San Ignacio de Hidalgo, Mexico
San Ignacio de Hidalgo, Mexico

Time filter

Source Type

Laura Gabriela C.-B.,National Cardiology Institute Ignacio Chavez | Laura Gabriela C.-B.,Childrens Hospital of Mexico Federico Gomez | Nalleli V.-M.,Childrens Hospital of Mexico Federico Gomez | Dalia Patricia A.-T.,Mexican Committee for the Prevention of Osteoporosis | And 4 more authors.
Journal of Clinical Densitometry | Year: 2012

The aim of this study was to evaluate bone quality and nutritional status in children with congenital heart defects (CHDs) using quantitative ultrasound. A cross-sectional study was designed. A population-based sample of 75 children with CHD (age: 0-6yr) from the Department of Pediatric Cardiology at the National Cardiology Institute " Ignacio Chávez" was compared with 106 healthy children during 2009. Weight and height were determined in both groups; bone status was measured at the radius and tibia as speed of sound (SOS). Nutritional status was defined according to the Waterloo and Gómez index. Chi-square test, Student's t-test, and analysis of variance were used to determine the statistical differences. A linear regression analysis adjusted by age, weight, height, type of CHD, and birth weight was made. Both groups were similar in sex distribution, prematurity, and birth weight. Acyanotic cardiopathy with increased pulmonary flow was the most frequent (61.3%). Prevalence of malnutrition was higher in CHD group compared with healthy children (p<0.001), and radius SOS was lower in children with CHD compared with healthy children (3484±180 vs 3575±159m/s, respectively; 95% confidence interval: 39.8-143; p=0.001). A positive correlation was found between CHD and reduced SOS in the adjusted linear regression model, r 2=0.455 (p<0.001). Children with CHD have lower SOS radius values compared with healthy children, suggesting reduced bone quality regardless of the nutritional status. © 2012 The International Society for Clinical Densitometry.


Al Maluli H.,Temple University | DeStephan C.M.,Temple University | Alvarez R.J.,Temple University | Sandoval J.,National Cardiology Institute Ignacio Chavez
Clinical Cardiology | Year: 2015

Pulmonary arterial hypertension (PAH) is a rare disease, but it boasts significant morbidity and mortality. Although remarkable achievements have been made in the medical treatment of PAH, there is a role for invasive or surgical procedures in patients with progressive disease despite optimal medical therapy or with no access to such therapy. Atrial septostomy creates a right-to-left intracardiac shunt to decompress the overloaded right ventricle. Despite significant advances to validate and improve this palliative procedure, as well as recent reports of improved outcomes, it is only slowly being adopted. This article aims to detail the history, indications, contraindications, procedural techniques, and outcomes of atrial septostomy. We will also shed light on some of the newer interventions, inspired by the same physiological concept, that are being evaluated as potential palliative modalities in patients with PAH. © 2015 Wiley Periodicals, Inc.


Avila-Vanzzini N.,National Cardiology Institute Ignacio Chavez | Posadas-Romero C.,National Cardiology Institute Ignacio Chavez | Del Carmen Gonzalez-Salazar M.,National Cardiology Institute Ignacio Chavez | Maass-Iturbide C.,National Cardiology Institute Ignacio Chavez | And 7 more authors.
Archivos de Cardiologia de Mexico | Year: 2015

The I/D insertion/deletion polymorphism of the angiotensin-converting enzyme has been related to hypertension. This polymorphism also seems to have gender related implications. Angiotensin II contributes to the production and release of oxygen reactive species that react with nitric oxide, inactivating its effects. Objective: To establish whether the ACE I/D polymorphism correlates with nitric oxide plasma metabolites in healthy men and women. Methods: Among 896 subjects between 18 and 30 years of age range, 138 fulfilled inclusion criteria. The polymorphism was identified by polymerase chain reaction, and blood nitric oxide metabolites were analyzed following the method described by Bryan. Results: Both systolic and diastolic arterial pressures were higher in men than in women (107/67 vs. 101/65 mmHg, p < 0.001). In terms of the ACE gene, there were differences in the concentration of nitric oxide metabolites in men with the I/D and D/D genotypes when compared to carriers of the I/I genotype (33.55 and 29.23 vs. 53.74 pmol/ml; p = <0.05), while there were no significant differences in women when compared by genotype. Men with the D/D genotype had higher systolic blood pressure than I/D carriers (111 vs. 104 mmHg, p < 0.05). We observed no arterial blood pressure differences in women when grouped by ACE genotype. Conclusions: The ACE D/D genotype was associated with nitric oxide metabolite levels and systolic blood pressure in clinically healthy men while it had no effect in women. © 2013 Instituto Nacional de Cardiología Ignacio Chávez. Published by Masson Doyma México S.A. All rights reserved.


