Nation Engineering Research Center for Tissue Restoration and Reconstruction

Guangzhou, China

Nation Engineering Research Center for Tissue Restoration and Reconstruction

Guangzhou, China
SEARCH FILTERS
Time filter
Source Type

Guo X.,South China University of Technology | Guo X.,Nation Engineering Research Center for Tissue Restoration and Reconstruction | Gao H.,South China University of Technology | Liu X.,South China University of Technology | And 7 more authors.
RSC Advances | Year: 2017

A well-designed scaffold with accurately controlled structure, pore size as well as interconnection plays a key role in tissue engineering. In this study, porous Li-containing biphasic calcium phosphate scaffolds (Li-BCP) with expected structure were fabricated successfully by 3D plotting technique. The results of scanning electron microscopy (SEM) and micro-CT indicated that scaffolds from 3D plotting possessed an elaborate pore structure, porosity and interconnection. Besides, Li-BCP scaffolds also possessed excellent mechanical strength. Furthermore, in vitro cell experiments confirmed that mouse bone mesenchymal stem cells (mBMSCs) cultured on Li-BCP scaffolds exhibited good adhesion and spreading. Moreover, Li-BCP scaffolds could efficaciously promote the proliferation and osteogenic differentiation of mBMSCs, demonstrating their potential applicability as a candidate for bone repair applications. © 2017 The Royal Society of Chemistry.


Duan H.,South China University of Technology | Duan H.,Nation Engineering Research Center for Tissue Restoration and Reconstruction | Ma Y.,South China University of Technology | Ma Y.,Nation Engineering Research Center for Tissue Restoration and Reconstruction | And 6 more authors.
RSC Advances | Year: 2015

Hydroxyapatite microspheres (HAMSs) were fabricated via hydrothermal synthesis using propionamide (PA) as a pH-adjusting agent and trisodium citrate (TSC) as a regulating agent. Scanning electron microscopy (SEM) images indicated that the microspheres possessed well-defined 3D nanostructures constructed by nanoplates as building blocks. In vitro cell tests demonstrated that the HAMSs with or without heat treatment were able to promote the proliferation of mouse bone mesenchymal stem cells (mBMSCs). Gentamicin sulphate (GS), an anti-inflammatory, was successfully loaded in the HAMS particles at a distinctively high loading efficiency of approximately 87%. The resultant HAMS-GS delivery systems displayed a sustained release property, and the release of GS from the HAMS-B-GS500 system could significantly inhibit S. epidermidis growth. Moreover, the biocompatibility tests indicated that the HAMS-B-GS500 system exhibited excellent biocompatibility and had no toxic effects on the mBMSCs. These outstanding characteristics may make HAMSs a good candidate as an injectable and drug-loading biomaterial for in vivo tissue regeneration and drug control release. © The Royal Society of Chemistry.


Duan H.,Nation Engineering Research Center for Tissue Restoration and Reconstruction | Duan H.,South China University of Technology | Diao J.,Nation Engineering Research Center for Tissue Restoration and Reconstruction | Diao J.,South China University of Technology | And 4 more authors.
Materials Letters | Year: 2016

Hollow mesoporous bioactive glass microspheres (HMBGMs) were fabricated via a hydrothermal-assisted self-transformation method employing cetyltrimethyl ammonium bromide (CTAB) as a mesoporous template. The morphology, structure, particle size and specific surface area of HMBGMs were characterized by various methods. The results demonstrated that the solid BG spheres prepared in a Stöber solution could spontaneously transform to hollow structure by incubating in hydrothermal condition. Meanwhile, the shell thickness of HMBGMs could be controlled by the hydrothermal time. In vitro drug release studies demonstrated that the HMBGMs exhibited a sustained release property. The obtained HMBGMs may have potential applications in drug delivery and bone tissue regeneration. © 2015 Elsevier B.V. All rights reserved.

Loading Nation Engineering Research Center for Tissue Restoration and Reconstruction collaborators
Loading Nation Engineering Research Center for Tissue Restoration and Reconstruction collaborators