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Ding Y.,Peoples Hospital of Hainan Province | Yang D.,Huazhong University of Science and Technology | Xun X.,Northwest University, China | Wang Z.,Peoples Hospital of Qionghai | And 6 more authors.
International Journal of COPD

Conclusion: Our results support that IREB2 rs13180 is associated with COPD in Hainan population. And this is the first time the HIF1A polymorphisms in COPD in a Chinese population has been reported, although we failed to find any significant result.Patients and methods: We genotyped 12 single nucleotide polymorphisms in a case-control study with 200 COPD cases and 401 controls from Hainan, People’s Republic of China. Odds ratios and 95% confidence intervals were estimated using the chi-squared (χ2) test, genetic model analysis, haplotype analysis, and stratification analysis.Results: In the genetic model analysis, we found that the genotype T/T of rs13180 of IREB2 decreased the COPD risk by 0.52-fold (P=0.025). But in the further stratification analysis, we failed to find the association between the selected single nucleotide polymorphisms with COPD risk in Han population. In addition, the haplotype analysis of HIF1A gene also was not found to be the possible haplotype associated with COPD risk.Purpose: Chronic obstructive pulmonary disease (COPD) is predicted to become the third most common cause of death and the fifth most common cause of disability in the world by 2020. Recently, variants in the hypoxia-inducible factor 1α (HIF1A), cholinergic receptor, neuronal nicotinic, alpha polypeptide-5, and iron-responsive element-binding protein 2 gene (IREB2) genes were found to be associated with COPD. This study aims to identify whether the variations in these genes are related to COPD in the Hainan population of the People’s Republic of China. © 2015, Ding et al. Source

Hu Q.-Y.,Tibet University | Jin T.-B.,Tibet University | Jin T.-B.,Northwest University, China | Jin T.-B.,National Engineering Research Center for Miniaturized Detection Systems | And 5 more authors.
Tumor Biology

Lung cancer is one of the most common malignant tumors that seriously threaten human health. Current evidence suggests that heredity contributes to the progression of lung cancer. To investigate and validate potential genetic associations with the risk of lung cancer, we conducted a case-control study including 309 cases and 310 controls from Xi'an City, which is located in northwest China, and genotyped six SNPs in five genes, which are related to metabolic process. Overall, our results show that the SNP rs10937405 was associated with a decreased occurrence of lung cancer (OR = 0.72; 95 % CI = 0.56-0.92; p = 0.009). In the genetic models analysis, we found that genotype "CT" of rs10937405 in TP63 was associated with a decreased lung cancer risk (OR = 0.71; 95 % CI, 0.51-0.99; p = 0.031); the genotype "TT" of rs10937405 showed a decreased lung cancer risk in the co-dominant model (OR = 0.53; 95 % CI, 0.30-0.95; p = 0.031). The genotype "CT-TT" of rs10937405 also showed a decreased lung cancer risk in the dominant model (OR = 0.67; 95 % CI, 0.49-0.92; p = 0.014) and the log-additive model (OR = 0.72; 95 % CI, 0.56-0.92; p = 0.0085). The genotype "CC-CT" of rs10937405 confers a higher risk of lung cancer for males than females. Our results, combined with those from previous studies, suggest that genetic variation in TP63 may influence lung cancer susceptibility in the Han population. © 2013 International Society of Oncology and BioMarkers (ISOBM). Source

Shi F.,Northwest University, China | Hui W.,Northwest University, China | Chen C.,National Engineering Research Center for Miniaturized Detection Systems | Cui Y.,Northwest University, China
Journal of Optoelectronics and Advanced Materials

Fe3O4/Au composite nanoparticles were modified with α-thio-ω-carboxy poly (ethylene glycol). Results from selected area diffraction, high-resolution TEM images, and dynamic lighting scattering illustrate that the particles were core/shell composite structure and monodisperse, narrow size distribution. Surface plasmon resonance measured by UV-Vis indicates that the absorption peak of the modified composite particle characteristic at 532 nm can be stably suspended in different buffer. The modified composite particles also have good response to an external magnetic field. The Fe3O4/Au composite nanoparticles are magnetically and optically active, and are useful for simultaneous magnetic and optical detection. Coupled with biomolecular, the advantages of these composite particles make them very promising for biomedical applications in the near future. Source

Wang M.,Northwest University, China | Peng M.-L.,Northwest University, China | Cheng W.,Northwest University, China | Cui Y.-L.,National Engineering Research Center for Miniaturized Detection Systems | Chen C.,National Engineering Research Center for Miniaturized Detection Systems
Journal of Nanoscience and Nanotechnology

A novel and simple method was described to transfer oleic acid stabilized iron oxide nanoparticles from organic solutions to water. The oxidation of OA by sodium periodate in mixed solvents formed a carboxyl group or vicinal diol to make the hydrophobic groups to hydrophilic groups on the surface of the nanoparticles. The characterization of nanoparticles indicated that the phase transfer based on the oxidation of OA was successful performed without change in the size and shape of the iron oxide nanoparticles. The hydrophilic groups on the iron oxide surface stabilized the nanoparticles in aqueous solution and the oxidized nanoparticles can be applied to bimolecular immobilization. Copyright © 2011 American Scientific Publishers. Source

Wang N.,PLA Fourth Military Medical University | Wang L.,Tibet University | Yang H.,Northwest University, China | Zhang H.Q.,Northwest University, China | And 8 more authors.
European Journal of Cancer Prevention

Colorectal cancer (CRC) is a major health burden worldwide and is the second-leading cause of cancer-related death in Europe. CRC is a complex disease resulting from a series of genetic and epigenetic changes that lead to a stepwise progression from normal mucosa to dysplasia and finally to carcinoma. In this study, we present genetic association results between 25 tag single-nucleotide polymorphisms and CRC in a case-control study (203 cases, 296 controls) of a Han Chinese population. We found that rs1143634 in the interleukin-1β (IL1B) gene and rs1800871 in the interleukin-10 (IL10) gene were associated with increased risk for CRC in the Han Chinese. Further haplotype analysis revealed that the 'GAC' in the SMAD7 (mothers against decapentaplegic homolog 7) gene was found to increase CRC risk (odds ratio=1.48; 95% confidence interval, 1.09-2.01; P=0.012). Our results, combined with previous studies, suggest that IL10, PSCA, IL1B, and SMAD7 are significantly correlated with CRC susceptibility in the Han Chinese population. © 2015 Lippincott Williams & Wilkins, Inc. Source

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