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Budapest, Hungary

Chunhavuthiyanon M.,National Innovation Office | Intarakumnerd P.,National Graduate Institute for Policy Studies
International Journal of Technology Management and Sustainable Development | Year: 2014

Unlike previous snapshot studies, this research traces 'historical learning events' to enable us to examine the evolution of roles and underpinning capabilities of intermediaries in an innovation system. By following this approach, the rationale, obstacles and lessons learned of intermediaries in performing their roles and building up required capabilities can be vividly illustrated. The National Food Institute (NFI) of Thailand was selected as the case study. As an intermediary organization, NFI has enhanced its capabilities step by step in analysing and disseminating information, training, testing policy development and consultancies through major 'learning events' that provide NFI with learning opportunities. As a result, over time it can perform its intermediary roles better by reducing 'systemic failures' in the Thai food industry's sectoral innovation system. Recently, however, due to the lack of an official mandate, continuous government budgetary support and organizational lock-in problems, NFI's role has not evolved with the changes in strategies and capability needs of Thai food exporters as these firms change from OEM to OBM manufacturers. © 2014 Intellect Ltd Article. Source

Saisirirat P.,National Metal and Materials Technology Center | Chollacoop N.,National Metal and Materials Technology Center | Tongroon M.,National Metal and Materials Technology Center | Laoonual Y.,King Mongkuts University of Technology Thonburi | Pongthanaisawan J.,National Innovation Office
Energy Procedia | Year: 2013

In this study, the benefits and trade-off for penetration of electric vehicle (EV) technology in Thai road transportation were analyzed by using offend-use energy demand model. Two vehicle types (motorcycle and passenger car) were considered for possible EV penetration as partial EV, which are hybrid EV (HEV) and plug-in hybrid EV (PEV) and full EV, which is battery EV (BEV). The assumption for EV penetration was derived from Thai government policy target and available technology perspective into four different scenarios, e.g. Business As Usual (BAU), electric motorcycle (eMC), passenger car EV (PcEV) and the extremely case of combined EV penetration in both motorcycle and passenger car. The energy demand model for road transportation from our previous works was constructed using © 2013 The Authors. Published by Elsevier B.V. Source

Rawat Y.S.,National Innovation Office | Vishvakarma S.C.R.,Gb Pant Institute Of Himalayan Environment And Development
Proceedings of the National Academy of Sciences India Section B - Biological Sciences | Year: 2011

Agriculture and animal husbandry are prime occupations of rural people of the Kullu and Lahaul valleys. Livestock is an integral part of the livelihood, which rely mostly on fodder extracted from forests, grasslands, agriculture and agroforestry. In north-western Himalaya, farmers follow an indigenous agroforestry system by maintaining naturally regenerating tree species, particularly on the edges of terraced agriculture fields without any significant input of manpower. The authors examined this agroforestry system in five villages of the Kullu and Lahaul valleys. The diversity of fodder species decreased with increasing elevation. The total number of fodder species was 67 comprising 43% trees, 27% small trees and 30% shrubs. The per tree fodder production was maximum at intermediate elevation. The utilization pattern of the fodder species varied along the elevation; higher number of species occurred in lower altitudes as compared to higher altitudes. Majority of the fodder species are used as multipurpose species which contribute to socio-economics of the region. The diversity, distribution and utilization pattern of the fodder species is important for their prioritization in their conservation and management. Source

Grumm R.H.,National Innovation Office
Bulletin of the American Meteorological Society | Year: 2011

The large-scale conditions associated with the eastern European and Russian heat wave of July-August 2010, leading to above-normal warmth, are presented. The 500-hPa heights, 700-hPa temperatures, and other standard level fields were derived from the National Centers for Environmental Prediction Global Forecast System (NCEP GFS) 00-hour forecasts. The key features associated with the protracted heat wave included an abnormally strong ridge. The weak 250-hPa winds in ridge and the weak 700-hPa u-winds suggest that a persistent blocking episode was present. Over northern Russia, the ridge increased the gradient, and the 250-hPa winds reached as high as +5 SDs above normal at times over northern Russia and were +3 SDs above normal at 1200 UTC 28 July 2010. All the forecasts suggested +2 to +3 SD 500-hPa height anomalies over west-central Russia. Source

Hoffman E.P.,Center for Genetic Medicine Research | Hoffman E.P.,George Washington University | Connor E.M.,National Innovation Office | Connor E.M.,George Washington University
Discovery Medicine | Year: 2013

Duchenne muscular dystrophy is a relatively common 'rare disorder,' with an incidence of about 1/5,000 males worldwide. The responsible gene and deficient protein (dystrophin) were identified in 1987, an early success of human molecular genetics and emerging genome projects. A rational approach to therapeutics is to replace dystrophin in patient muscle, thus addressing the primary biochemical defect. Fast forward 25 years, and two phase 2b/3 trials have been carried out with agents designed to induce de novo dystrophin production in DMD patient's muscle; ataluren (stop codon read through) with 174 patients, and drisapersen (exon skipping) with 186 patients. Both used a six minute walk test as the primary outcome measure. Neither drisapersen nor high dose ataluren showed any significant improvement in this outcome, whereas low dose ataluren is reported to show some possible improvement. Experience with ataluren and drisapersen has been disappointing and this is a good time to ask: What can we learn from these programs and how can this inform further drug development in DMD? At the times these two trials were started, there was a lack of existing data and infrastructure regarding both clinical and biochemical outcome measures. The recent publications of more extensive natural history data in multiple DMD cohorts, and ongoing efforts to define reliable and sensitive dystrophin assays are important. If the drisapersen and ataluren programs were instead begun today, new progress in biochemical and clinical endpoints may have triggered a re-design, with better de-risking in phase 2 studies prior to resource-intensive phase 3 trials. © Discovery Medicine. Source

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