Chiayi City, Taiwan
Chiayi City, Taiwan

National Chiayi University is a public university located in Chiayi City and Chiayi County, Taiwan. It was formed in 2000 by merging National Chiayi Institute of Technology and National Chiayi Teachers College. The University has six colleges, which include seven doctoral programs, 42 full-time master's degree programs, twelve part-time master's degree programs, and 38 undergraduate programs now. NCYU is one of the oldest and largest universities in southern Taiwan. Wikipedia.

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Lin S.-Y.,Yuanpei University | Wang S.-L.,National Chiayi University
Advanced Drug Delivery Reviews | Year: 2012

The solid-state chemistry of drugs has seen growing importance in the pharmaceutical industry for the development of useful API (active pharmaceutical ingredients) of drugs and stable dosage forms. The stability of drugs in various solid dosage forms is an important issue because solid dosage forms are the most common pharmaceutical formulation in clinical use. In solid-state stability studies of drugs, an ideal accelerated method must not only be selected by different complicated methods, but must also detect the formation of degraded product. In this review article, an analytical technique combining differential scanning calorimetry and Fourier-transform infrared (DSC-FTIR) microspectroscopy simulates the accelerated stability test, and simultaneously detects the decomposed products in real time. The pharmaceutical dipeptides aspartame hemihydrate, lisinopril dihydrate, and enalapril maleate either with or without Eudragit E were used as testing examples. This one-step simultaneous DSC-FTIR technique for real-time detection of diketopiperazine (DKP) directly evidenced the dehydration process and DKP formation as an impurity common in pharmaceutical dipeptides. DKP formation in various dipeptides determined by different analytical methods had been collected and compiled. Although many analytical methods have been applied, the combined DSC-FTIR technique is an easy and fast analytical method which not only can simulate the accelerated drug stability testing but also at the same time enable to explore phase transformation as well as degradation due to thermal-related reactions. This technique offers quick and proper interpretations. © 2012 Elsevier B.V.

Taipei Veterans General Hospital, National Chiayi University and Mackay Memorial Hospital | Date: 2014-11-21

Novel N-substituted norcantharimide derivatives are disclosed herein. The novel N-substituted norcantharimide derivatives are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly for treating leukemia.

Lin W.-S.,National Chiayi University
International Journal of Human Computer Studies | Year: 2012

Virtual learning system (VLS) is an information system that facilitates e-learning have been widely implemented by higher education institutions to support face-to-face teaching and self-managed learning in the virtual learning and education environment (VLE). This is referred to a blended learning instruction. By adopting the VLS, students are expected to enhance learning by getting access to course-related information and having full opportunities to interact with instructors and peers. However, there are mixed findings revealed in the literature with respect to the learning outcomes in adopting VLS. In this study, we argue that the link between the precedents of leading students to continue to use VLSs and their impacts on learning effectiveness and productivity are overlooked in the literature. This paper aims to tackle this question by integrating information system (IS) continuance theory with task-technology fit (TTF) to extend our understandings of the precedents of the intention to continue VLS and their impacts on learning. By doing it, factors of technology-acceptance-to-performance, based on TAM (technology acceptance model) and TTF and post-technology-acceptance, based on expectation-confirmation theory, models can be included to test in one study. The results reveal that perceived fit and satisfaction are important precedents of the intention to continue VLS and individual performance. Later, a discussion and conclusions are provided. This study sheds light on learning system design as assisted by IS in VLE and can serve as a basis for promoting VLS in assisting learning. © 2012 Elsevier Ltd.

