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Kishore R.K.,National Ayurveda Dietetics Research Institute | Abhishekh H.A.,National Institute of Mental Health and Neuro Sciences | Udupa K.,Toronto Western Hospital | Thirthalli J.,National Institute of Mental Health and Neuro Sciences | And 4 more authors.
Asian Journal of Psychiatry | Year: 2014

Introduction: Ayurveda (Indian-complimentary and alternative medicine) is still most sought after in India and has promising potential in management of Vishada [major depressive disorder (MDD)]. But, systematic research is lacking. In this study we evaluated of influence of ayurvedic treatment (Panchakarma and Ayushman-15) on psychopathology, heart rate variability (HRV) and endocrinal parameters in patients with major depression. Methods: 81 drug naive patients diagnosed as Vishada by ayurvedic physician and MDD according to DSM IV-TR were given ayurvedic Virechana module (therapeutic purgation) and were randomized into two groups. Patients in group A (n= 41) received Ayushman-15A while group B (n= 40) received Ayushman-15B for two months and Shirodhara (forehead-oil pouring therapy). Patients were assessed with Hamilton Depression Rating Scale (HDRS), Montgomery Asberg Depression Rating Scale (MADRS), Heart Rate Variability (HRV). Cortisol and adrenocorticotropic hormone (ACTH) were estimated at baseline and after ayurvedic therapy. HRV and endocrinal parameters were compared with age and gender matched healthy volunteers. Results: HRV parameters showed significant sympathetic dominance in patients compared to healthy volunteers. Two months of ayurvedic treatment significantly decreased psychopathology, showed increase in vagal tone, decrease in sympathetic tone and reduced cortisol levels. However, there was no significant difference between groups receiving Ayushman A and B. Conclusion: This study provides evidence for antidepressant, cardiac (HRV) and beneficial neuroendocrine modulatory influence of Ayurveda therapy in patients of Vishada (MDD). Further studies are needed to confirm these findings. Greater insight into the neurobiology behind this therapy might provide valuable information about newer drug target. © 2014 Elsevier B.V.

Kavya N.,National Ayurveda Dietetics Research Institute | Kavya B.,National Ayurveda Dietetics Research Institute | Ramarao V.,National Ayurveda Dietetics Research Institute | Kishore Kumar R.,National Ayurveda Dietetics Research Institute | Venkateshwarlu G.,National Ayurveda Dietetics Research Institute
International Journal of Research in Ayurveda and Pharmacy | Year: 2014

Mudga or green gram is one of the most commonly used components of Indian cuisine. A majority of the Ayurvedic lexicons opine that it is the best among all pulses and advocate its use in everyday diet. Excerpts from Ayurveda and recent research based studies showcase it as a potential interventional diet in Cardio vascular and lifestyle disorders. This review throws light on some of the important aspects of Mung bean as an effective lifestyle intervention in a wide spectrum of disorders. References from various Samhitas and Nighantus of Ayurveda were collected systematically with respect to Mudga, its properties and actions. Evidence based research studies were also reviewed in this regard and are compiled in this article.

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