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Gao H.,Chinese Institute of Materia Medica | Gao H.,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines | Wang Z.,Chinese Institute of Materia Medica | Wang Z.,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines | And 2 more authors.
Frontiers of Medicine in China | Year: 2011

Traditional Chinese medicine (TCM) has been widely used for the prevention and treatment of various diseases for a long time in China. Due to its proven efficacy, wide applications, and low side effect, TCM has increasingly attracted worldwide attention. However, one of the biggest challenges facing the clinical practice of TCM is the uncontrollable quality. In this review, the progress of the development and the current status of quality standard as well as new quality control techniques introduced in Chinese Pharmacopoeia (2010 edition), such as liquid chromatography hyphenated mass spectrometry (LC-MS), fingerprint, quantitative analysis of multicomponents by single-marker (QAMS), thin layer chromatography bio-autographic assay (TLC-BAA), and DNA molecular marker technique, are briefly overviewed. © Higher Education Press and Springer-Verlag Berlin Heidelberg 2011.


Li Y.-R.,Chinese Institute of Materia Medica | Li Y.-R.,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines | Xu L.,Chinese Institute of Materia Medica | Li C.,Chinese Institute of Materia Medica | And 5 more authors.
Journal of Asian Natural Products Research | Year: 2014

A phytochemical investigation on the whole plant of Aconitum tanguticum (Ranunculaceae) resulted in the isolation and characterization of two new phenylpropanoid glycosides (1 and 2). Their structures were elucidated as 4-hydroxyphenethoxy-8-O-β-d-[6-O-(4-O-β-d-glucopyranosyl)-sinapoyl] -glucopyranoside (1) and 3,4-dimethoxy-trans-cinnamic acid-9-O-β-d- allopyranoside (2) on the basis of spectroscopic data (1D NMR, 2D NMR, and MS) and comparison with the literature data. © 2014 © 2014 Taylor & Francis.


Li C.,Chinese Institute of Materia Medica | Li C.,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines | Lin L.,Hunan University | Luo M.,Chinese Institute of Materia Medica | And 5 more authors.
Zhongguo Zhongyao Zazhi | Year: 2011

Objective: To study the chemical constituents in the fruits of Siraitia grosvenorii. Method: Isolation and purification of the constituents were carried out on column chromatography. Their structures were identified by NMR and MS spectral analysis. Result: Six compounds were isolated and elucidated as mogroside IIIA1 (1), siamenoside I (2), mogroside IVa (3), mogroside IVe (4), mogroside V (5) and 11-oxo-mogroside V(6), respectively. Conclusion: Compound 1, mogrol-24-O-β-D-glucopyranosyl(1→2)-[β-D- glucopyranosyl(1→6)]-β-D-glucopyranoside, was identified as a new natural product from the fruits of S. grosvenorii.


Xu L.,Chinese Institute of Materia Medica | Li Y.-R.,Chinese Institute of Materia Medica | Li C.,Chinese Institute of Materia Medica | Li C.,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines | And 4 more authors.
Zhongguo Zhongyao Zazhi | Year: 2013

Nineteen compounds were isolated from the whole plants of Aconitum tanguticum by means of various of chromatographic techniques such as silica gel, ODS, sephadex LH-20 and preparative HPLC, and their structures were elucidated as syringin(1), vanillic acid-4-O-β-D-allopyranoside(2), (E)-ferulic acid 4-O-β-D-allopyranoside(3), (E)-ferulic acid-4-O-β-glucopysoside(4), (E)-sinapic acid-4-O-β-glucopyranoside(5), (E)-4-hydroxycinnamyl alcohol 4-O-β-D-glucopyranoside(6), quercetin 3-O-α-L-rhamnopyranosyl-(1→2)- [α-L-rhamnopyranosyl-(1→6)]- β-D-galactopyranoside-7-O-α-L-rhamnopyranoside(7), kaempferol 3-O-α-L-rhamnopyranosyl-(1→2)- [α-L-rhamnopyranosyl-(1→6)]- β-D-galactopyranside-7-O-α-L-rhamnopyranoside(8), quercetin 3-O-α-L-rhamnopyranosyl-(1→6)- β-D-glucopyranoside-7-O-α-L-rhamnopyranoside(9), kaempferol 3-O-[β-D-glucopyranosyl-(1→3)- (4-O-trans-p-coumaroyl)]-α-L-rhamnopyranosyl- (1→6)-β-D-galactopyranside-7-O-α- L-rhamnopyranoside(10), quercetin 3-O-[β-D-glucopyranosyl- (1→3)-(4-O-trans-p-coumaroyl)]- α-L-rhamnopyranosyl-(1→6)-β- D-galactopyranoside-7-O-α-L-rhamnopyranoside(11), salidroside(12), 2-(3, 4-dihydroxyphenyl)ethanol 1-O-β-D-glucopyranoside(13), (7S, 8R)-dehydrodiconiferyl alcohol-9'-O-β-D-glucopyranoside(14), citrusin B(15), heteratisine(16), tanaconitine(17), shanzhiside methyl ester(18)and icariside B1(19). Except compounds 4, 13, 16 and 17, the other compounds were separated from the species for the first time.


Luo M.,Shaanxi University of Chinese Medicine | Luo M.,Chinese Institute of Materia Medica | Luo M.,National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines | Lin L.,Hunan University | And 4 more authors.
Zhongguo Zhongyao Zazhi | Year: 2012

Objective: To study the chemical constituents isolated from the whole plant of Aconitum tanguticum. Method: Chemical constituents were isolated and purified from the title plant by using a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, ODS and preparative HPLC. Their structures were elucidated by spectroscopic techniques including 1H-NMR, 13C-NMR, 2D-NMR, and ESI-MS. Result: Seven compounds were isolated from this plant and their structures were identified as kaempferol-3-O-[α-L-rhamnopyranosyl-(1→6)-β-D- galactopyranoside]-7-O-α-L-rhamnopyranoside (1), kaempferol-3-O-[α- L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside]-7-O-α-L- rhamnopyranoside (2), kaempferol 7-O-α-L-rhamnopyranoside (3), gentiopicroside (4), vomifoliol-9-O-β-D-glucopyranoside (5), dihydrovomifoliol-9-O-β-D-glucopyranoside (6) and 3,4-dihydroxyphenyl alcohol-β-D-glucopyranoside (7). Conclusion: All the compounds were isolated from this plant for the first time.

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