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Hantson P.,Catholic University of Louvain | Hantson P.,Cliniques Universitaires Saint Luc | Di Fazio V.,National Institute for Criminology and Criminalistics | Del Mar Ramirez Fernandez M.,National Institute for Criminology and Criminalistics | And 3 more authors.
Journal of Medical Toxicology | Year: 2014

Introduction Toxic leukoencephalopathy is a possible but rare complication of chronic cocaine abuse. The role of adulterants, mainly levamisole, is still debated. Case Report We describe an atypical case of fatal leukoencephalopathy mimicking Susac syndrome in a 22-year-old man who was chronically abusing cannabis and cocaine. Exposure to levamisole as adulterant to cocaine was proven by hair analysis. Despite cessation of exposure to cocaine and aggressive immunosuppressive therapy, the patient remained in a minimally conscious state until death. Discussion Susac syndrome is a rare entity, and its etiology is not yet fully elucidated. The toxic etiologies have been poorly investigated to date. Further observations are required to determine if cocaine and/or adulterants might play a significant role. © 2014 American College of Medical Toxicology.

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