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Inoue T.,Okayama University of Science | Sugiyama H.,Okayama University of Science | Hiki Y.,Fujita Health University Hospital | Takiue K.,Okayama University of Science | And 9 more authors.
Clinical Immunology | Year: 2010

Aberrant O-glycosylation of serum and tonsillar IgA1 is one of the main pathogeneses of IgA nephropathy (IgAN). However, the synthesis of underglycosylated IgA1 in tonsils has not yet been characterized. This study examined tonsillar B lymphocytes of IgAN (n= 34) using tonsils derived from patients with chronic tonsillitis (n= 24) and sleep apnea syndrome (n= 14) as a control. Gene expression of β1,3-galactosyltransferase (β3GalT), and the core 1 β3GalT-specific molecular chaperone, Cosmc, UDP-N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyl-transferase 2, were significantly decreased in tonsillar CD19-positive B lymphocytes from IgAN patients compared to control tonsillar tissues as determined by real-time RT-PCR. Tonsillar B cell β3GalT gene expression significantly correlated with estimated GFR and negatively correlated with proteinuria and histological injury score. Western blotting showed the protein expression of β3GalT in the tonsils to significantly decrease in IgAN in comparison to the controls. These data suggest the downregulation of β3GalT in tonsillar B lymphocytes to be closely associated with the clinical characteristics of IgAN. © 2010 Elsevier Inc. Source

Tokumo M.,National Hospital Organization Minami Okayama Medical Center | Ohashi R.,Kagawa Prefectural Central Hospital | Jida M.,Kagawa Prefectural Central Hospital | Kubo T.,Kagawa Prefectural Central Hospital | And 6 more authors.
Japanese Journal of Gastroenterological Surgery | Year: 2013

A 78-year-old woman consulted the Department of Internal Medicine about dysphagia in December 2004. Upper gastrointestinal X-ray examination showed a 3-cm long stricture of the middle thoracic esophagus. Gastrointestinal fiberscopy showed a stricture of the thoracic esophagus at approximately 28 to 30 cm from the incisor, but there was no tumorous appearance on the membrane. For this stricture of the esophagus of unknown origin, balloon dilation was performed at first. Her symptoms slightly improved after dilation, but did not disappear, therefore balloon dilation was repeated 5 times, however, her symptoms did not completely disappear. An esophageal stent insertion was performed in August 2006. Shortly after stent insertion, stent obstruction caused by food waste and continuous precordialgia or epigastralgia occurred. She then consulted the surgery department and in September 2006, underwent an operation under general anesthesia. Pathological examination of the resected specimen showed epithelioid hemangioendothelioma corresponding to the site of stricture. We conclude that this rare tumor was caused by esophageal stenosis. © 2013 The Japanese Society of Gastroenterological Surgery. Source

Ohta K.,Teikyo University | Yamaguchi M.,Teikyo University | Akiyama K.,National Hospital Organization Sagamihara National Hospital | Adachi M.,Showa University | And 5 more authors.
Allergology International | Year: 2011

Adult bronchial asthma (hereinafter, asthma) is characterized by chronic airway inflammation, reversible airway narrowing, and airway hyperresponsiveness. Long-standing asthma induces airway remodeling to cause an intractable asthma. The number of patients with asthma has increased, while the number of patients who die from asthma has decreased (1.7 per 100,000 patients in 2009). The aim of asthma treatment is to enable patients with asthma to lead a healthy life without any symptoms. A partnership between physicians and patients is indispensable for appropriate treatment. Long-term management with agents and elimination of causes and risk factors are fundamental to asthma treatment. Four steps in pharmacotherapy differentiate mild to intensive treatments; each step includes an appropriate daily dose of an inhaled corticosteroid (ICS), varying from low to high doses. Long-acting β2 agonists (LABA), leukotriene receptor antagonists, and theophylline sustainedrelease preparation are recommended as concomitant drugs, while anti-IgE antibody therapy is a new choice for the most severe and persistent asthma. Inhaled β2 agonists, aminophylline, corticosteroids, adrenaline, oxygen therapy, etc., are used as needed against acute exacerbations. Allergic rhinitis, chronic obstructive pulmonary disease (COPD), aspirin induced asthma, pregnancy, and cough variant asthma are also important factors that need to be considered. ©2011 Japanese Society of Allergology. Source

Shimizu T.,Tokyo Metropolitan Neurological Hospital | Nagaoka U.,Tokyo Metropolitan Neurological Hospital | Nakayama Y.,Tokyo Metropolitan Institute of Medical Science | Kawata A.,Tokyo Metropolitan Neurological Hospital | And 16 more authors.
Amyotrophic Lateral Sclerosis | Year: 2012

Malnutrition in the early stage has been reported as an independent predictor of survival in amyotrophic lateral sclerosis (ALS). We analyzed retrospectively the effect of variation of body mass index (BMI) on survival in ALS patients. In total, 77 consecutive ALS patients were enrolled from nine hospitals in Japan. Reduction rate of BMI was calculated from BMI before the disease onset and at the time of the first visit to each hospital. We analyzed the correlation between BMI reduction rate and total disease duration. Results showed that the median BMI reduction rate was 2.5 per year (interquartile range 1.33.8). The BMI reduction rate was significantly correlated with survival length (p <0.0001). There was also a significant difference in survival between ALS patients with a BMI reduction rate ≥ and < 2.5 (Kaplan-Meier survival analysis and the log-rank test, p < 0.0001; hazard ratio by the Cox model, 2.9816). In conclusion, faster reduction of BMI at the initial stage before the first visit to hospital predicts shorter survival length also in Japanese ALS patients. © 2012 Informa Healthcare. Source

Saitou Y.,National Hospital Organization Higashi Nagoya National Hospital | Sakai K.,National Hospital Organization Minami Okayama Medical Center | Konagaya M.,National Hospital Organization Suzuka Hospital
Japanese Journal of Geriatrics | Year: 2016

Aim: Subacute myelo-optico-neuropathy (SMON) is a known adverse effect of clioquinol use; however, clioquinol dissolves beta- amyloid aggregation in Alzheimer’s disease (AD). Therefore, we investigated the prevalence of dementia in SMON patients and whether past clioquinol use affected the current incidence of AD. Methods: We included 647 SMON patients (195 men, 452 women; mean age 77.9 years) who had undergone medical checkups including the mini-mental state examination (MMSE) in 2012. Of them, 105 patients scored £23 on the MMSE assessment. The presence/absence of dementia and disease backgrounds were obtained by a questionnaire. Then, using the medical checkup database, the correlation between the degree of severity when signs of SMON were at their worst and the concurrent presence or absence of AD at present was analyzed. Results: In patients ³65 years of age, the estimated prevalence of dementia was approximately 10.9% (95% confidence interval: 7.9%-13.8%). The concurrent presence of AD at present was not correlated with the past degree of SMON severity when the SMON signs were at their worst. Conclusions: The 10.9% prevalence of dementia in SMON patients was lower than a previously reported 15% prevalence found in the general population. According to these results, we cannot draw a definitive conclusion regarding the preventive effect of clioquinol on AD. Additionally, the lack of association between the onset of AD and past severity of SMON precludes definitive conclusions on the relationship between concurrent presence of AD and past clioquinol use. © 2016, Japan Geriatrics Society. All rights reserved. Source

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