National Chung Hsing University , colloquially known in Chinese as Xingda ,is a research-led comprehensive university in South District, Taichung, Taiwan. According to Ministry of Education rankings, it is the best university in central Taiwan.Currently, NCHU is among the four universities of Taiwan's Public Ivy - the Taiwan Comprehensive University System. Wikipedia.
Lin T.-I.,National Chung Hsing University
Statistics and Computing | Year: 2010
This paper presents a robust mixture modeling framework using the multivariate skew t distributions, an extension of the multivariate Student's t family with additional shape parameters to regulate skewness. The proposed model results in a very complicated likelihood. Two variants of Monte Carlo EM algorithms are developed to carry out maximum likelihood estimation of mixture parameters. In addition, we offer a general information-based method for obtaining the asymptotic covariance matrix of maximum likelihood estimates. Some practical issues including the selection of starting values as well as the stopping criterion are also discussed. The proposed methodology is applied to a subset of the Australian Institute of Sport data for illustration. © 2009 Springer Science+Business Media, LLC.
Weng C.-J.,Tainan University of Technology |
Yen G.-C.,National Chung Hsing University
Cancer Treatment Reviews | Year: 2012
Cancer metastasis is the major cause of cancer-related death, and chemoprevention is defined as the use of natural or synthetic substances to prevent cancer formation or cancer progress. Evidence that phenolic compounds may have a potential inhibitory effect on cancer invasion and metastasis is increasingly being reported in the scientific literature. Curcumin, resveratrol, and their related derivatives are the most studied compounds in this topic so far; gallic acid, chlorogenic acid, caffeic acid, carnosol, capsaicin, 6-shogaol, 6-gingerol, and their corresponding derivatives are also suggested to be the active members of the phenolic family on anti-invasion and anti-metastasis. Because metastasis occurs through a multistep process, these bioactives might act on a variety of stages of the metastatic process to prevent tumor cells from metastasizing. This review summarizes the common protein targets and signaling pathways for the inhibition of invasion and metastasis as well as past publications on the in vitro and in vivo effects and molecular mechanisms of phenolic acids, monophenol, polyphenol, and their derivatives, except flavonoids, on cancer invasion and metastasis. Based on these data, we conclude that the daily consumption of natural dietary components that are rich in phenolics could be beneficial for the prevention of cancer metastasis. © 2011 Elsevier Ltd.
San J.-Y.,National Chung Hsing University
Energy | Year: 2010
Exergy change rate in an ideal gas flow or an incompressible flow can be divided into a thermal exergy change rate and a mechanical exergy loss rate. The mechanical exergy loss rates in the two flows were generalized using a pressure-drop factor. For heat exchangers using in waste heat recovery, the consumed mechanical exergy is usually more valuable than the recovered thermal exergy. A weighing factor was proposed to modify the pressure-drop factor. An exergy recovery index (ηII) was defined and it was expressed as a function of effectiveness (ε), ratio of modified heat capacity rates (C*), hot stream-to-dead-state temperature ratio, cold stream-to-dead-state temperature ratio and modified overall pressure-drop factor. This ηII-ε relation can be used to find the ηII value of a heat exchanger with any flow arrangement. The ηII-Ntu and ηII-Ntuh relations of cross-flow heat exchanger with both fluids unmixed were established respectively. The former provides a minimum Ntu design principle and the latter provides a minimum Ntuh design principle. A numerical example showed that, at a fixed heat capacity rate of the hot stream, the heat exchanger size yielded by the minimum Ntuh principle is smaller than that yielded by the minimum Ntu principle. © 2010 Elsevier Ltd. All rights reserved.
Huang C.-C.,National Chung Hsing University
Optics Express | Year: 2013
This study reports a symmetric hybrid plasmonic waveguide consisting of a cylindrical metal nanowire surrounded by low-index SiO2 and high-index Si covered with SiO2. The symmetric circumambience relative to the metal nanowire significantly facilitates the present design to minimize the energy attenuation resulting from Ohmic losses while retaining highly confined modes guided in the low-index nanoscale gaps between the metal nanowire and the high-index Si. The geometric dependence of the mode characteristics on the proposed structure is analyzed in detail, showing long propagation lengths beyond 10 mm with normalized mode areas on the order of 10-2. In addition to enabling the building of long-range plasmonic circuit interconnects, the compactness and high-density integration of the proposed structure are examined by analyzing crosstalk in a directional coupler composed of two such waveguides and bending losses for a 90° bend. A relatively short coupling length of 1.16 μm is obtained at a center-to-center separation of 0.26 μm between adjacent waveguides. Increasing the separation to 1.65 μm could completely prevent coupling between waveguides. Power transmission exceeds 80% in the case of a 90° bend with small radius of curvature of 0.5 μm. Moreover, the dependence of spectral response on coupling length and the transmission of a 90° bend, ranging from telecom wavelengths of 1.40 to 1.65 μm, are investigated. Over a wide wavelength range, a strong coupling length dependence on wavelength and a high transmission for a 90° bend also make the proposed plasmonic waveguide promising for the realization of wavelength-selective components. © 2013 Optical Society of America.
Huang C.-C.,National Chung Hsing University
IEEE Journal on Selected Topics in Quantum Electronics | Year: 2012
The proposed hybrid plasmonic waveguide comprises a semiconductor cylindrical nanowire embedded in a low-index dielectric above a metallic substrate with two grooves carved into the surface, between which a nanoscale metallic ridge is formed. Comparing the original hybrid plasmonic structure having a flat metal surface with the proposed structure significantly reduces the lateral mode size of the hybrid modes, and moderately increases the propagation distance. The mode area and propagation distance dependences on the geometry and material parameters are studied. A parametric plot of the figure of merit shows that the proposed structure outperforms the original hybrid structure. The mode performances can be improved further by rounding the metallic ridge corners with the maximum radius. Under an equal confinement of light, the propagation distance of the present structure is three times larger than that of the previously published hybrid structure. © 2012 IEEE.