Chu H.-C.,National Chiayi University
Accident Analysis and Prevention | Year: 2014

High-deck buses that have a higher center of gravity traveling at an excessive speed have a higher likelihood of causing serious and fatal accidents when drivers lose control of the vehicle. In addition, drivers who suffer from fatigue in long-distance driving increase the likelihood of serious accident. This paper examines the effects of risk factors contributing to severe crashes associated with high-deck buses used for long-distance driving on freeways. An ordered logit and latent class models are used to examine significant factors on the severity of injuries in crashes related to high-deck buses. Driver fatigue, drivers or passengers not wearing a seat belt, reckless driving, drunk driving, crashes occurred between midnight and dawn, and crashes occurred at interchange ramps were found to significantly affect the severity of injuries in crashes involving high-deck buses. Safety policies to prevent severe injuries in crashes involving high deck buses used for long-distance runs on freeways include: (1) restricting drivers from exceeding the limit of daily driving hours and mandating sufficient rest breaks; (2) installing an automatic sleep-warning device in the vehicle; (3) drivers with obstructive sleep apnea syndrome or sleep disorders should be tested and treated before they are allowed to perform long hours of driving tasks; (4) educating the public or even amending the seatbelt legislation to require all passengers to wear a seat belt and thus reduce the chance of ejection from a high-deck bus and prevent serious injuries in a crash while traveling at a higher speed on freeways. © 2013 Elsevier Ltd. All rights reserved.

Su M.-D.,National Chiayi University
Chemistry - A European Journal | Year: 2013

The mechanisms of the photochemical isomerization reactions were investigated theoretically by using a model system of 1,2-dihydro-1,2-azaborine with the CAS(6,6)/6-311G(d,p) and MP2-CAS-(6,6)/6-311++G(3df,3pd)//CAS(6,6)/6- 311G(d,p) methods. Three reaction pathways, which lead to three kinds of photoisomers, have been examined. The structures of the conical intersections, which play a decisive role in such photorearrangements, were obtained. The thermal (or dark) reactions of the reactant species have also been examined by using the same level of theory to assist in providing a qualitative explanation of the reaction pathways. The model investigations suggest that the preferred reaction route for 1,2-dihydro-1,2-azaborine, which leads to the Dewar 1,2-dihydro-1,2-azaborine photoproduct, is as follows: reactant→Franck- Condon region→conical intersection→photoproduct. The results obtained allow a number of predictions to be made. Photoisomer pathways: The ground- and 1(ππ*)-state potential energy surfaces of 1,2-dihydro-1,2-azaborine species were studied with CAS/6-311G(d,p) and MP2-CAS/6-311++G(3df,3pd) methods. Three reaction pathways were examined (see figure). The theoretical results are in good agreement with the available experimental observations for the photorearrangement reactions under singlet direct or sensitized irradiation. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Liu P.-L.,National Chiayi University
Computers and Education | Year: 2011

This study aims to examine the effect of using computerized concept maps during the pre-writing phase on learners' writing performance. The research questions were: (1) What are the impacts of different computerized concept mapping treatments (no-mapping, individual-mapping, and cooperative-mapping) on writing performance for learners of different writing proficiencies (high-level, middle-level, and low-level)? (2) Does the quality of the concept maps constructed cooperatively exceed the quality of the concept maps constructed individually? (3) Does the map quality correlate to the learner's writing performance? Ninety-four freshmen enrolled in an English course were divided into high-level, middle-level, and low-level learners according to their baseline writing scores. The experimental part of the study took place over two-hour class periods for nine weeks. All participants went through all three treatments for accomplishing three writing assignments. It was found that both computerized mapping treatments had equally positive effects on low-level and middle-level learners compared with the no-mapping treatment. However, high-level learners performed significantly better with the individual-mapping treatment than with the other two treatments. The quality of the concept maps constructed cooperatively exceeded the quality of those constructed individually. The quality of the maps was also correlated to the learners' writing performance. © 2011 Elsevier Ltd. All rights reserved.

Lin S.-C.,National Chiayi University
IEEE Transactions on Microwave Theory and Techniques | Year: 2011

Microstrip quad-band bandpass filters with controllable passband center frequencies are presented and intensively investigated in this study. The newly proposed quad-band filter principally comprises two dual-band filters. Specifically, the two distinct types of dual-band filters with different dual-band generating mechanisms are studied and then combined to provide the quad-band responses. By incorporating parallel coupled lines as input sections and interstage impedance inverters built with quasi-lumped inductors, the type-I filter is constructed with thorough network analysis. As for the type-II filter, with novel quad-pole-splitting techniques analyzed by mixed-mode S-parameters, dual passbands of close band proximity could be realized. Eventually, based on the parallel-path transmission theory along with the two dual-band filters, a novel quad-band filter is thus implemented. The measurement and simulation results show good agreement. © 2011 IEEE.

