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Ebrahimzadeh M.A.,Mazandaran University of Medical Sciences | Eslami S.,Mazandaran University of Medical Sciences | Nabavi S.F.,National Elites Foundation of Iran | Nabavi S.M.,National Elites Foundation of Iran | Nabavi S.M.,University of Mazandaran
Biological Trace Element Research | Year: 2011

The concentrations of Cr, Cu, Fe, Mn, Ni, Pb, Cd, and Zn were determined in the brain, heart, liver, gill, gonad, spleen, kidney, and red and white muscles of Liza saliens (leaping mullet). Trace element levels in fish samples were analyzed by flame atomic absorption spectrometry. Among the non-essential metals, the levels of Ni and Pb in the tissues were higher than limits for fish proposed by FAO/WHO, EU, and TFC. Generally, the levels of the non-essential metals were much higher than those of manganese in the red and white muscles. Fe distribution pattern in tissues was in order of spleen>liver>heart> gill>brain>kidney>gonad>red muscle>white muscle. Red muscle was not within the safe limits for human consumption because non-essential metal (Ni, Pb) contents were higher than standard limits. © Springer Science+Business Media, LLC 2011.


Eslami B.,Islamic Azad University | Nabavi S.F.,National Elites Foundation of Iran | Nabavi S.M.,University of Mazandaran | Ebrahimzadeh M.A.,Mazandaran University of Medical Sciences | Mahmoudi M.,Mazandaran University of Medical Sciences
European Review for Medical and Pharmacological Sciences | Year: 2011

Objectives: Hypericum spp. (H.) has been used in traditional medicine for their sedative effect for many years. In spite of many works on this genus, little is known about H. scabrum. In this work antidepressant and its protective effect against hypoxia-induced lethality were evaluated. Materials and Methods: Antidepressant and its protective effects against hypoxia-induced lethality were evaluated. Antidepressant activity was determined by forced swimming test (FST) and tail suspension test (TST). Antihypoxic activities were determined by asphytic, haemic and circulatory hypoxia models in mice. Also, hydrogen peroxide scavenging activity and cumene hydroperoxide (CuOOH) induced hemolysis also were investigated. Results: At all tested doses H. scabrum significantly and dose dependently reduced the immobility periods in FST and TST. Also, extract showed statistically significant antihypoxic activities in three asphytic, haemic and circulatory hypoxia models in mice. The extract showed moderately good scavenging activity with IC50 = 518.8±20.7 μg ml -1. Extract inhibited significantly CuOOH induced hemolysis in red blood cells (RBC). Conclusions: H. scabrum aqueous extract showed remarkable antihypoxic and antidepressant effects thus, lend pharmacological justification to the use of the plant extract by traditional medicine practitioners. Mechanism of antidepressant activity of extract may be through nitric oxide pathway.


Rabiei K.,Mazandaran University of Medical Sciences | Bekhradnia S.,Mazandaran University of Medical Sciences | Nabavi S.M.,University of Mazandaran | Nabavi S.F.,National Elites Foundation of Iran | Ebrahimzadeh M.A.,Mazandaran University of Medical Sciences
Natural Product Research | Year: 2012

The effects of two extracting methods on the total phenolic and total flavonoid contents of Crataegus pentagyna subsp. elburensis Waldst. & Kit. ex Willd fruit extracts were investigated. Antioxidant activities of polyphenol (PP) fraction and ultrasonic (US) extraction were evaluated with four different invitro antioxidant tests. IC50 for DPPH radical-scavenging activity was 32.2±1.6 for PP fraction and 36.7±1.5μgmL1 for US extract. Reducing powers of extracts increased with the increase of their concentrations. PP fraction exhibited high reducing power at 2-32μgmL 1. Extracts exhibited good H2O2 radical scavenging and Fe2+ chelating ability. Their high phenolic and flavonoid contents could be responsible for their antioxidant activity and pharmacologic actions. © 2012 Copyright Taylor and Francis Group, LLC.


Nabavi S.M.,Baqiyatallah Medical Sciences University | Nabavi S.F.,National Elites Foundation of Iran | Alinezhad H.,University of Mazandaran | Zare M.,University of Mazandaran | Azimi R.,University of Mazandaran
European Review for Medical and Pharmacological Sciences | Year: 2012

OBJECTIVES, Eryngium (E.) caucasicum was found as a new cultivated vegetable plant in northern Iran and used in several local foods. Little information is available on biological properties of E. caucasicum. In this work antioxidant activity of flavonoid-rich fraction of this plant was investigated by eight in vitro assay systems. MATERIALS AND METHODS, 1,1-diphenyl-2- picryl hydrazyl radical (DPPH), nitric oxide and hydrogen peroxide scavenging activities, Fe2+ chelating ability, reducing power and hemoglobin- induced linoleic acid peroxidation were used to evaluate antioxidant activities. Antihemolytic activities were evaluated against CuOOH and H2O 2 induced hemolysis in rat erythrocyte. RESULTS, IC50 for DPPH scavenging activity was 391.2 ± 14.9, 706.6 ± 22.3 and 779.7 ± 16.7 μg ml-1 for aqueous (AQ), ethyl acetate (EA) and nhexane (HE) fractions, respectively. There was no difference between reducing power of AQ fraction activity and vitamin C (p > 0.05). IC50 for NO radical-scavenging activity was in order of AQ (133.5 ± 6.2 μg ml -1) > EA (350.1 ± 14.8 μg ml-1) > and HE (639.9 ± 21.7 μg ml-1) fractions, respectively. Extracts showed weak Fe2+ chelating ability. HE fraction showed better activity (173.5 ± 9.6 μg ml-1). Extracts exhibited weak hydrogen peroxide scavenging activity but exhibited very good antioxidant activity against the hemoglobin- induced linoleic acid peroxidation. There was no significant difference between AQ fraction and vitamin C (p > 0.01). Fractions delayed the onset of the CuOOH induced hemolysis. AQ fraction showed very high total phenol and flavonoid contents which was higher than other fractions. High phenol and flavonoid content of AQ fraction may lead to its better antioxidant activity. CONCLUSIONS, E. caucasicum fractions exhibited different levels of antioxidant and antihemolytic activities in all tested models. These results can be useful as a starting point of view for further applications of E. caucasicum aerial parts or its constituents in pharmaceutical preparations.


Nabavi S.F.,National Elites Foundation of Iran | Nabavi S.M.,Baqiyatallah Medical Sciences University | Moghaddam A.H.,University of Mazandaran | Naqinezhad A.,University of Mazandaran | And 2 more authors.
Food and Function | Year: 2012

Allium paradoxum (M.Bieb.) G. Don is a locally known vegetable and is utilized for preparation a variety of local foods in northern of Iran. This study was conducted to quantitatively evaluate the recovery effects of A. paradoxum on gentamicin-induced nephrotoxicity in mice. The curative effect of extracts from the aerial parts and bulbs of A. paradoxum against gentamicin-induced renotoxicity in mice was determined. Both extracts at the dose 200 mg kg -1 day -1 offered nephroprotective effect by change in the blood urea nitrogen and creatinine. No statistical difference could be obtained in serum creatinine and blood urea nitrogen of bulb-treated mice compared to normal mice. The result show that bulb extract at 200 mg kg -1 day -1 has better activity than aerial parts. © 2012 The Royal Society of Chemistry.

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