National Applied Research Laboratory

Hsinchu, Taiwan

National Applied Research Laboratory

Hsinchu, Taiwan

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Lin K.-M.,National Chiao Tung University | Hu M.-H.,National Chiao Tung University | Hung C.-T.,National Chiao Tung University | Wu J.-S.,National Chiao Tung University | And 3 more authors.
Computer Physics Communications | Year: 2012

Development of a hybrid numerical algorithm which couples weakly with the gas flow model (GFM) and the plasma fluid model (PFM) for simulating an atmospheric-pressure plasma jet (APPJ) and its acceleration by two approaches is presented. The weak coupling between gas flow and discharge is introduced by transferring between the results obtained from the steady-state solution of the GFM and cycle-averaged solution of the PFM respectively. Approaches of reducing the overall runtime include parallel computing of the GFM and the PFM solvers, and employing a temporal multi-scale method (TMSM) for PFM. Parallel computing of both solvers is realized using the domain decomposition method with the message passing interface (MPI) on distributed-memory machines. The TMSM considers only chemical reactions by ignoring the transport terms when integrating temporally the continuity equations of heavy species at each time step, and then the transport terms are restored only at an interval of time marching steps. The total reduction of runtime is 47% by applying the TMSM to the APPJ example presented in this study. Application of the proposed hybrid algorithm is demonstrated by simulating a parallel-plate helium APPJ impinging onto a substrate, which the cycle-averaged properties of the 200th cycle are presented. The distribution patterns of species densities are strongly correlated by the background gas flow pattern, which shows that consideration of gas flow in APPJ simulations is critical. © 2012 Elsevier B.V. All rights reserved.


Hsieh W.-H.,National Chiao Tung University | Hsieh W.-H.,St. Jude Medical | Chang C.-F.,National Applied Research Laboratory | Kao M.-S.,National Chiao Tung University
IEEE Transactions on Aerospace and Electronic Systems | Year: 2014

In this paper, a novel method termed the phase coherence acquisition (PCA) is proposed for pseudorandom (PN) sequence acquisition. By employing complex phasors, the PCA requires only complex additions in the order of N , the length of the sequence, whereas the conventional method using fast Fourier transform (FFT) requires complex multiplications and additions both in the order of N log2N . To combat noise, the input and local sequences are partitioned and mapped into complex phasors in PCA. The phase differences between pairs of input and local phasors are used for acquisition; thus, complex multiplications are avoided. For more noise-robustness capability, the multilayer PCA is developed to extract the code phase step-by-step. The significant reduction of computational loads makes the PCA an attractive method, especially when the sequence length of N is extremely large, which becomes intractable for the FFT-based acquisition. © 2014 IEEE.


Lin Y.-J.,National Taipei University of Technology | Wu Y.-C.,National Taipei University of Technology | Mani V.,National Taipei University of Technology | Huang S.-T.,National Taipei University of Technology | And 3 more authors.
Biosensors and Bioelectronics | Year: 2016

The real-time quantitative electrochemical monitoring of nucleic acid amplification through PCR is a promising renowned methodology to detect pathogenic DNAs. In this work, anthraquinone-pyrrole derivatives based redox intercalating probes (AP probes: AP1, AP2) have been designed, synthesized, characterized and successfully demonstrated in real-time like quantitative PCR. The rationally designed AP probes exhibited excellent DNA binding abilities and electrochemical behaviors. The binding parameters such as binding constant, binding site size and diffusion coefficient were estimated which were comparable to literature reports. Besides, the AP probes are highly stable under PCR thermal conditions and did not inhibit PCR. Therefore, a real-time like quantification of DNA amplification was demonstrated to quantify the initial copy number of target genes. The probe AP2 has excellent ability to detect ~103 copies of target tpc DNA with good sensitivity. The AP probes are metal-free, easily synthesizable, non-toxic, thermally stable and feasible for miniaturized PCR chips. © 2015 Elsevier B.V.


