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Nabavi S.F.,Baqiyatallah Medical Sciences University | Nabavi S.F.,National Elites Foundation of Iran | Nabavi S.M.,Baqiyatallah Medical Sciences University | Nabavi S.M.,National Elites Foundation of Iran | And 3 more authors.
International Journal of Food Properties | Year: 2013

This study is designed to evaluate the antioxidant and antihaemolytic activities of the hydroalcoholic extracts of Allium scabriscapum aerial parts and bulbs by employing eight in vitro assay systems. In 1,1-diphenyl-2-picryl hydrazyl radical scavenging assay, both the extracts show moderate scavenging activity. The reducing power ability of extracts increased with increasing in the samples concentrations. IC50 for metal chelating activity of aerial parts and bulbs extracts were 894.6 ± 31.29 and 746.2 ± 26.11 μg mL-1, respectively. The aerial part extracts show better nitric oxide and hydrogen peroxide scavenging activities than the bulb. Extracts exhibited good antioxidant activity in linoleic acid emulsion system and were comparable to vitamin C (p > 0.05). Aerial parts extract showed better antihemolytic activity against cumene hydroperoxide and hydrogen peroxide-induced hemolysis. Among the extracts A. scabriscapum, aerial parts had higher phenolic and flavonoid contents. Copyright © Taylor & Francis Group, LLC.


Abedini R.,Tehran University of Medical Sciences | Salehi M.,Tehran University of Medical Sciences | Lajevardi V.,Tehran University of Medical Sciences | Beygi S.,Tehran University of Medical Sciences | Beygi S.,National Elites Foundation of Iran
Clinical and Experimental Dermatology | Year: 2015

Summary Background Psoriasis is a chronic, immune-mediated inflammatory skin disease with many extracutaneous manifestations. Several recent studies have indicated an increased prevalence of nonalcoholic fatty liver disease (NAFLD) among patients with psoriasis. In the present study, we investigated the prevalence of NAFLD in a population of Iranian patients with psoriasis. Methods NAFLD was assessed and graded using ultrasonography in 123 patients with psoriasis and 123 healthy controls (HCs) matched by age, sex and body mass index (BMI). Results The prevalence of NAFLD was significantly higher in the psoriatic group compared with the HC group (65.6% vs. 35%, P < 0.01, OR = 3.53). Median NAFLD grade was significantly greater in patients with psoriasis compared with HCs (grade 2 vs. grade 1, P < 0.01). In patients with psoriasis, NAFLD was associated with a higher frequency of hypertension (16.5%), abnormal liver function test (LFT) results (16.4%) and metabolic syndrome (46.6%). Moreover, patients with psoriasis and NAFLD tended to have significantly higher values for BMI, waist circumference (WC), Psoriasis Activity and Severity Index (PASI), and levels of serum triglyceride, cholesterol, low-density lipoprotein and fasting blood sugar (FBS). Multivariate logistic regression revealed that WC, PASI, LFT abnormalities, hypertension and cigarette smoking were independent predictors of NAFLD grade. Conclusions Our findings warrant a detailed assessment of metabolic comorbidities including NAFLD in patients with a primary diagnosis of psoriasis. Lifestyle modifications, including weight loss and smoking cessation, may be necessary for patients with psoriasis to decrease the risk and severity of NAFLD. © 2015 British Association of Dermatologists.


Nabavi S.M.,Baqiyatallah Medical Sciences University | Nabavi S.M.,National Elites Foundation of Iran | Habtemariam S.,University of Greenwich | Nabavi S.F.,Baqiyatallah Medical Sciences University | And 5 more authors.
Molecular and Cellular Biochemistry | Year: 2013

