National Center for Nanosciences and Technology of China
National Center for Nanosciences, Technology of China and Chinese Academy of Sciences | Date: 2017-05-31
The present invention provides a group of polypeptides and a complex formed by the polypeptides and human serum albumin, a method for improving the solubility of the group of polypeptides in a salt solution by combining the polypeptides with human serum albumin, a method for preparing the complex formed by the group of polypeptides and human serum albumin, and an application of the group of polypeptides and the complex formed by the polypeptides and human serum albumin in the preparation of drugs for suppressing tumor metastasis and treating leukemia.
Fang Z.,Peking University |
Zhu X.,National Center for Nanosciences and Technology of China
Advanced Materials | Year: 2013
Plasmonics has developed into one of the rapidly growing research topics for nanophotonics. With advanced nanofabrication techniques, a broad variety of nanostructures can be designed and fabricated for plasmonic devices at nanoscale. Fundamental properties for both surface plasmon polaritons (SPP) and localized surface plasmons (LSP) arise a new insight and understanding for the electro-optical device investigations, such as plasmonic nanofocusing, low-loss plasmon waveguide and active plasmonic detectors for energy harvesting. Here, we review some typical functional plasmonic nanostructures and nanosmart devices emerging from our individual and collaborative research works. Plasmonics has developed into one of the rapidly growing research topics for nanophotonics. With advanced nanofabrication techniques, a broad variety of plasmonic nanostructures have been designed and fabricated. Combining the merits of both surface plasmons and graphene, the graphene photodetection can be greatly enhanced, leading to a new research area as graphene plasmonics. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMBP-26-2016 | Award Amount: 10.76M | Year: 2016
An increasing number of nanomaterials (NMs) are entering the market in every day products spanning from health care and leisure to electronics, cosmetics and foodstuff. Nanotechnology is a truly enabling technology, with unlimited potential for innovation. However, the novelty in properties and forms of NMs makes the development of a well-founded and robust legislative framework to ensure safe development of nano-enabled products particularly challenging. At the heart of the challenge lies the difficulty in the reliable and reproducible characterisation of NMs given their extreme diversity and dynamic nature, particularly in complex environments, such as within different biological, environmental and technological compartments. Two key steps can resolve this: 1) the development of a holistic framework for reproducible NM characterisation, spanning from initial needs assessment through method selection to data interpretation and storage; and 2) the embedding of this framework in an operational, linked-up ontological regime to allow identification of causal relationships between NMs properties, be they intrinsic, extrinsic or calculated, and biological, (eco)toxicological and health impacts fully embedded in a mechanistic risk assessment framework. ACEnano was conceived in response to the NMBP 26 call with the aim to comprehensively address these two steps. More specifically ACEnano will introduce confidence, adaptability and clarity into NM risk assessment by developing a widely implementable and robust tiered approach to NM physico-chemical characterisation that will simplify and facilitate contextual (hazard or exposure) description and its transcription into a reliable NMs grouping framework. This will be achieved by the creation of a conceptual toolbox that will facilitate decision-making in choice of techniques and SOPs, linked to a characterisation ontology framework for grouping and risk assessment and a supporting data management system.
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2010-1.3-1 | Award Amount: 12.48M | Year: 2011
While there are standard procedures for product life cycle analysis, exposure, hazard, and risk assessment for traditional chemicals, is not yet clear how these procedures need to be modified to address all the novel properties of nanomaterials. There is a need to develop specific reference methods for all the main steps in managing the potential risk of ENM. The aim of MARINA is to develop such methods. MARINA will address the four central themes in the risk management paradigm for ENM: Materials, Exposure, Hazard and Risk. The methods developed by MARINA will be (i) based on beyond-state-of-the-art understanding of the properties, interaction and fate of ENM in relation to human health and the quality of the environment and will either (ii) be newly developed or adapted from existing ones but ultimately, they will be compared/validated and harmonised/standardised as reference methods for managing the risk of ENM. MARINA will develop a strategy for Risk Management including monitoring systems and measures for minimising massive exposure via explosion or environmental spillage.