PubMed | National Taipei University of Technology, WinSense Biotech Corporation and National Applied Research Laboratory
Type: | Journal: Biosensors & bioelectronics | Year: 2016

The real-time quantitative electrochemical monitoring of nucleic acid amplification through PCR is a promising renowned methodology to detect pathogenic DNAs. In this work, anthraquinone-pyrrole derivatives based redox intercalating probes (AP probes: AP1, AP2) have been designed, synthesized, characterized and successfully demonstrated in real-time like quantitative PCR. The rationally designed AP probes exhibited excellent DNA binding abilities and electrochemical behaviors. The binding parameters such as binding constant, binding site size and diffusion coefficient were estimated which were comparable to literature reports. Besides, the AP probes are highly stable under PCR thermal conditions and did not inhibit PCR. Therefore, a real-time like quantification of DNA amplification was demonstrated to quantify the initial copy number of target genes. The probe AP2 has excellent ability to detect ~10(3) copies of target tpc DNA with good sensitivity. The AP probes are metal-free, easily synthesizable, non-toxic, thermally stable and feasible for miniaturized PCR chips.


Chen W.T.,National Taiwan University | Chen C.J.,National Taiwan University | Wu P.C.,National Taiwan University | Sun S.,National Taiwan University | And 9 more authors.
Optics Express | Year: 2011

We report the first three-dimensional photonic metamaterial, an array of erected U-shape plasmonic gold meta-molecules, that exhibits a profound response to the magnetic field of light incident normal to the array. The metamaterial was fabricated using a double exposure e-beam lithographic process. It was investigated by optical measurements and finite-element simulations, and showed that the magnetic field solely depends on the plasmonic resonance mode showing either enhanced in the centre of the erected U-shape meta-molecule (16 times enhancement) or enhanced around two prongs of erected U-shape meta-molecule (4 times enhancement). © 2011 Optical Society of America.


Lai Y.-A.,National Cheng Kung University | Chen C.-N.,National Cheng Kung University | Chang Y.-H.,National Cheng Kung University | Wang Y.-H.,National Cheng Kung University | Wang Y.-H.,National Applied Research Laboratory
IEEE Microwave and Wireless Components Letters | Year: 2011

A novel planar dual 180° hybrid using multicoupled line technology is presented. The proposed structure adopts the power divider and two types of multicoupled lines to improve the return loss and isolation at the balance outputs of a traditional dual Marchand balun. The proposed hybrid allows output ports to be located arbitrarily, which eliminates the complex layout while the dual 180° hybrid applied to balanced radio frequency circuits. This hybrid is designed and implemented on an FR-4 printed circuit board at 2.4 GHz. The measured return loss is lower than - 19.7 dB, and the isolation between the two-pair balanced output ports are lower than - 28.2 dB from 2.2 to 2.7 GHz. The measured insertion loss and phase imbalance between the two-pair balanced output ports are lower than 8.7 dB and 4.5°, respectively, at the operating frequency of 2.12.9 GHz. © 2010 IEEE.


Patent
National Tsing Hua University and National Applied Research Laboratory | Date: 2010-01-20

The present invention relates to methods for searching and constructing a 3D motif image database, wherein said 3D motif image database can be used to understand the connection relationship of a 3D network, e.g. a neural network comprising biological neural networks or artificial neural networks. The searching and constructing methods are applied on the 3D motif image database, a proper computer-aided graphic platform. The database not only facilitates the management of the huge amount of categorized data but also rationally excavates the hidden information cloaked within.


Patent
National Applied Research Laboratory and National Tsing Hua University | Date: 2010-08-31

The present invention provides a method for providing 3D stereo image. The method comprises: accepting a request submitted from a client system by an intermediate server system; selecting an image server based on the request and responding to the client system from the image server through a processor in the intermediate server system; requesting at least one 3D stereo image by the client system from the image server according to the response; and providing the at least one 3D stereo image to the client system by the image server system. The present invention also provides a system for providing 3D stereo image.


Patent
National Applied Research Laboratory | Date: 2011-03-25

The present invention provides an apparatus for controlling a three-dimensional optical field. The apparatus includes a light-emission device and a set of zoom elements. The light-emission device emits a light. The set of zoom elements are disposed in front of the light-emission device, and focus the light from the light-emission device.


Patent
National Applied Research Laboratory and National Tsing Hua University | Date: 2013-05-16

The present invention discloses a method for finding shortest pathways between neurons in a neural network, including: establishing a three dimensional or higher dimensional neural space database (which may be neuron image database) by a processing device in a storage space, wherein the three dimensional or higher dimensional neural space database includes a plurality of neurons distributed therein. Then, it is determined whether there is a connection between each of the plurality of neurons in the three dimensional or higher dimensional neural space database and the others of the plurality of neurons in the three dimensional or higher dimensional neural space database by the processing device, and subsequently a shortest pathway table of all of a plurality of connected neurons is calculated via an All-pairs Shortest Paths algorithm and is stored in the storage space.

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