National Evidence Based Health Care Collaborating Agency

Seoul, South Korea

National Evidence Based Health Care Collaborating Agency

Seoul, South Korea
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Mo J.-A.,National Evidence Based Health Care Collaborating Agency | Mo J.-A.,Inha University | Lim J.-H.,National Evidence Based Health Care Collaborating Agency | Sul A.-R.,National Evidence Based Health Care Collaborating Agency | And 3 more authors.
PLoS ONE | Year: 2015

Objectives: The purpose of this study was to carry out systematic review of the literature and metaanalysis to evaluate the diagnostic utility of cerebrospinal fluid (CSF) levels of the 42 amino acid form of amyloid-beta (Aβ1-42) as a biomarker for differentiating Alzheimer's disease (AD) from non-AD dementia. Methods: Design. Systematic literature review was used to evaluate the effectiveness of the Aβ for the diagnosis of AD. The Scottish Intercollegiate Guidelines Network (SIGN) tool was used to evaluate independently the quality of the studies. Data sources. The literature review covered from January 1, 2004, to October 22, 2013, and searched eight domestic databases including Korea Med and international databases including Ovid-MEDLINE, EMBASE, and Cochrane Library. Data Extraction and Synthesis. Primary criteria for inclusion were valid studies on (i) patients with mild cognitive impairment with confirmed or suspected AD and non-AD dementia, and (ii) assessment of Aβ1-42 levels using appropriate comparative tests. Results: A total of 17 diagnostic evaluation studies were identified in which levels of CSF Aβ1-42 were assessed. Meta-analysis was performed on 11 robust studies that compared confirmed AD (n = 2211) with healthy individuals (n = 1030), 10 studies that compared AD with non-AD dementias (n = 627), and 5 studies that compared amnestic mild cognitive impairment (n = 1133) with non-amnestic type subjects (n = 1276). Overall, the CSF Aβ1-42 levels were reduced in AD compared to controls or non-AD dementia. The effectiveness of test was evaluated for diagnostic accuracy (pooled sensitivity, 0.80 (95% CI 0.78-0.82); pooled specificity, 0.76 (95% CI 0.74-0.78). Conclusions: Reduced CSF Aβ1-42 levels are of potential utility in the differential diagnosis of AD versus non-AD dementias and controls. Diagnostic accuracy was high in AD versus healthy controls. However, differential diagnosis for MCI or non-AD might be evaluated by other biomarkers. © 2015 Mo et al.


Park S.,Kyung Hee University | Romer D.,University of Pennsylvania | Lim S.,National Evidence Based Health Care Collaborating Agency
Journal of Addictions Nursing | Year: 2013

The association between smoking and depression has been well stated in the literature. However, themechanisms underlying this phenomenon are still unclear. Recent research using an animal model suggests that even low-level nicotine exposure during adolescence has long-lasting effects on the development of depression. This study aims to examine the association between smoking initiation and depression analyzing secondary data. A sample that is representative of the South Korean adult population was selected from the Fourth KoreaNationalHealth and Nutrition Examination Survey collected from 2007 to 2009 (N = 18,406). Regardless of life stage of smoking initiation, smokers had greater risk for depression in adulthood than nonsmokers after adjusting for demographics and other depression-related covariates. The results indicate that, with regard to risk for depression, it is important to prevent smoking initiation at any life stage. Successful implementation of smoking prevention strategies should lead to enhanced mental (i.e., reduced risk for depression) as well as physical health of adults in the long run. Copyright © 2013 International Nurses Society on Addictions.


