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Chen L.,South China University of Technology | Chen L.,National Engineering Center for Tissue Reconstruction and Restoration | Wu G.,South China University of Technology | Wu G.,National Engineering Center for Tissue Reconstruction and Restoration
Xiyou Jinshu Cailiao Yu Gongcheng/Rare Metal Materials and Engineering | Year: 2014

With PCL-2000 as a soft-segment, HMDI as a hard-segment, PTMG-250 as chain extender, biodegradable polyurethane were synthesized. 5 groups of briodegrable polyurethane material having different characteristics were obtained by adjusting the proportion of the hard-segment, soft-segment and chain extenter. The molecular weight and mechanical properties of all groups were studied. A multilayer scaffold for cartilage tissue engineering was fabricated by the synthesized PU. The pore structure was characterized. ©, 2015, Science Press. All right reserved.


Chen L.,South China University of Technology | Chen L.,National Engineering Center for Tissue Reconstruction and Restoration | Li H.,Jinan University | Deng C.,South China University of Technology | And 7 more authors.
Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering | Year: 2013

Poly(lactic-co-glycolic acid) (PLGA) microspheres containing ofloxacine were made using the double-emulsion (water-in-oil-in-water) solvent extraction/evaporation method. The influences of mesoporous silica, hyaluronic acid, polylysine in internal aqueous solution on the microparticle size distribution, surface morphology, ofloxacine loading efficiency and release behavior were investigated. SEM pictures indicate that microparticles with the microcavities inside are fabricated. The average particle size of Haluronic acid (HA) internal phase group is largest and the span index is smallest. Loading efficiency increases in both mesoporous silica (MS) and HA internal phase groups but decreases in polylysine group. The burst release of all groups is higher than that of the control group. Releasing profiles present the release rates of polylysine internal phase microparticle is fastest, while HA internal phase microparticles present the slowest release rates. The fit curves of the drug release pattern of the microparticles with different internal phases accord with the Slogistic mathematic mode.

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