fluid distribution analysis were performed.Results:After LAGB surgery, significant reductions in weight (Δ%11.66±7.78, P<0.001), body mass index (P<0.001), total and trunk FM (kg, %) (Δ% of total FM22.22±12.15, P<0.01), bone mineral density (T-score) (P<0.001), resting metabolic rate (RMR) (P<0.01), and total body water and intracellular water (TBW, ICW) (P<0.05) were observed. At baseline, C() carriers of IL-6 polymorphism had a significantly higher RMR (P<0.05), free FM (kg), but less total and trunk FM (%), higher body cell mass (BCM), content of TBW (L) and ECW (extracellular water)/ICW ratio compared with C(+) carriers (P<0.001). After LAGB, C(+) carriers had a significantly stronger reduction of total FM (kg), but lower bone density, compared with C(+) carriers (P>0.05).Conclusions:Beyond the relationship between 174G>C IL-6 polymorphism and body composition, this study provides first evidence about the association of IL-6 variant with fluid distribution, at baseline, and FM and bone density loss in obese subjects at 6 months follow-up after LAGB surgery. LAGB was less effective if the subjects were carrying risk genotypes, C(+) carriers, for obesity, suggesting a role of genetic variations on bariatric surgery outcomes. © 2012 Macmillan Publishers Limited All rights reserved.


Di Daniele N.,University of Rome Tor Vergata | Petramala L.,University of Rome Tor Vergata | Di Renzo L.,University of Rome Tor Vergata | Di Renzo L.,National Institute for Mediterranean Diet and Nutrigenomic | And 9 more authors.
Acta Diabetologica | Year: 2013

Metabolic syndrome (MS) is a cluster of metabolic alteration associated with a higher risk of cardiovascular disease and overall mortality than the single alterations alone. The Italian Mediterranean Diet (IMD) can exert a positive effect on cardiovascular risk and related morbidity and mortality. The aim was to evaluate the benefits of dietary intervention based on a typical IMD on body composition, cardiometabolic changes and reduction in cardiovascular disease in patients with MS. Eighty White Italian subjects with MS were prescribed a balanced hypocaloric IMD. We investigated dietary habits and impact of the diet on health status, blood biochemical markers, anthropometric measurements and body composition during a 6-month follow-up period. Body composition, fat mass and distribution were assessed by Dual X-ray absorptiometry. Adherence to the IMD led to a decrease in body weight (102.59 ± 16.82 to 92.39 ± 15.94 kg, p < 0.001), body mass index (BMI) (38.57 ± 6.94 to 35.10 ± 6.76, <0.001) and waist circumference (112.23 ± 12.55 vs 92.42 ± 18.17 cm, p < 0.001). A significant loss of total body fat especially in waist region was observed. The MS was resolved in 52 % of the patients. Significant improvements in systolic and diastolic blood pressure and fasting glucose occurred. Low-density lipoprotein cholesterol was reduced from 128.74 ± 33.18 to 108.76 ± 38.61 mg/dl (p < 0.001), triglycerides from 169.81 ± 80.80 to 131.02 ± 63.88 mg/dl (p < 0.001). The present results suggest that a dietary intervention based on a typical IMD effectively promotes weight loss and reduces the growing burden of cardiovascular risk factors that typifies patients with MS. © 2012 Springer-Verlag Italia.


De Lorenzo A.,University of Rome Tor Vergata | De Lorenzo A.,National Institute for Mediterranean Diet and Nutrigenomic | Nardi A.,University of Rome Tor Vergata | Iacopino L.,University of Rome Tor Vergata | And 6 more authors.
Journal of Endocrinological Investigation | Year: 2014