Wang S.H.,National Chiayi University
Journal of agricultural and food chemistry | Year: 2011

In an attempt to elevate temperature to facilitate glycation, a nonenzymatic reaction by incubation of bovine serum albumin (BSA) and fructose at 50 °C for 24 h has been developed. As conducted and compared to a routine procedure by incubation of BSA and fructose at 37 °C for 168 h, the reactant fluorescence intensities and SDS-PAGE-detected glycated BSA quantities produced by both test temperatures increased with time of incubation. As the Amadori products and α-dicarbonyl compounds during incubation were quantified, both quantities produced at each temperature also increased with an increase of time of incubation, and their trends of changes at both temperatures were similar. In practical application for the detection and screening of the antiglycative phytochemicals, each of 20 peanut root extracts was introduced to a series of BSA-fructose solutions and incubated at 37 and 50 °C for 168 and 24 h, correspondingly. All extracts exhibited notable activities and varied depending on peanut origins. Pair comparison of the resultant antiglycative activities determined at 37 and 50 °C showed that both determined activities for each peanut root extract deviated limitedly. As further analyzed, SDS-PAGE-detected glycated BSA quantities formed at 50 °C were closely proportional to the antiglycative activities determined on the basis of their fluorescence intensities. It is of merit to demonstrate that fluorescence-based determination of BSA-fructose reactant after incubation at 50 °C for 24 h is practical and time-saving in the detection and screening of antiglycative phytochemicals.

Wu H.-Y.,National Chiayi University
Evaluation and Program Planning | Year: 2012

This study presents a structural evaluation methodology to link key performance indicators (KPIs) into a strategy map of the balanced scorecard (BSC) for banking institutions. Corresponding with the four BSC perspectives (finance, customer, internal business process, and learning and growth), the most important evaluation indicators of banking performance are synthesized from the relevant literature and screened by a committee of experts. The Decision Making Trial and Evaluation Laboratory (DEMATEL) method, a multiple criteria analysis tool, is then employed to determine the causal relationships between the KPIs, to identify the critical central and influential factors, and to establish a visualized strategy map with logical links to improve banking performance. An empirical application is provided as an example. According to the expert evaluations, the three most essential KPIs for banking performance are customer satisfaction, sales performance, and customer retention rate. The DEMATEL results demonstrate a clear road map to assist management in prioritizing the performance indicators and in focusing attention on the strategy-related activities of the crucial indicators. According to the constructed strategy map, management could better invest limited resources in the areas that need improvement most. Although these strategy maps of the BSC are not universal, the research results show that the presented approach is an objective and feasible way to construct strategy maps more justifiably. The proposed framework can be applicable to institutions in other industries as well. © 2011 Elsevier Ltd.

This study employs a flexible regime-switching EGARCH model with Student-t distributed error terms to investigate whether volatility regimes and basis affect the behavior of crude oil futures returns, including the conditional mean, variance, skewness, kurtosis as well as the extent of heavy-tailedness. The study also examines whether volatility regimes and asymmetric basis effects can improve the forecasting accuracy. The main merit of the empirical model is that the basis effect is allowed to be asymmetric and to vary across volatility regimes. Empirical results suggest that the conditional mean and variance respond to the basis asymmetrically and nonlinearly, and that the responses of transition probabilities to the basis are symmetric. Furthermore, the conditional higher moments are sensitive to the absolute value of basis, and the heavy tailed characteristic can be greatly alleviated by taking into account the asymmetric basis effects and regime switches. Finally, the regime switches and asymmetric basis effects play decisive roles in forecasting return, volatility and tail distribution. © 2011 Elsevier B.V.

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