Vivanco-Munoz N.,Childrens Hospital of Mexico | Talavera J.O.,Hospital Of Especialidades Cmn Sxxi | Juanico-Enriquez A.,National Cardiology Institute Ignacio Chavez | Clark P.,Childrens Hospital of Mexico
Journal of Pediatric Infectious Diseases | Year: 2010

Nosocomial infections at pediatric intensive care units (PICUs) often lead to substantial morbidity, mortality, and prolonged hospital stays in children who have open-heart surgery. Little is known about the risk factors in this population. Our aim was to identify the incidence and clinical factors associated with infections at the PICU in children with congenital heart disease after surgery. Clinical records of patients ≤ 3-year-old with congenital heart disease, admitted for surgery, were evaluated for clinical, nutritional, and other risk factors. Infection was determined during the patient's stay at the PICU. Two hundred eighty-nine patients were included in the study. Factors related to overall infection were: higher risk adjustment for congenital heart surgery, age > 1-year-old, cyanotic cardiac anomaly, parenteral or mixed nutrition support, more than 5 days of fasting, and mechanical ventilation ≥ 48. Factors related to pneumonia were higher risk adjustment for congenital heart surgery, cyanotic cardiac anomaly more than three inotropics infused during surgery, parenteral or mixed nutritional support, more than 5 days of fasting, and mechanical ventilation ≥ 48 h. Factors related to mediastinitis and sepsis were: age > 1-year-old, aortic clamp ≥ 120 min, parenteral or mixed nutritional support, more than 5 days of fasting, and mechanical ventilation ≥ 48 h. In the multivariate survival analysis, parenteral or mixed nutrition and mechanical ventilation ≥ 48 h increased the risk for overall infection (relative risk 1.949, 95% confidence interval 1.108-3.43, P=0.021 and relative risk 25, 95% confidence interval 2.53-246.19, P =0.006 respectively). Early enteral nutrition after surgery and early weaning from mechanical ventilation (less than 48 h) will reduce infection incidence. © 2010 IOS Press and the authors. All rights reserved.


Lopez M.E.S.,National Cardiology Institute Ignacio Chavez | Avila R.G.,National Cardiology Institute Ignacio Chavez | Hernandez E.,National Cardiology Institute Ignacio Chavez | Huesca-Gomez C.,National Cardiology Institute Ignacio Chavez | And 6 more authors.
Journal of Interferon and Cytokine Research | Year: 2013

Takayasu's arteritis (TA) is a chronic inflammatory arteritis of unknown etiology involving mainly the aorta and its major branches. The interleukin (IL) 1β and IL-1 receptor antagonist have been playing an important role as regulators of inflammation. We investigated whether the polymorphisms at the IL-1B and IL-1RN gene cluster were associated with the genetic susceptibility to develop TA. We analyzed the IL-1B, IL-1F10.3, and IL-1RN polymorphisms in a sample of 58 TA patients, and 248 clinically healthy unrelated Mexican individuals by 5′ exonuclease TaqMan polymerase chain reaction. Polymorphic haplotypes were constructed after linkage disequilibrium analysis. We found increased frequencies of different polymorphisms (C allele and TC genotype of IL-1F10.3; TT genotype of IL-1RN.4; C allele and TC genotype of IL-1RN6.1; G allele of IL-1RN6.2 and haplotypes 1T and 1C of IL-RN VNTR and IL-1RN6.1) in the group of TA when compared to healthy controls. On the other hand, decreased frequency of IL-1-511 TC genotype was found in the TA group compared to controls. IL-1B and IL-1RN gene polymorphisms could be involved in the risk of developing TA in the Mexican population. These associations were independent of the affected vessels. © 2013, Mary Ann Liebert, Inc.


PubMed | National Cardiology Institute Ignacio Chavez and Temple University
Type: Journal Article | Journal: Clinical cardiology | Year: 2015

Pulmonary arterial hypertension (PAH) is a rare disease, but it boasts significant morbidity and mortality. Although remarkable achievements have been made in the medical treatment of PAH, there is a role for invasive or surgical procedures in patients with progressive disease despite optimal medical therapy or with no access to such therapy. Atrial septostomy creates a right-to-left intracardiac shunt to decompress the overloaded right ventricle. Despite significant advances to validate and improve this palliative procedure, as well as recent reports of improved outcomes, it is only slowly being adopted. This article aims to detail the history, indications, contraindications, procedural techniques, and outcomes of atrial septostomy. We will also shed light on some of the newer interventions, inspired by the same physiological concept, that are being evaluated as potential palliative modalities in patients with PAH.


