National Cancer Institute INCan

Mexico City, Mexico

National Cancer Institute INCan

Mexico City, Mexico
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Granados Garcia M.,National Cancer Institute of Mexico INCan | Chilaca Rosas M.F.,National Cancer Institute of Mexico INCan | Lavin Lozano A.J.,National Cancer Institute of Mexico INCan | Maldonado Magos F.,National Cancer Institute of Mexico INCan | And 6 more authors.
Clinical and Translational Oncology | Year: 2011

Purpose: To explore the response and toxicity of advanced non-metastatic squamous cell carcinomas of upper aerodigestive tract (SCC-UADT) to a combination of cetuximab concomitant with gemcitabine and radiotherapy. Methods: We managed patients with concomitant treatment of cetuximab (400 mg/m 2 as uploading dose, then 250 mg/m2, IV) concomitant with gemcitabine (50 mg/m2) weekly for seven courses, and radiotherapy in classical fractionation until completion of 70 Gy. Primary endpoints were complete response (CR) to treatment and toxicity. We evaluated patients for toxicity on a weekly basis; evaluation of response included physical examination, endoscopy, computed tomography (CT) scan and biopsy when indicated, and was performed 6 weeks after completion of radiotherapy. Additional evaluations were done every 3 months to document disease status. Between November 2004 and November 2005, 20 patients were included. Results: CR was 82.4%, overall response was 100%. Neck disease reached CR in 61.5% and partial in 38.5% of patients. The main toxicities were nausea, lymphopenia, neutropenia and mucositis. Grade 3 and 4 side effects were presented in 70.6% of patients, but mucositis, and lymphopenia without clinical repercussions, occurred in 88.2% of patients. Gastrostomy was required in 11.8% of patients to maintain nutrition. Radioepithelitis developed in 76.5%, but only three of these (23.1%) were grade III. Median overall survival was 53 months (range 6-55 months) and median progression-free survival has not yet been reached at the time of evaluation. Conclusions: Although toxicity is important, this approach has interesting activity and deserves further investigation.

Campillo-Navarro M.,Polytechnic School of Algiers | Chavez-Blanco A.D.,National Cancer Institute INCAN | Wong-Baeza I.,Polytechnic School of Algiers | Serafin-Lopez J.,Polytechnic School of Algiers | And 4 more authors.
Current Respiratory Medicine Reviews | Year: 2014

Lungs are indispensable organs for the respiratory process, and maintaining their homeostasis is essential for human health and survival. However, during the lifetime of an individual, the lungs suffer countless insults that put at risk their delicate organization and function. Many cells of the immune system participate to maintain this equilibrium and to keep functional lungs. Among these cells, mast cells have recently attracted attention because of their ability to rapidly secrete many chemical and biological mediators that modulate different processes like inflammation, angiogenesis, cell proliferation, etc. In this review, we focus on recent advances in the understanding of the role that mast cells play in lung protection during infections, and of the relation of mast cell responses to type I hypersensitivity-associated pathologies. Furthermore, we discuss the potential role of mast cells during wound healing in the lung and its association with lung cancer, and how mast cells could be exploited as therapeutic targets in some diseases © 2014 Bentham Science Publishers.

Lara-Medina F.,National Cancer Institute INCan | Lara-Medina F.,Instituto Nacional Of Cancerologia | Perez-Sanchez V.,INCan | Saavedra-Perez D.,Laboratory of Experimental Oncology | And 14 more authors.
Cancer | Year: 2011

BACKGROUND: Triple-negative breast cancer (TNBC) is defined as breast cancer that is negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. TNBC represents 15% of all invasive breast cancers, but some studies have suggested that its prevalence differs between races. To the authors' knowledge, no previous studies have determined the prevalence of TNBC and its risk factors among Hispanic women. METHODS: The authors identified 2074 Hispanic women with breast cancer who attended the National Cancer Institute in Mexico City from 1998 to 2008. All histopathologic and immunohistochemical diagnoses were rereviewed by a breast cancer pathologist. The prevalence of TNBC, its association with clinicopathologic characteristics, and its prognostic impact were determined. RESULTS: The median patient age at diagnosis (±standard deviation) was 50 ± 12 years. The overall prevalence of TNBC was 23.1%. Younger age (P <.001), premenopausal status (P =.002), increased parity (P =.029), hormonal contraceptive use (P =.04) high histologic grade (P <.001), and advanced disease (P <.001) were associated independently with TNBC. Postmenopausal patients who had a body mass index (BMI) <25 kg/m2 (P =.027) or <30 kg/m2 (P <.001) were more likely to have TNBC. In multivariate analysis, patients with TNBC had a higher risk of locoregional recurrence (LRR), lower disease-free survival (DFS) (hazard ratio, 1.62; 95% confidence interval, 1.13-2.32; P =.009), and a lower cancer-specific survival (CSS) rate (hazard ratio, 1.66; 95% confidence interval, 1.20-2.30; P =.002) than patients with non-TNBC. CONCLUSIONS: The median age at diagnosis of Hispanic women with breast cancer was 11 years younger than the average age reported in the United States. The prevalence of TNBC in this study population was higher than that reported in white women with breast cancer. TNBC was associated with a higher risk of LRR and with lower DFS and CSS than those in patients with non-TNBC. © 2011 American Cancer Society.

Arrieta O.,National Cancer Institute INCan | Cardona A.F.,Santa Fe Institute | Cardona A.F.,Foundation for Clinical and Applied Cancer Research FICMAC | Corrales L.,Hospital San Juan Of Dios Ccss | And 13 more authors.
Lung Cancer | Year: 2015

Objectives: In non-small cell lung cancer (NSCLC), the association between common EGFR mutations (Del EX19/L858R) with EGFR tyrosine kinase inhibitors (EGFR-TKIs) has been well established. However, this has not been investigated for rare EGFR mutations or their impact on treatment response and outcome to EGFR TKIs (primary objective) and chemotherapy (secondary objective). Materials and methods: In an observational prospective cohort, we analyzed 188 NSCLC patients from Mexico, Colombia and Costa Rica with EGFR mutations. As a first line of treatment, 66.5% received platinum-based chemotherapy. All patients received TKIs in first-line treatment or after progression to chemotherapy. The clinical-pathological characteristics as well as the f of common and rare EGFR mutations associated with treatment response were analyzed. Results: Of all patients, 79.5% had common and 20.5% had rare EGFR mutations. Lepidic and acinar adenocarcinomas were associated with common EGFR mutations (p=. 0.010). Patients with common EGFR mutations had higher response rates to EGFR-TKIs than those who had rare EGFR mutations (63.8 vs 32.4%, p<. 0.001). Women had increased progression-free survival (PFS) to EGFR-TKIs than men (16.4 vs 9.5 months, p=. 0.02). The median PFS and overall survival (OS) were better in patients with common EGFR mutations (15.5 vs 3.9 months, p<. 0.001; and 37.3 vs 17.4 months, p<. 0.001) respectively. Conclusion: Our findings suggested that only patients with rare EGFR mutations could receive platinum-based chemotherapy as a first-line treatment, due to their low response rates and short PFS in response to EGFR-TKIs. Consequently, EGFR-TKIs could be reserved as a second- or third-line treatment. In patients with EGFR mutations, women have better PFS to EGFR-TKIs than men, and rare EGFR mutations are more frequent in high grade adenocarcinomas than in low grade tumors. © 2014 Elsevier Ireland Ltd.

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