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Karda B.,Desh Bhagat Dental College & Hospital | Jindal R.,National Dental College & Hospital | Sandhu S.,Civil Hospital | Sharma S.,Bhojia Dental College Hospital | Kaur R.,JCD Dental College & Hospital
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: With the enormous change in life style pattern of a common man through the past few decades, there has been proportional variation in the amount and frequency of consumption of drinks. An increased consumption of these drinks will concurrently increase enamel surface roughness by demineralization, resulting in hypersensitivity and elevated caries risk. Aim: The present study was designed to evaluate the erosive potential of commercially available drinks on tooth enamel and various tooth coloured restorative materials. Materials and Methods: Extracted human teeth were taken and divided into four groups i.e. tooth enamel, glass ionomer cement, composite and compomer. Four commercially available drinks were chosen these were Coca -Cola, Nimbooz, Frooti and Yakult. The pH of each drink was measured. Each group was immersed in various experimental drinks for a period of 14 days. The erosive potential of each drink was measured by calculating the change in average surface roughness of these groups after the immersion protocol in various drinks. The data analysis was done by One Way Anova, Post-Hoc Bonferroni, and paired t -test. Results: Group II-GIC showed highest values for mean of change in average surface roughness and the values were statistically significant (p<0.001) with tooth enamel, composite and compomer (p=0.002). Coca-cola showed the highest erosive potential and Yakult showed the lowest, there was no statistical significant difference between the results shown by Yakult and Frooti. Conclusion: Characteristics which may promote erosion of enamel and tooth coloured restorative materials were surface texture of the material and pH of the drinks. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.

Grover V.,National Dental College & Hospital | Kapoor A.,National Dental College & Hospital | Malhotra R.,National Dental College & Hospital | Sachdeva S.,National Dental College & Hospital
Current Gene Therapy | Year: 2014

Epigenetics means gene expression alterations which occur due to the biochemical changes of the nucleotides modifying structure of DNA rather than the changes in the genetic code itself as in case of mutations. The epigenome, consisting of chromatin and its modifications, acts as a link between the inherited genome and the changes imposed by the environment. Over the past decade, there has been mounting evidence suggestive of associations between epigenetic modifications and various human conditions such as aging, and most common human diseases viz. cancer, cardiovascular diseases, diabetes, rheumatoid arthritis, HIV etc and the clearest evidence as the central mechanism for common multifactorial diseases, has been identified with the factors involved in the inflammatory response. Periodontal disease, basically an immune-inflammatory affliction, being a multifactorial complex disease, owing to its high prevalence, chronicity and wide ranging systemic effects, essentially calls for a better comprehension of the underlying disease mechanisms, so as to develop and decipher the novel methodologies to combat this disease. The current paper aims to visualize periodontal disease from an epigenetic perspective, featuring the contemporary evidence supported literature and tends to explore the possibilities to find some explanations for perio-systemic health links, individualized and improvised diagnostic tools for earlier detection and ways to halt the disease and help regeneration and reconstruction of the lost periodontal attachment apparatus with the biology based approaches. © 2014 Bentham Science Publishers.

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