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Wang J.-M.,South China University of Technology | Wang J.-M.,National Engineering Research Center for Tissue Regeneration and Reconstruction | Ren L.,South China University of Technology | Ren L.,National Engineering Research Center for Tissue Regeneration and Reconstruction | And 10 more authors.
Gongneng Cailiao/Journal of Functional Materials | Year: 2012

Diffusion properties are key characteristics of cornea repairing materials. The EDC-crosslinking blend membranes were made with different ratio between chitosan and collagen. Diffusion properties of the blend membranes to oxygen, glucose, tryptophan and sodium chloride were determined. Results showed that permeability of the blend membranes were increased with the increase of ratio of collagen, and decreased with increasing amount of crosslinking agent. Comparison of the results indicated that diffusion properties of the membranes were mainly affected by the equilibrium water content.


Zhu Y.-J.,South China University of Technology | Zhu Y.-J.,National Engineering Research Center for Tissue Regeneration and Reconstruction | Ren L.,South China University of Technology | Ren L.,National Engineering Research Center for Tissue Regeneration and Reconstruction | And 5 more authors.
Gongneng Cailiao/Journal of Functional Materials | Year: 2013

In this work, regenerated bacterial cellulose (RBC) membrane was prepared by LiCl/DMAc, and influence of the concentration of bacterial cellulose solution on crystallinity, equilibrium water content, light transmittance and the diffusion of nutrients (sodium chloride, glucose sugar, tryptophan) of RBC membrane were studied. The experimental results showed that, with the concentration of bacterial cellulose solution increasing, the degree of crystallinity of regenerated membrane slightly decreased; equilibrium water content increased slightly and light transmittance of dry films changed little, but that of wet films changed obviously; the diffusion coefficient to nutrients hardly changed with the BC solution concentration, and that to glucose sugar and tryptophan were approximately 1.0×10-6 cm2/s, and the sodium chloride permeability coefficient was about 2.5×10-6 cm2/s. This work indicated that RBC membrane was promising biomaterial for corneal lamellar transplantation application.


Qiu F.,South China University of Technology | Qiu F.,National Engineering Research Center for Tissue Regeneration and Reconstruction | Ren L.,South China University of Technology | Ren L.,National Engineering Research Center for Tissue Regeneration and Reconstruction | And 10 more authors.
Huagong Xuebao/CIESC Journal | Year: 2012

The glass transition behavior of chitosan was studied through molecular dynamics (MD)simulation with the range of temperatures from 343 K to 543 K, and the glass transition temperature T g of chitosan was obtained. The molecular mechanics force field used in this study was COMPASS(condensed-phase optimized molecular potentials for atomistic simulation studies)which has been validated for chitosan in some previous communications. Under the COMPASS force field and in the NPT ensemble, the specific volumes, radii of gyration and energies of chitosan at different temperatures were calculated. The results showed that the specific volume, radius of gyration and internal energy of chitosan regularly changed along with the change of temperature, and the transition began at the T g point. The calculated T g, especially the value obtained from the slop transition of the radius of gyration vs temperature curve, was in good agreement with the experimental results. Therefore, the radius of gyration has great influence on glass transition, and the MD simulation method is a useful tool to predict the glass transition temperature of polymer. © 2012 All Rights Reserved.

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