Binato R.,National Cancer Institute INCA |
Binato R.,National Institute for Cancer Control INCT |
Meyer C.,Goethe University Frankfurt |
Macedo-Silva M.L.,National Cancer Institute INCA |
And 11 more authors.
Cancer Letters | Year: 2013
Translocations involving MLL gene are common among children with acute leukemias. Most importantly, the presence of a given MLL fusion partner dictates the outcome of patients. Patients with complex MLL rearrangements, e.g. three-way translocations could be related to a poor clinical outcome. For this purpose, we characterize 5 childhood patients with three-way translocations involving MLL gene. By LDI-PCR we identified 15 out of 17 fusion alleles and determined the localization of these breakpoints. In all cases at least one functional MLL fusion allele was present. In addition, patients displayed a remaining 3'-MLL allele that allow in principle the expression of the MLL* protein variant. © 2013 Elsevier Ireland Ltd.