Background: Obesity represents a global public health problem due to its association with cardiovascular diseases and reduced lifespan. The most widely used classification of obesity is expressed as Body Mass Index (BMI); however, this formula is an imprecise adiposity measurement that ignores several important factors involved. Body Adiposity Index (BAI) was more recently proposed as an indirect evaluation of percentage body fat (PBF). PBF is a direct measure of person's relative body fat and a better predictor of obesity-related risk diseases than BMI and BAI. Since obesity and consequent diseases are considered epidemic, new accurate formulas for epidemiological studies are of interest to the scientific community. Because direct measurement of body composition could be quite expensive, the aims of our work were to analyse the distributions of PBF by Dual X-ray absorptiometry, and the creation of new predictive equation using only anthropometric measures that could be helpful to clinicians to assess easily body fat of female patients. Methods/results: A sample of 1,031 Caucasian Italian women was recruited and BMI, BAI and PBF were evaluated. With the aim of developing a predictive model of PBF a multivariate regression model was fitted to observed data. Conclusions: The definition of universally recognized PBF by gender and age could have public health implications. In this study, we developed a new predictive PBF equation that does not require the use of medical instruments or skilled measurement techniques and that may be easily applicable to Italian women. © 2014 Italian Society of Endocrinology (SIE).


Di Renzo L.,University of Rome Tor Vergata | Sarlo F.,University of Rome Tor Vergata | Petramala L.,University of Rome Tor Vergata | Iacopino L.,University of Rome Tor Vergata | And 4 more authors.
Disease Markers | Year: 2013

Background and Aim. Normal weight obese (NWO) syndrome is characterized by normal body mass index (BMI), but high amount of fat mass and reduced lean mass. We evaluated allelic frequency of the G/A -308 TNF-α polymorphism and prevalence of sarcopenia in NWO. Methods. We enrolled 120 Italian healthy women, distinguished into 3 groups: normal weight (NW); NWO, and preobese-obese (PreOB/OB) and evaluated anthropometric parameters, body composition by dual X-ray absorptiometry, blood tests, and genotyping of G/A -308 TNF-α polymorphism. Results. We found a positive association between sarcopenic obesity and -308 TNF-α polymorphism. All obese women were sarcopenic and were no carrier of mutation (G/G). Among all G/G, NWO showed significant differences in lean mass and total body lean mass (TBLean) with respect to NW and PreOB/OB (P < 0.001). Regarding appendicular skeletal muscle mass index values, 4.21% of NW were sarcopenic (50% G/G and 50% G/A); the same percentage was observed in NWO subjects (100% G/G). Moreover, 2.10% of PreOB/OB were sarcopenic and all were G/G. Conclusion. Our study suggests that TNF-α polymorphism contributes to sarcopenic obesity susceptibility, in association with body composition. This is the first study that shows the importance of TNF-α polymorphism to determine TBLean variation in NWO syndrome. © 2013 L. Di Renzo et al.


Di Renzo L.,University of Rome Tor Vergata | Di Renzo L.,National Institute for Mediterranean Diet and Nutrigenomic | Galvano F.,University of Catania | Orlandi C.,University of Rome Tor Vergata | And 6 more authors.
Obesity | Year: 2010

The normal-weight obese (NWO) syndrome was identified in women whose body weight (BW) and BMI are normal but whose fat mass (FM) is 30%. In these subjects, an early inflammatory status has been demonstrated. The aim was to verify whether oxidative stress occurs in NWO. Sixty age-matched white Italian women were studied and subdivided as follows: 20 normal-weight individuals (NW) (BMI 25kg/m2; FM% 30%); 20 NWO (BMI <25kg/m2; FM% 30%); 20 preobese-obese (OB) (BMI <25kg/m 2; FM% 30%). Anthropometric, body composition (by dual-energy X-ray absorptiometry) variables, plasma levels of some cytokines, reduced glutathione (GSH), lipid hydroperoxide (LOOH), nitric oxide (NO) metabolites (NO 2 /NO 3 ), antioxidant nonproteic capacity (ANPC) were measured and compared between groups. Glucose and lipid metabolism parameters were assessed. GSH and NO2 /NO3- levels resulted lower in OB and NWO compared to NW (P 0.01). LOOH levels resulted higher in OB and NWO (P< 0.01). ANPC in NWO was lower than NW but higher with respect to OB (P< 0.01). Correlation analysis revealed strong associations between GSH levels and BW, BMI, FM% (R = 0.45, at least P 0.05); waist circumference (W) (R = 0.33, P 0.05); FFM% (R = 0.45, P< 0.01); IL-1α, IL-6, IL-10, IL-15 (R = 0.39, 0.33, 0.36 0.34, respectively, P 0.05); triglycerides (R = 0.416, P 0.05). LOOH levels were negatively related to FFM% (R = 0.413, P 0.05) and positively to FM%, IL-15, TNF-α, insulin, total cholesterol, low-density lipoprotein cholesterol, and triglycerides (R = 0.408, R = 0.502, R = 0.341, R = 0.412, R = 0.4036, R = 0.405, R = 0.405, respectively, P <0.05). The study clearly indicates that NWO, besides being in early inflammatory status, are contextually exposed to an oxidative stress related to metabolic abnormalities occurring in obesity. © 2010 The Obesity Society.