PubMed | National Evidence based Health Care Collaborating Agency and Inha University
Type: Journal Article | Journal: Journal of Korean Academy of Nursing | Year: 2016

This study was conducted to synthesis the results of research on relationships of cognitive impairment with multi-dimensional correlates of rheumatic disease through a systematic literature review and meta-analysis.For the study purpose, 23 studies were selected through a systematic process of searching the literature.The study results showed that among general characteristics, age and education were the variables having a significant relationship with cognitive impairment. Among health risk factors, obesity appeared to have a significant positive relationship with cognitive impairment. For past history, diabetes and hypertension were shown to have a significant positive relationship with cognitive impairment. It was noted also that aPL, one of the physiological factor, had significant association with cognitive impairment. None of the medication related factors had a significant relationship with cognitive impairment. Results showed that among disease related factors, disease activity had the highest relationship with cognitive impairment. Depression, among psychological factors, was the only variable having a significant relationship with cognitive impairment.The findings indicate that the variables strongly impacting on cognitive impairment in rheumatic disease are depression and disease activity.


PubMed | National Evidence based Health Care Collaborating Agency and Kyung Hee University
Type: Journal Article | Journal: European journal of oncology nursing : the official journal of European Oncology Nursing Society | Year: 2014

Repeated participation in fecal occult blood testing (FOBT) is one of the major factors affecting the long-term success of population-based colorectal cancer screening programs. The aim of this study is to explore strong factors linked to repeated participation in FOBT in the prior decade (2002-2011) among adults using the Health Belief Model (HBM) after controlling for other covariates.Data were obtained from South Korean adults, aged 50 years and over, who visited a national health screening center within a magnet hospital (N = 237). A pilot test was conducted to investigate the internal consistency of the HBM instruments and the clarity of survey questions. Sample characteristics and rates of adherence to FOBT screening were examined using means and frequencies. Important factors associated with adherence to FOBT were examined using multivariate logistic regression analysis.About 44% of the respondents were adherent to FOBT screening over the prior decade. Four out of the six HBM-driven factors (perceived susceptibility, severity, and barriers, and health motivation) were statistically significant. Those with greater levels of susceptibility and health motivation and lower levels of severity and barriers were more likely to adhere to FOBT.Health professionals should focus more on the four modifiable HBM-related factors to encourage adults to adhere to FOBT. Intervention programs, which lower perceived severity and barriers and increase susceptibility and health motivation, should be developed and implemented.


PubMed | National Evidence Based Health Care Collaborating Agency, Inha University, Chung - Ang University and Hanyang University
Type: Journal Article | Journal: PloS one | Year: 2015

The purpose of this study was to carry out systematic review of the literature and meta-analysis to evaluate the diagnostic utility of cerebrospinal fluid (CSF) levels of the 42 amino acid form of amyloid-beta (A1-42) as a biomarker for differentiating Alzheimers disease (AD) from non-AD dementia.Design. Systematic literature review was used to evaluate the effectiveness of the A for the diagnosis of AD. The Scottish Intercollegiate Guidelines Network (SIGN) tool was used to evaluate independently the quality of the studies. Data sources. The literature review covered from January 1, 2004, to October 22, 2013, and searched eight domestic databases including Korea Med and international databases including Ovid-MEDLINE, EMBASE, and Cochrane Library. Data Extraction and Synthesis. Primary criteria for inclusion were valid studies on (i) patients with mild cognitive impairment with confirmed or suspected AD and non-AD dementia, and (ii) assessment of A1-42 levels using appropriate comparative tests.A total of 17 diagnostic evaluation studies were identified in which levels of CSF A1-42 were assessed. Meta-analysis was performed on 11 robust studies that compared confirmed AD (n = 2211) with healthy individuals (n = 1030), 10 studies that compared AD with non-AD dementias (n = 627), and 5 studies that compared amnestic mild cognitive impairment (n = 1133) with non-amnestic type subjects (n = 1276). Overall, the CSF A1-42 levels were reduced in AD compared to controls or non-AD dementia. The effectiveness of test was evaluated for diagnostic accuracy (pooled sensitivity, 0.80 (95% CI 0.78-0.82); pooled specificity, 0.76 (95% CI 0.74-0.78).Reduced CSF A1-42 levels are of potential utility in the differential diagnosis of AD versus non-AD dementias and controls. Diagnostic accuracy was high in AD versus healthy controls. However, differential diagnosis for MCI or non-AD might be evaluated by other biomarkers.

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