PubMed | National Cardiology Institute Ignacio Chavez, Medica Sur Clinical Foundation and National Cardiology Institute
Type: Journal Article | Journal: Archivos de cardiologia de Mexico | Year: 2015

The I/D insertion/deletion polymorphism of the angiotensin-converting enzyme has been related to hypertension. This polymorphism also seems to have gender related implications. Angiotensin II contributes to the production and release of oxygen reactive species that react with nitric oxide, inactivating its effects.To establish whether the ACE I/D polymorphism correlates with nitric oxide plasma metabolites in healthy men and women.Among 896 subjects between 18 and 30 years of age range, 138 fulfilled inclusion criteria. The polymorphism was identified by polymerase chain reaction, and blood nitric oxide metabolites were analyzed following the method described by Bryan.Both systolic and diastolic arterial pressures were higher in men than in women (107/67 vs. 101/65 mm Hg, p<0.001). In terms of the ACE gene, there were differences in the concentration of nitric oxide metabolites in men with the I/D and D/D genotypes when compared to carriers of the I/I genotype (33.55 and 29.23 vs. 53.74 pmol/ml; p=<0.05), while there were no significant differences in women when compared by genotype. Men with the D/D genotype had higher systolic blood pressure than I/D carriers (111 vs. 104 mm Hg, p<0.05). We observed no arterial blood pressure differences in women when grouped by ACE genotype.The ACE D/D genotype was associated with nitric oxide metabolite levels and systolic blood pressure in clinically healthy men while it had no effect in women.


PubMed | CINVESTAV and National Cardiology Institute Ignacio Chavez
Type: | Journal: Oxidative medicine and cellular longevity | Year: 2016

Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohns disease (CD) are multifactorial, relapsing disorders of the gastrointestinal tract. However, the etiology is still poorly understood but involves altered immune responses, epithelial dysfunction, environmental factors, and nutrition. Recently, we have shown that the diet supplement corabion has cardioprotective effects due to reduction of oxidative stress and inflammation. Since oxidative stress and inflammation are also prominent risk factors in IBD, we speculated that corabion also has beneficial effects on experimental colitis. Colitis was induced in male mice by administration of 3.5%(w/v) dextran sulfate sodium (DSS) in drinking water for a period of 3 or 7 days with or without daily gavage feeding of corabion consisting of vitamin C, vitamin E, L-arginine, and eicosapentaenoic and docosahexaenoic acid. We found that corabion administration attenuated DSS-induced colon shortening, tissue damage, and disease activity index during the onset of colitis. Mechanistically, these effects could be explained by reduced neutrophil recruitment, oxidative stress, production of proinflammatory cytokines, and internalization of the junctional proteins ZO-1 and E-cadherin leading to less edema formation. Thus, corabion may be a useful diet supplement for the management of chronic inflammatory intestinal disorders such as IBD.


PubMed | National Cardiology Institute Ignacio Chavez
Type: Journal Article | Journal: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry | Year: 2012

The aim of this study was to evaluate bone quality and nutritional status in children with congenital heart defects (CHDs) using quantitative ultrasound. A cross-sectional study was designed. A population-based sample of 75 children with CHD (age: 0--6yr) from the Department of Pediatric Cardiology at the National Cardiology Institute Ignacio Chvez was compared with 106 healthy children during 2009. Weight and height were determined in both groups; bone status was measured at the radius and tibia as speed of sound (SOS). Nutritional status was defined according to the Waterloo and Gmez index. Chi-square test, Students t-test, and analysis of variance were used to determine the statistical differences. A linear regression analysis adjusted by age, weight, height, type of CHD, and birth weight was made. Both groups were similar in sex distribution, prematurity, and birth weight. Acyanotic cardiopathy with increased pulmonary flow was the most frequent (61.3%). Prevalence of malnutrition was higher in CHD group compared with healthy children (p<0.001), and radius SOS was lower in children with CHD compared with healthy children (3484180 vs 3575159m/s, respectively; 95% confidence interval: 39.8--143; p=0.001). A positive correlation was found between CHD and reduced SOS in the adjusted linear regression model, r=0.455 (p<0.001). Children with CHD have lower SOS radius values compared with healthy children, suggesting reduced bone quality regardless of the nutritional status.

Loading National Cardiology Institute Ignacio Chavez collaborators
Loading National Cardiology Institute Ignacio Chavez collaborators