De Lorenzo A.,University of Rome Tor Vergata | De Lorenzo A.,National Institute for Mediterranean Diet and Nutrigenomic | Noce A.,University of Rome Tor Vergata | Bigioni M.,University of Rome Tor Vergata | And 6 more authors.
Current Pharmaceutical Design | Year: 2010

Objective: The aim of this study was to verify the effects of Italian Mediterranean Diet (IMD), consisting of organic versus conventional foods, on body composition, and biochemical parameters in a healthy individuals and in Chronic Kidney Disease (CKD) patients, in order to decrease cardiovascular diseases (CVD) risk factor and the progression of renal diseases. Design: After providing a written fully informed consent to the study, 150 Caucasian Italian men were recruited: 100 healthy male individuals (mean age 44,66±13,98 years; range 30-65 years) and 50 male CKD patients (mean age 46,25±5,97 years; range 42-54 years). These patients were affected by stage 2 and 3 of Chronic Renal Failure according to the K-DOQI 2003. Usual dietary intake and physical activity, during the previous 12 months were estimated by a semiquantitative food-frequency questionnaire. The following were measured at baseline and after consumption of conventional/organic 14 days IMD: Body mass index (BMI), Body composition, by Dual-X absorptiometry (DXA) scanner, total plasma homocysteine (tHcy), serum phosphorus, glycemia concentrations, lipid profile, and microalbuminuria. Results: A significant reduction of total homocysteine (tHcy) and phosphorus blood values were observed in the studied subjects. Body composition analysis by DXA highlighted high significant differences between conventional (T0) and organic diet (T 1) for fat mass parameter, expressed as kilograms and as percentage (p<0.001). Improvement of lean body mass was observed in CDK patients (p=0.004). Conclusions: Our study clearly demonstrates that the Italian Mediterranean Organic Diet (IMOD), according to the "Nicotera diet", was able to reduce tHcy, phosphorus, microalbuminuria levels and CVD risk in healthy individuals and in CDK patients. © 2010 Bentham Science Publishers Ltd.


De Lorenzo A.,University of Rome Tor Vergata | De Lorenzo A.,National Institute for Mediterranean Diet and Nutrigenomic | Bianchi A.,University of Rome Tor Vergata | Maroni P.,Capgemini Italia S.p.a. | And 5 more authors.
International Journal of Cardiology | Year: 2013

Background and aim: There is increasing evidence suggesting that WHO body mass index (BMI) cut-off values are outdated and should not be applied to different population. To overcome misclassifications, direct measurements of percentage body fat (PBF) would be a better tool for preobesity and obesity diagnosis. The aim of this study was to analyze the body composition in a adult population in Centre-South of Italy, by age and gender, and to verify the accordance between BMI and PBF cut-off points for health status classification. Methods: The total subject pool cover a total of 4408 participants adults. A completed screening of anthropometry and body composition by Dual X-ray Absorptiometry, (DXA) was assessed on 3.258 subjects. Results: Distributions and quantitative reliable estimates of PBF, total body fat and lean, according to gender and age are provided. The prevalence of "at risk" subjects (preobese and obese) was 69% and 85%, for men and women respectively, according to PBF cut-off points. The agreement of BMI and PBF categories resulted low for the total and male population, even scarce for female population (all P ≤ 0.001). The false negative classification of BMI was stronger for women than men and for younger than older subjects. Conclusions: Screening for adiposity in subjects with a normal BMI could better identify those at higher risk for cardiometabolic disturbances and cardiovascular mortality. The herein used cut-offs points of PBF, by age and gender, may provide a useful reference in clinical settings and public health services, in particular for the Italian Caucasian population. © 2011 Elsevier Ireland Ltd.


