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Djounova J.,National Center Radiobiology and Radiation Protection | Guleva I.,National Center Radiobiology and Radiation Protection | Negoicheva K.,National Center Radiobiology and Radiation Protection | Mileva I.,National Center Radiobiology and Radiation Protection | And 3 more authors.
Radiation Protection Dosimetry | Year: 2012

A severe radiation accident occurred on Tuesday, 14 June 2011 in an industrial irradiation facility. Five people were exposed for 5-10 min to . 60Co source (137 TBq-3710 Ci). This accident was the first one in Bulgaria, in which the whole-body irradiation doses exceeded 1 Gy and suggested the development of acute radiation syndrome (ARS). This report discusses the diagnostic features of ARS and the use of the METREPOL concept and its diagnostic criteria in assessing the severity of radiation damage. The results used in this study show that injury assessment based only on prodromal symptoms is burdened with a serious error. The probable reasons are at least two: one is the unwillingness of victims to be diagnosed as involved in radiation emergency, which could reflect on their working status, and the other is the slight manifestation of symptoms due to the specific geometry of irradiation. The European Guideline for Medical Management of ARS is a good basis for an early diagnosis of radiation injury. © World Health Organization 2012. All rights reserved.

Gyuleva I.M.,National Center Radiobiology and Radiation Protection | Penkova K.I.,Aleksandrovska Hospital | Rupova I.T.,National Center Radiobiology and Radiation Protection | Panova D.Y.,National Center Radiobiology and Radiation Protection | Djounova J.N.,National Center Radiobiology and Radiation Protection
Dose-Response | Year: 2015

A 10-year survey of immune status of nuclear power plant (NPP) workers was assessed by cellular and humoral immune parameters. The cumulative doses of NPP workers were in the range of 0.06 to 766.36 mSv. The results did not show significant deviations in the studied parameters of cellular and humoral immunity, but a tendency of elevated values in CD3+4+ helper inducers cells, especially its CD4+62L+ subpopulation, regulatory CD4+25+ cells, CD8+28+ cytotoxic subpopulation, and immunoglobulin M, was established. The observed trend of the above-mentioned parameters could be interpreted by assumption that while the adaptation processes are dominated with low prevalence of T-helper (Th) 1 immune response to cumulative doses less than 100 mSv, a switch to Th-2 response occurred at doses above 100 mSv. The impact of a number of other confounding factors on the immune system does not allow definitive conclusions about the direct radiation-induced changes in immune parameters. © The Author(s) 2015.

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