In the present study, the nephroprotective effect of gallic acid isolated from Peltiphyllum peltatum was examined in sodium fluoride (NaF) treated rats. Nephrotoxicity was induced by 1-week intoxication of NaF at 600 ppm through drinking water. The levels of thiobarbituric acid reactive substances, reduced glutathione as well as activities of superoxide dismutase and catalase in renal tissues homogenates were determined. The serum biochemical markers of renal injuries including creatinine, serum urea, blood urea nitrogen, uric acid levels as well as the levels of phosphate and calcium were also assessed. Intoxication with NaF caused a significant increase in the levels of thiobarbituric acid reactive substances (46 % versus to control) and reduced the glutathione concentration (47 %) and the activities of superoxide dismutase (46 %) and catalase (41 %) in renal tissues homogenates. NaF intoxication also induced significant alterations in the kidney biochemical markers increasing the levels of urea, uric acid, blood urea nitrogen, creatinine, and phosphate and decreasing the levels of calcium. Daily administration of gallic acid (20 mg/kg) for 1 week before NaF intoxication brought the antioxidant-oxidant balance similar to the NaF-untreated group. Silymarin, used a standard antioxidant agent, also showed a nephroprotective activity. We concluded that NaF caused nephrotoxicity and oxidative stress in renal tissues and daily administration of gallic acid for 1 week prior to intoxication inhibited toxicity and oxidative stress. © 2012 Springer Science+Business Media New York.


Nabavi S.F.,Baqiyatallah Medical Sciences University | Nabavi S.F.,National Elites Foundation of Iran | Nabavi S.M.,Baqiyatallah Medical Sciences University | Nabavi S.M.,National Elites Foundation of Iran | And 3 more authors.
Bulletin of Environmental Contamination and Toxicology | Year: 2012

Curcumin is well known for its potent antioxidant activity. The result of numerous studies showed that antioxidants can protect against fluoride-induced toxicity. In the present study, protective effects of curcumin against sodium fluoride-induced toxicity in rat erythrocytes were evaluated. Curcumin (10 and 20 mg/kg) and vitamin C (10 mg/kg) were administrated intraperitoneally for 1 week followed by sodium fluoride (600 ppm) treatment for next week. Erythrocytes were isolated and superoxide dismutase and catalase activities as well as the levels of reduced glutathione, and lipid peroxidation were measured. The level of malondialdehyde in sodium fluoride treated rats (595.13 ± 20.23 nmol/g Hb) increased compared to the normal rats (315.44 ± 9.76 nmol/g Hb). Animals which were pretreated with curcumin at 20 mg/kg for 1 week prior to sodium fluoride intoxication showed significant reduction in the malondialdehyde level (320.22 ± 9.28 nmol/g Hb). Also, pretreated with curcumin (20 mg/kg) and vitamin C restored the superoxide dismutase and catalase activities and modified the level of reduced glutathione compared with control group (p > 0.01). © 2011 Springer Science+Business Media, LLC.


Nabavi S.F.,Baqiyatallah Medical Sciences University | Nabavi S.F.,National Elites Foundation of Iran | Habtemariam S.,University of Greenwich | Jafari M.,University of California at Irvine | And 3 more authors.
Bulletin of Environmental Contamination and Toxicology | Year: 2012

Gallic acid is known as a potent antioxidant active compound of the edible and medicinal plant Peltiphyllum peltatum. The main objective of this study was to evaluate the neuroprotective effects of gallic acid against sodium fluoride induced oxidative stress in rat brain. Gallic acid (10 and 20 mg/kg) and vitamin C (10 mg/kg) were intraperitoneally administrated for 1 week prior to sodium fluoride intoxication. After the treatment period, brain tissues were collected and homogenized, and antioxidant parameters were measured in the homogenates. The level of thiobarbituric acid reactive substances in sodium fluoride intoxicated rats (42.04 ± 2.14 nmol MDA eq/g tissue, p < 0.01 vs. normal) increased compared to the normal rats (35.99 ± 1.08 nmol MDA eq/g tissue). Pretreatment with gallic acid at 20 mg/kg was exhibited significant reduction in the thiobarbituric acid reactive substances level (37.06 ± 1.4 nmol MDA eq/g tissue, p > 0.05 vs. normal). This increasing in thiobarbituric acid reactive substances level was accompanied with a decrease in the level of reduced glutathione (6.74 ± 0.28 μg/mg of protein, p < 0.001 vs. normal), superoxide dismutase (53.24 ± 1.62 U/mg of protein, p < 0.001 vs. normal) and catalase (70.73 ± 2.94 lmol/min/mg of protein p < 0.001 vs. normal) activities in sodium fluoride intoxicated rat. Gallic acid at 20 mg/kg was significantly modified the level of reduced glutathione (11.02 ± 0.53 μg/mg of protein, p < 0.05 vs normal) and catalase activity (89.22 ± 3.67 lmol/min/mg of protein, p > 0.05 vs. normal) in rat brain. However, gallic acid at 20 mg/kg was significantly more effective in retrieving superoxide dismutase (124.78 ± 5.7 U/mg of protein) activity than vitamin C (115.5 ± 4.97 U/mg of protein). © Springer Science+Business Media, LLC 2012.


