National Dong Hwa University | Date: 2016-11-04
The present application provides a composition comprising a core formed by gold nanoparticle, a compound of Formula (I): wherein dashed lines in Formula (I) represent (i) with or without an attachment of benzol group, (ii) a delocalized bond where shown within a ring; R_(1 )is hydrogen or a halogen; R_(2 )is a linker selected from C_(6-20 )alkyl or polyethylene glycol; R_(3 )is C_(1-20 )alkyl, C_(1-20 )substituted alkyl, hexadecanyl amido, pyridinyl, benzyl or pyrimidinyl; and a compound of Formula (II): wherein dashed lines, R_(1), R_(2 )and R_(3 )are defined as in Formula (II), and M is a metal. The composition has an inhibition ability against a cancer.
Chiou S.-W.,National Dong Hwa University
Computers and Operations Research | Year: 2014
For area traffic control road network under realization of uncertain travel demand, a robust signal setting is investigated in this paper. Due to certain hierarchy in a decision-making order, a min-max bilevel program is proposed. A new solution method is presented to determine a Nash-Stackelberg solution where a proposed signal setting is found for area traffic control under demand uncertainty. In order to investigate the robustness of the proposed signal settings, numerical computations are performed for various initial data sets in a medium-sized example road network. Good computational results indicated that the proposed signal settings can successfully reduce a worst-case travel cost substantially while incurring a relatively slight loss of optimality with respect to the optimal deterministic solutions for nominal travel demands. Particularly, our computation results showed that the proposed signal settings become even attractive as demand growth increases under a worst-case realization taken by uncertain travel demands. © 2013 Elsevier Ltd. All rights reserved.
National Dong Hwa University | Date: 2013-06-07
A manufacturing method of a solar cell includes the following steps, providing a substrate, which includes a first conductivity type semi-conductor layer and a second conductivity type semi-conductor layer. The conductivity type of the first conductivity type semi-conductor layer is opposite to the conductivity type of the second conductivity type semi-conductor layer. A graphene oxide layer is formed on the substrate and the graphene oxide layer contacts with the second conductivity type semi-conductor layer. A first electrode and a second electrode are formed on the substrate. The first electrode contacts with the first conductivity type semi-conductor layer, and the second electrode contacts with the second conductivity type semi-conductor layer.
National Dong Hwa University | Date: 2013-05-20
A signal denoising method for a frequency-scan ion trap mass spectrometer includes reading a signal raw data array observed in the spectrometer. The signal raw data array is processed by Boxcar averaging method to obtain a first signal array. Then the first signal array is processed by a harmonic interference cancellation method to obtain a second data array. Next the second signal array is processed by a radio frequency interference reduction method and a third signal array without the background induced from driving voltage of ion trap is reconstructed according to the second signal array.
National Dong Hwa University | Date: 2014-01-22
The present invention relates to a method or composition for treating diabetes mellitus, comprising administering a subject with a pharmaceutical composition comprising a therapeutically effective amount of an active compound from Antrodia camphorate, such as antroquinonols, and a pharmaceutically acceptable carrier. In addition, the prevent invention provides a new process for the total synthesis of antroquinonol. Also provided are the new compounds produced during the process for preparing of antroquinonol.
National Dong Hwa University | Date: 2013-06-26
Provided is a method for treating a liver injury such as fibrosis, cirrhosis and hepatitis as well as a method for restoring liver function in a subject, which includes administrating to the subject a therapeutically effective amount of n-butylidenephthalide having the formula (1) as an active ingredient, or a pharmaceutically acceptable salt of ester thereof:_(2)CH_(2)CH_(3), and n-butylidenephthalide (I) is E form, Z form or a mixture thereof.
National Dong Hwa University | Date: 2015-04-14
This invention relates to a pharmaceutical formulation containing z-butylidenephthalide and a polymer, e.g., a polyanhydride. Also disclosed is use of this formulation to treat tumor.
National Dong Hwa University | Date: 2015-02-25
The present invention provides a novel formulation for cancer treatment and a method for enhancing the HCDs efficacy in cancer treatment. Specifically, the present invention provides copper-modified silica nanoparticles loaded with HCD, which exhibits better efficacy than some conventional anticancer drugs.
National Dong Hwa University | Date: 2013-11-12
The present invention relates to a method or composition for glycemic control in a subject, which is effective for treating diabetes mellitus, comprising administering the subject with a pharmaceutical composition comprising a therapeutically effective amount of an aliphatic alcohol having a general formula of CH_(3)(CH_(2))_(n)CH_(2)OH, wherein n is an integer from 10 to 40, such as tetracosanol, and a pharmaceutically acceptable carrier.
National Dong Hwa University | Date: 2013-03-14
A method of detecting Mycobacterium tuberculosis complex (MTBC) in a culture media is provided, in which, the culture media containing the MTBC and a biomarker, such as CFP-10, secreted from the MTBC is provided, the culture media is filtered to obtain a filtrate, detonation nanodiamond particles are mixed with the filtrate to form biomarker-loaded detonation nanodiamond particles, and a mass spectrometry analysis process is performed on the biomarker-loaded detonation nanodiamond particles for detecting the biomarker.