National Engineering Research Center for Miniaturized Detection Systems Xian

Fengcheng, China

National Engineering Research Center for Miniaturized Detection Systems Xian

Fengcheng, China
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Gao Q.,Northwest University, China | Xing Y.,Yulin University | Peng M.,Northwest University, China | Liu Y.,Northwest University, China | And 6 more authors.
Chinese Journal of Chemistry | Year: 2017

Enhancement of Fe3O4/Au nanoparticles (Fe3O4/Au NPs) catalyst was observed in the oxidative degradation of methyl orange by employing H2O2 as oxidant. To evaluate the catalytic activity of Fe3O4/Au nanoparticles, different degradation conditions were investigated such as the amounts of catalyst, H2O2 concentration and pH value. Based on our data, methyl orange was degraded completely in a short time. The enhanced catalytic activity and increased oxidation rate constant may be ascribed to synergistic catalyst-activated decomposition of H2O2 to •OH radical, which was one of the strong oxidizing species. Besides, Fe3O4/Au nanoparticles have exhibited satisfying recycle performance for potential industrial application. © 2017 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


PubMed | National Engineering Research Center for Miniaturized Detection Systems Xian, Second Peoples Hospital Kunming 650021, Minzu University of China and Life Detection Systems
Type: Journal Article | Journal: International journal of clinical and experimental pathology | Year: 2016

It is well-established that differences among ethnic groups in drug responses are primarily due to the genetic diversity of pharmacogenes. A number of genes or variants that play a crucial role in drug responses have been designated Very Important Pharmacogenes (VIP) by the PharmGKB database. Clarifying the polymorphic distribution of VIPs in different ethnic groups will aid in personalized medicine for specific populations.We sequenced 85 VIP variants in the Lhoba population based on the PharmGKB database. The polymorphic distribution of the 85 VIP variants in 100 Lhoba subjects was determined and compared with that of 11 major HapMap populations, including ASW, CEU, CHB, CHD, GIH, JPT, LWK, MEX, MKK, TSI, and YRI. We used (2) tests to identify significantly different loci between these populations. We downloaded SNP allele frequencies from the ALlele FREquency Database to observe the global genetic variation distribution for these specific loci. And then we used Structure software to perform the genetic structure analysis of 12 populations.Based on comparisons of selected available loci, we found that 23, 28, 16, 10, 20, 16, 24, 19, 22, 21 and 36 of the selected VIP variant genotype frequencies in the Lhoba population differed from those of the ASW, CEU, CHB, CHD, GIH, JPT, LWK, MEX, MKK, TSI, and YRI populations, respectively. In addition, Pairwise FST values and clustering analyses also showed the VIP variants in Lhoba exhibited a close genetic affinity with CHD, CHB and JPT populations.Our results complement pharmacogenomic data on the Lhoba ethnic group and may be helpful in the diagnosis of certain diseases in minorities.

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