Curti V.,University of Pavia | Capelli E.,University of Pavia | Boschi F.,University of Pavia | Nabavi S.F.,Baqiyatallah Medical Sciences University | And 6 more authors.
Molecular Nutrition and Food Research | Year: 2014

Scope: Methyl-3-O-methyl gallate (M3OMG) possesses in vivo antioxidant activity due to the partial restoration of the antioxidant enzymes, whose expression is altered in oxidative stress. Literature data suggest that miR-17-3p is a microRNA involved in the regulation of cellular redox status, interfering with transcription of the mRNAs responsible for the synthesis of antioxidant enzymes. To obtain deeper insight into the potential mechanism of action of M3OMG, the aim of this study was to investigate its effect on the expression levels of miR-17-3p in human cells. Methods and results: Peripheral blood mononuclear cells and EVC-304 cells were treated with increasing subtoxic concentrations of M3OMG. The expression levels of miR-17-3p, extracted from cells and exosomes, were determined by quantitative real-time PCR. M3OMG induced a decrease in the miR-17-3p levels, and an increase in the levels of mRNA coding for the antioxidant enzymes, when compared to the control samples. Differently, in exosomes the expression levels of miR-17-3p were depended on the compound, its concentration, and the type of cell. Conclusion: These results suggest a potential mechanism of action of M3OMG that, inducing the reduction of the levels of miR-17-3p and the increase of mRNA coding for antioxidant enzymes, allows to these latter to perform their protective effects. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Nabavi S.F.,Baqiyatallah Medical Sciences University | Nabavi S.F.,National Elites Foundation of Iran | Nabavi S.M.,Baqiyatallah Medical Sciences University | Nabavi S.M.,National Elites Foundation of Iran | And 5 more authors.
Industrial Crops and Products | Year: 2013

In the present study, the possible protective effects of gallic acid isolated from Peltiphyllum peltatum against sodium fluoride (NaF)-induced hepatotoxicity and oxidative stress were evaluated. Rats were intoxicated with 600. ppm NaF through drinking water for one week. Gallic acid (10 and 20. mg/kg) and the positive control, silymarin (10. mg/kg) were administrated for seven days prior to NaF intoxication. 24. h after the treatment period, superoxide dismutase and catalase activities, lipid peroxidation and reduced glutathione levels were measured in the liver. Serum biochemical markers including: alanine transaminase, aspartate aminotransferase, alkaline phosphatase, lipase and α-amylase activities and triglyceride, cholesterol, glucose, total bilirubin, direct bilirubin, total protein and albumin levels were determined. The results demonstrated that pretreatment with gallic acid normalized the sodium fluoride-induced alterations in serum parameters and oxidative stress in hepatic tissue. Fluoride intoxication resulted in an increased level of thiobarbituric acid reactive substances (TBARS) (53.05 ± 2.23. nmol MDA equiv./g tissue) in the liver homogenates in comparison with control group (25.03 ± 1.27. nmol MDA equiv./g tissue). Pretreatment with gallic acid at 20. mg/kg demonstrated significant mitigation in TBARS level (33.95 ± 2.51. nmol MDA equiv./g tissues). Fluoride intoxication did also suppress the superoxide dismutase and catalase activity of hepatic tissue homogenates by 33.87% and 66.87%, respectively. Treatment with gallic acid resulted in a dose-dependent mitigation of the fluoride-mediated suppression of antioxidant enzymes. In conclusion, gallic acid prevented the NaF-induced abnormalities in the serum and hepatic biochemical markers. © 2012 Elsevier B.V.