Liu Y.,National Center for Nanosciences and Technology of China |
Zhao Y.,National Center for Nanosciences and Technology of China |
Zhao Y.,CAS Institute of High Energy Physics |
Sun B.,CAS Institute of High Energy Physics |
Chen C.,National Center for Nanosciences and Technology of China
Accounts of Chemical Research | Year: 2013
Because of their unique physical, chemical, electrical, and mechanical properties, carbon nanotubes (CNTs) have attracted a great deal of research interest and have many potential applications. As large-scale production and application of CNTs increases, the general population is more likely to be exposed to CNTs either directly or indirectly, which has prompted considerable attention about human health and safety issues related to CNTs. Although considerable experimental data related to CNT toxicity at the molecular, cellular, and whole animal levels have been published, the results are often conflicting. Therefore, a systematic understanding of CNT toxicity is needed but has not yet been developed.In this Account, we highlight recent investigations into the basis of CNT toxicity carried out by our team and by other laboratories. We focus on several important factors that explain the disparities in the experimental results of nanotoxicity, such as impurities, amorphous carbon, surface charge, shape, length, agglomeration, and layer numbers. The exposure routes, including inhalation, intravenous injection, or dermal or oral exposure, can also influence the in vivo behavior and fate of CNTs. The underlying mechanisms of CNT toxicity include oxidative stress, inflammatory responses, malignant transformation, DNA damage and mutation (errors in chromosome number as well as disruption of the mitotic spindle), the formation of granulomas, and interstitial fibrosis. These findings provide useful insights for de novo design and safe application of carbon nanotubes and their risk assessment to human health.To obtain reproducible and accurate results, researchers must establish standards and reliable detection methods, use standard CNT samples as a reference control, and study the impact of various factors systematically. In addition, researchers need to examine multiple types of CNTs, different cell lines and animal species, multidimensional evaluation methods, and exposure conditions. To make results comparable among different institutions and countries, researchers need to standardize choices in toxicity testing such as that of cell line, animal species, and exposure conditions. The knowledge presented here should lead to a better understanding of the key factors that can influence CNT toxicity so that their unwanted toxicity might be avoided. © 2012 American Chemical Society.
Xue X.,National Center for Nanosciences and Technology of China
Nature Nanotechnology | Year: 2016
Methamphetamine (METH) abuse is a serious social and health problem worldwide. At present, there are no effective medications to treat METH addiction. Here, we report that aggregated single-walled carbon nanotubes (aSWNTs) significantly inhibited METH self-administration, METH-induced conditioned place preference and METH- or cue-induced relapse to drug-seeking behaviour in mice. The use of aSWNTs alone did not significantly alter the mesolimbic dopamine system, whereas pretreatment with aSWNTs attenuated METH-induced increases in extracellular dopamine in the ventral striatum. Electrochemical assays suggest that aSWNTs facilitated dopamine oxidation. In addition, aSWNTs attenuated METH-induced increases in tyrosine hydroxylase or synaptic protein expression. These findings suggest that aSWNTs may have therapeutic effects for treatment of METH addiction by oxidation of METH-enhanced extracellular dopamine in the striatum. © 2016 Nature Publishing Group
National Center for Nanosciences and Technology of China | Date: 2013-02-04
The present invention provides a preparation method of an antigen composition. The preparation method comprises the following steps: (1) obtaining a tumor antigen protein; (2) making the tumor antigen protein into contact with an immature dendritic cell; (3) inducing the immature dendritic cell in contact with the tumor antigen into a mature dendritic cell; and (4) separating a cell vesicle of the mature dendritic cell. The present invention further provides an antigen composition obtained through the preparation method and the application thereof in preparing a tumor vaccine.
National Center for Nanosciences, Technology of China and Beijing Entry Exit Inspection And Quarantine Burea Peoples Republic Of China | Date: 2014-02-05
The present invention provides a detection method of nucleic acid. The character of the method is that the method comprises the following steps: providing nucleic acid to be tested, in asymmetric PCR reaction conditions, making the nucleic acid to be tested react with a pair of primers that enable the target nucleic acid amplification, DNA polymerase, adenine deoxyribonucleotide, guanine deoxyribonucleotide, cytosine deoxyribonucleotide and thymidine deoxyribonucleotide in the PCR buffer solution, mixing the product of the reaction and the liquid that contains probe molecules, and judging whether the nucleic acid to be tested contains the target nucleic acid or not by observing the color or the color change of the obtained mixture. The present invention also provides a kit that can be used in the nucleic acid detection by the said method and the application of the method and the kit in inspection and quarantine. The method of the present invention is a quick and easy, sensitive and specific detection method of nucleic acid with direct observation using naked eyes, and the method does not need additional equipment.
National Center for Nanosciences and Technology of China | Date: 2012-06-01
A method for detecting hepcidin. Having a sample liquid in contact with a nanochip having a specific surface coating structure of silicon oxide, so that hepcidin is enriched with specificity; eluting the nanochip with an eluent; by performing mass spectrometric detection on the elution product, determining the hepcidin content in the elution product. The enrichment method substantially enhances the sensitivity and accuracy of mass spectrometric detection. A kit for detecting hepcidin comprising a sample diluent and a nanochip, the sample diluent comprising water, trifluoroacetic acid, and acetonitrile.
National Center for Nanosciences and Technology of China | Date: 2012-07-27
Provided is a method for treating single-walled carbon nanotube, comprising: (1) allowing single-walled carbon nanotubes to contact with a surfactant and a dispersant sequentially in the present of a solvent, to obtain highly dispersed single-walled carbon nanotubes in which the content of single dispersed single-walled carbon nanotubes is not lower than 50 wt %, wherein, the single-walled carbon nanotubes can be dispersed in the solvent, and the surfactant and dispersant can be dissolved in the solvent; (2) employing density gradient centrifugation to sort the highly dispersed single-walled carbon nanotubes obtained in step (1). This method can effectively separate single-walled carbon nanotubes with different structural properties.