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Wu T.,Tianjin University of Science and Technology | Wu T.,Zhejiang University | Yin J.,Tianjin University of Science and Technology | Zhang G.,Shanxi University | And 2 more authors.
Molecular Nutrition and Food Research | Year: 2016

Scope: This study aimed to determine whether cherry anthocyanin (CA) and mulberry anthocyanin (MA) can alleviate oxidative stress and inflammation associated with developing obesity in mice fed with high-fat diet (HFD). Methods and results: CA and MA were added in the daily food of mice throughout the experiment. Sixty mice were randomly divided into two groups: a low-fat diet (LFD, n = 12) group and HFD (n = 48) group. Mice in the HFD group were supplied with a HFD for 8 wks to induce obesity. The HFD-fed mice were then divided into four subgroups for another 8-wk experiment. The subgroups included the control group, HFD plus Orlistat group, and HFD plus CA or MA group, with each group consisting of 12 mice. Consumption of CA and MA at 200 mg/kg food reduced bodyweight gain by 29.6 and 32.7%, respectively, in HFD-fed C57BL/6 mice. CA and MA supplementation could effectively improve the lipid profiles, decrease serum glucose and leptin levels, reduce MDA production, increase SOD and GPX activities, and down-regulate the expression of the TNFα, IL-6, iNOS, and NF-k{cyrillic}B genes. Conclusion: Therefore, MA and CA can potentially alter bodyweight by alleviating oxidative stress and inflammation in diet-induced obesity. Mulberry and cherry anthocyanin (MA, CA) consumption prevents oxidative stress and inflammation in diet-induced obese mice. Consumption of CA and MA at 200 mg/kg food reduced bodyweight gain by 29.6 and 32.7%, respectively, in HFD-fed C57BL/6 mice. CA and BA supplementation could effectively improve the lipid profiles, decrease serum glucose and leptin levels, reduce MDA production, increase SOD and GPX activities, and down-regulate the expression of the TNFα, IL-6, iNOS, and NF-k{cyrillic}B genes. Therefore, MA and CA can potentially alter bodyweight by alleviating oxidative stress and inflammation in diet-induced obesity. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Zheng Q.,Peking Union Medical College | Sun Z.,Peking Union Medical College | Zhang X.,Peking Union Medical College | Yuan J.,National Engineering Laboratory of Southwest Endangered Medicinal Resources Development | And 3 more authors.
Molecules | Year: 2012

Phenolic acid derivatives are typical constituents of Clerodendranthus spicatus which were considered to the active principles of this medicinal plant. These chemical constituents with their interesting frameworks and biological significance attracted our attention. As part of our ongoing chemical investigation of C. spicatus using various column chromatography techniques, a new phenolic compound, named clerodendranoic acid (1), was isolated from the aerial parts of C. spicatus together with five known ones, including rosmarinic acid (2), methyl rosmarinate (3), caffeic acid (4), methyl caffeate (5), ethyl caffeate (6). Their structures, including stereochemical configurations, were completely established by extensive spectroscopic methods, mainly inclvolving 1D, 2D NMR, as well as HRESIMS. © 2012 by the authors. Source


Wu T.,Tianjin University of Science and Technology | Wu T.,Zhejiang University | Jiang Z.,Tianjin University of Science and Technology | Yin J.,Tianjin University of Science and Technology | And 2 more authors.
International Journal of Food Sciences and Nutrition | Year: 2016

This study aimed to evaluate the anti-obesity effects of artificial planting blueberry (Vaccinium ashei) anthocyanin (BA) in high-fat diet-induced obese male C57BL/6 mice. BA at doses of 50, 100, and 200 mg/kg was supplemented in the daily food of obese C57BL/6 mice during an 8-week experiment. Our findings indicate that consumption of BA at high doses reduced body weight by 19.4%, whereas both low and middle doses did not affect the body weight. Furthermore, BA supplementation at high dose could effectively decrease serum glucose, attenuate epididymal adipocytes, improve lipid profiles, and significantly down-regulate expression levels of TNFα, IL-6 PPARγ, and FAS genes. Therefour, BA might alter bodyweight by suppressing fatty acid synthesis and alleviating inflammation. © 2016 Taylor & Francis. Source


Ma G.,Chinese Academy of Sciences | Wu H.,Chinese Academy of Sciences | Yuan J.,National Engineering Laboratory of Southwest Endangered Medicinal Resources Development | Wu L.,Chinese Academy of Sciences | And 6 more authors.
Phytochemistry Letters | Year: 2013

Five phenylpropanoids including one new compound balanophonin A (1), one new natural compound balanophonin B (2) were isolated from the seeds of Lithocarpus pachylepis for the first time. Their structures were elucidated by various spectroscopic techniques (UV, IR, MS, CD, 1D and 2D NMR). All compounds were evaluated for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7. Copyright © 2012 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. Source


Ma G.-X.,Peking Union Medical College | Xu N.,Peking Union Medical College | Yuan J.-Q.,National Engineering Laboratory of Southwest Endangered Medicinal Resources Development | Wei H.,Chinese Institute of Materia Medica | And 4 more authors.
Journal of Asian Natural Products Research | Year: 2012

Two new cassane-type diterpenes, neocaesalpin MR (1) and minaxin C (2), were isolated from Caesalpinia minax HANCE. The structures of these compounds were elucidated by means of spectroscopic analysis. Among these isolated compounds, neocaesalpin MR showed mild activities toward HeLa and colon cancer (HCT-8) human cancer cell lines. © 2012 Copyright Taylor and Francis Group, LLC. Source

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