Entity

Time filter

Source Type


Du X.,Zhejiang Sci-Tech University | Jiang G.,Zhejiang Sci-Tech University | Jiang G.,National Engineering Laboratory for Textile Fiber Materials and Processing Technology Zhejiang | Jiang G.,Key Laboratory of Advanced Textile Materials and Manufacturing Technology ATMT | And 8 more authors.
Colloid and Polymer Science | Year: 2015

The glucose-responsive amphiphilic poly(PEGMA-co-AAPBA) copolymer micelles as drug carriers have been developed using 3-phenylpyruvic acid (3-PPA) as photoinitiator. Under the light irradiation, 3-PPA could be self-polymerized into the trimer structure to execute the emulsifier and initiator functions that confirmed by gas chromatography-mass spectrum (GC-MS) analysis. The structure and morphology of resultant poly(PEGMA-co-AAPBA) micelles were characterized by 1H NMR and TEM. Insulin, as the model drug of diabetes, was loaded into micelles during the photopolymerization process. The as-prepared polymeric micelles exhibited the excellent glucose sensitivity. The loaded insulin could be released from micelles triggered by regulation of temperature and glucose concentration in the environment. The new drug carriers provided a potential application for the therapy of diabetes based on glucose-sensitive controlled drug delivery systems. © 2015, Springer-Verlag Berlin Heidelberg. Source


Jiang T.,Zhejiang Sci-Tech University | Jiang G.,Zhejiang Sci-Tech University | Jiang G.,National Engineering Laboratory for Textile Fiber Materials and Processing Technology Zhejiang | Jiang G.,Key Laboratory of Advanced Textile Materials and Manufacturing Technology ATMT | And 2 more authors.
Materials Research Bulletin | Year: 2016

A simple electrochemical biosensor was developed based on graphitic carbon nitride polymers (g-CN) modified glass carbon electrode (g-CN/GCE). The modified electrode displayed the electrochemical sensitive to dopamine (DA) and showed a good linear and broad response to detect of DA. The inorganic ions had no effect on detecting of DA as well. The decreasing of electrochemical activity was only about 10% after exposure in PBS solution for 15 days which showed excellent stability and reproducibility. It is suggested that the g-CN biosensors have promising application for DA analysis. © 2015 Elsevier Ltd. All rights reserved. Source


Du X.,Zhejiang Sci-Tech University | Jiang G.,Zhejiang Sci-Tech University | Jiang G.,National Engineering Laboratory for Textile Fiber Materials and Processing Technology Zhejiang | Jiang G.,Key Laboratory of Advanced Textile Materials and Manufacturing Technology | And 5 more authors.
Journal of Applied Polymer Science | Year: 2016

Glucose-sensitive and fluorescence copolymer micelles were designed and prepared via a combination of photoinitiated polymerization and enzymatic transesterification. The water-soluble photoinitiator and emulsifier 2-oxooctanoic acid self-polymerized dimer molecules under UV irradiation were characterized by mass spectrometry. The fluorescence dye (9-anthracene alcohol) and biocompatible hydrophilic chains [poly(ethylene glycol)] were introduced to the polymer chains during the photopolymerization and enzymatic transesterification processes. The as-prepared copolymers were confirmed by 1H-NMR spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, and dynamic light scattering. The resulting copolymers exhibited excellent glucose sensitivity and stability against protein. The optical fluorescence properties of the copolymer micelles were investigated with fluorescence spectrophotometry, fluorescence microscopy, and confocal laser scanning microscopy. Because of the amphiphilic feature, the micelles could be self-assembled and used to load insulin. The controlled release of insulin was evaluated and was triggered by glucose in vitro. This study provided a new strategy for fabricating functional carriers as self-regulated insulin-release systems. © 2015 Wiley Periodicals, Inc. Source


Jiang G.,Zhejiang Sci-Tech University | Jiang G.,National Engineering Laboratory for Textile Fiber Materials and Processing Technology Zhejiang | Jiang G.,Key Laboratory of Advanced Textile Materials and Manufacturing Technology ATMT | Jiang T.,Zhejiang Sci-Tech University | And 7 more authors.
RSC Advances | Year: 2014

Au nanoparticles were attached to the surface of polydopamine (PDA) macrospheres by an in situ reduction reaction between PDA and HAuCl4. 4-Mercaptophenyl boronic acid (MPBA) was then modified to form Au-PDA composite particles via a strong Au-S interaction. The resultant MPBA-Au-PDA particles were used in a non-enzyme amperometric glucose sensor. This journal is © the Partner Organisations 2014. Source


Jiang G.,Zhejiang Sci-Tech University | Jiang G.,National Engineering Laboratory for Textile Fiber Materials and Processing Technology Zhejiang | Jiang G.,Key Laboratory of Advanced Textile Materials and Manufacturing Technology ATMT | Du X.,Zhejiang Sci-Tech University | And 7 more authors.
European Polymer Journal | Year: 2014

The multi-sensitive micelles were prepared through a photoinitiated polymerization and self-assembly route using 2-ketobutyric acid (2-KBA) as effective water-soluble photoinitiator and emulsifier. The drug release behaviors were investigated under different glucose concentration, pH and temperature conditions. This work provides a new platform for development drug delivery vehicles with reducing possible utilization of organic solvents and initiators and surfactants. © 2014 Elsevier Ltd. All rights reserved. Source

Discover hidden collaborations