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Makboul M.A.,Assiut University | Attia A.A.,Assiut University | Farag S.F.,Assiut University | Mohamed N.M.,Assiut University | And 4 more authors.
Natural Product Research | Year: 2013

A new pentacyclic triterpenoid, 3β,25-epoxy-3α,22β, 23α-trihydroxy-olean-12-en-28-oic acid (1), together with seven known compounds, including five triterpenoids, β-amyrin (2), lantadene B (3), lantanilic acid (4), lantanolic acid (5) and ursolic acid (6) in addition to β-sitosterol (7) and benzoic acid (8) has been isolated from the leaves of Lantana montevidensis. Their chemical structures were elucidated by spectroscopic analysis and by comparison with the literature data and/or authentic samples. Compound 1 showed moderate to weak antibacterial activity against Staphylococcus aureus and Escherichia coli. © 2013 © 2013 Taylor & Francis.

ElSohly M.A.,Elsohly Laboratories, Inc. | ElSohly M.A.,PSI Inc. | ElSohly M.A.,National Center for Natural Products Research | ElSohly M.A.,University of Mississippi | And 14 more authors.
Journal of Analytical Toxicology | Year: 2012

Methylhexaneamine (MHA) has been marketed in dietary supplements based on arguments that it is a constituent of geranium (Pelargonium graveolens) leaves, stems, roots or oil, and therefore qualifies as a dietary ingredient. The purpose of this study is to determine whether P. graveolens plant material (authenticated) or its oil contains detectable quantities of MHA. Two analytical methods were developed for the analysis of MHA in P. graveolens using gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry. The results were further confirmed using liquid chromatography-high-resolution mass spectrometry. Twenty commercial volatile oils, three authenticated volatile oils and authenticated P. graveolens leaves and stems (young and mature, and fresh and dried) were analyzed for MHA content. In addition, three dietary supplements containing MHA that alleged P. graveolens as the source are analyzed for their MHA content. The data show that none of the authenticated P. graveolens essential oils or plant material, nor any commercial volatile oil of Pelargonium (geranium oil) contain MHA at detectable levels (limit of detection: 10 ppb). The dietary supplements that contained MHA as one of their ingredients (allegedly from geranium or geranium stems) contained large amounts of MHA. The amounts of MHA measured are incompatible with the use of reasonable amounts of P. graveolens extract or concentrate, suggesting that MHA was of synthetic origin. © The Author [2012]. Published by Oxford University Press. All rights reserved.

Kutrzeba L.M.,University of Mississippi | Li X.-C.,National Center for Natural Products Research | Ding Y.,National Center for Natural Products Research | Ferreira D.,University of Mississippi | And 3 more authors.
Journal of Natural Products | Year: 2010

Extraction of fresh Salvia divinorum leaves afforded salvinorins E and D as potential biosynthesis precursors of salvinorin A, a major metabolite and a potent hallucinogen. Attempts at HPLC purification of salvinorin E (2) with acetonitrile as a solvent revealed an equilibrium with its regioisomer, salvinorin D (3), in a 3:5 ratio. The presence of both compounds was readily observed in the 1H NMR spectrum. This spontaneous formation of the mixture of isomers occurs via a dynamic intramolecular transacetylation process. © 2010 The American Chemical Society and American Society of Pharmacognosy.

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