Nabavi S.M.,Baqiyatallah Medical Sciences University | Nabavi S.M.,National Elites Foundation of Iran | Nabavi S.F.,Baqiyatallah Medical Sciences University | Nabavi S.F.,National Elites Foundation of Iran | And 2 more authors.
Food Chemistry | Year: 2012

The protective effects of quercetin against sodium fluoride induced oxidative stress were examined in rat's liver. Rats were divided into five groups. The first group served as normal group that was treated with standard diet. The second group was intoxicated with sodium fluoride (600 ppm) through drinking water for 1 week. The third, fourth and fifth groups were treated with quercetin at a dose of 10 and 20 mg/kg and vitamin C (as the positive control) at a dose of 10 mg/kg intraperitoneally for 1 week before sodium fluoride intoxication, respectively. After 1 week, activities of superoxide dismutase and catalase, level of reduced glutathione and lipid peroxidation end product were determined in the homogenates of rat liver. The results of the present study suggested that quercetin protects rat liver from sodium fluoride induced oxidative stress, probably via its antioxidant activity. © 2011 Elsevier Ltd. All rights reserved.


Nabavi S.F.,National Elites Foundation of Iran | Nabavi S.M.,Baqiyatallah Medical Sciences University | Moghaddam A.H.,University of Mazandaran | Naqinezhad A.,University of Mazandaran | And 2 more authors.
Food and Function | Year: 2012

Allium paradoxum (M.Bieb.) G. Don is a locally known vegetable and is utilized for preparation a variety of local foods in northern of Iran. This study was conducted to quantitatively evaluate the recovery effects of A. paradoxum on gentamicin-induced nephrotoxicity in mice. The curative effect of extracts from the aerial parts and bulbs of A. paradoxum against gentamicin-induced renotoxicity in mice was determined. Both extracts at the dose 200 mg kg -1 day -1 offered nephroprotective effect by change in the blood urea nitrogen and creatinine. No statistical difference could be obtained in serum creatinine and blood urea nitrogen of bulb-treated mice compared to normal mice. The result show that bulb extract at 200 mg kg -1 day -1 has better activity than aerial parts. © 2012 The Royal Society of Chemistry.


Nabavi S.F.,National Elites Foundation of Iran | Moghaddam A.H.,University of Mazandaran | Eslami S.,Mazandaran University of Medical Sciences | Nabavi S.M.,National Elites Foundation of Iran | Nabavi S.M.,University of Mazandaran
Biological Trace Element Research | Year: 2012

In the present study, the protective effect of curcumin against sodium fluoride-induced nephrotoxicity was evaluated in rats. Renal injury was induced by daily administration of 600 ppm sodium fluoride in drinking water for 1 week. One week before the administration of fluoride, the animals selected as study group were given curcumin (10 and 20 mg/kg body weight, intraperitoneally). After 1 week, lipid peroxidation level, activities of superoxide dismutase, catalase, and level of glutathione in kidney homogenate were measured. Blood serum samples were examined for creatinine, serum urea, and blood urea nitrogen levels. Another group of rats received vitamin C (10 mg/kg) as standard antioxidant. The results show that curcumin and vitamin C treatment prior to fluoride administration normalized the levels of serum creatinine, serum urea, and blood urea nitrogen. Moreover, curcumin and vitamin C administrations prevented the antioxidant enzyme decreasing and lipid peroxidation levels imbalance. In conclusion, curcumin treatment at the doses of 10 and 20 mg/kg (intraperitoneally) showed significant nephroprotective effects. © 2011 Springer Science+Business Media, LLC.

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