Renzo L.D.,University of Rome Tor Vergata | Renzo L.D.,National Institute for Mediterranean Diet and Nutrigenomic | Rizzo M.,University of Rome Tor Vergata | Sarlo F.,University of Rome Tor Vergata | And 6 more authors.
European Review for Medical and Pharmacological Sciences | Year: 2013

Background: Normal weight obese (NWO) syndrome is defined as an excessive body fat associated with a normal body mass index and characterized by a higher risk for cardiovascular morbidity and mortality. Recent studies have demonstrated that dark chocolate (DC) has beneficial effects in the prevention of cardiovascular diseases (CVD) due to its anti-inflammatory and antioxidant properties. AIM: The aim of the present study was to investigate the effects of DC consumption on lipid profile, inflammatory markers, biochemical parameters, and blood pressure, in NWO women. Materials and methods: 15 women affected by NWO syndrome, aged 20-40 years, were included in the study. After a DC-free washout period, subjects received DC (100 g/die) containing 70% cocoa for 7-days. Body composition by Dual energy-X-ray absorptiometry (DXA) was performed at baseline. Blood pressure, anthropometric measurements, biochemical parameters and plasma levels of some cytokines were measured before and after DC consumption. Results: After DC consumption, we observed a significant increase in the HDL cholesterol level (Delta% = +10.41) 13,53; p . 0.05), a significant decrease of total cholesterol/HDL cholesterol ratio (Delta %= .11.45≤ 7.03; p . 0.05), LDL/HDL cholesterol ratio (Delta % = .11.70≤ 8.91; p . 0.05), and interleukin-1 receptor antagonist (IL- 1Ra) (Delta % = .32.99≤ 3.84; p . 0.05). In addition, a reduction in abdomen circumference was observed. We also found a positive correlation between changes in atherogenic indices, and IL- 1Ra, abdomen reduction. Conclusions: Our findings suggest that regular consumption of DC could be useful in maintaining a good atherogenic profile, due to the favourable effects on HDL cholesterol, lipoprotein ratios and inflammation markers.


Di Renzo L.,University of Rome Tor Vergata | Di Renzo L.,National Institute for Mediterranean Diet and Nutrigenomic | Bianchi A.,University of Rome Tor Vergata | Saraceno R.,University of Rome Tor Vergata | And 6 more authors.
Pharmacogenetics and Genomics | Year: 2012

Background: Although TNF-α blockade is a very effective therapy for psoriasis, not all patients achieve a favorable outcome. The association between IL-6 and psoriasis has been investigated but no papers have focused on the pharmacogenetics of IL-6. OBJECTIVE: To examine whether the G or the C allele, at position-174 in the promoter of IL-6, influences the relationships between body weight, body composition, and therapeutic response to TNF-α blockers in psoriasis. Methods: Sixty patients with psoriasis were studied, at baseline and 6-month follow-up after therapy. Assessment of the-174G/C IL-6 polymorphism, Psoriasis Area and Severity Index and Disease Activity Score-28 scores, body weight (kg), BMI, body composition by Dual-energy X-ray absorptiometry, and systemic inflammation was performed. Results: Relevant body composition changes occurred after therapy. Normal weight participants showed a greater increase in fat mass than lean mass, compared with obese participants. According to their genotypes, C(+) carriers showed a greater increase in lean mass and fat mass, at the abdominal region, with respect to C(-) carriers. C(+) carriers outweighed C(-) carriers in the group of treatment responders. A higher number of responders were present among normal weight participants, with respect to obese participants. Obesity and the-174G/C IL-6 polymorphism predicted poor response to TNF-α blockers [odds ratio for C(-) carriers, obese: 2.00 (confidence interval: 1.19-3.38; P≤0.05)]. Conclusion: Our data show that the G allele of the-174G/C IL-6 polymorphism and obesity can be considered as risk factors for the prognosis and management of psoriasis. This is the first study to suggest the-174G/C IL-6 polymorphism as a novel genetic marker of responsiveness to TNF-α blockers in psoriasis. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

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