Narsinhbhai Patel Dental College and Hospital

Visnagar, India

Narsinhbhai Patel Dental College and Hospital

Visnagar, India
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Singh H.V.,Hindu Rao Hospital | Pandey A.,Narsinhbhai Patel Dental College and Hospital | Raizada A.,Medicity | Singh S.K.,G R Medical College | Singh N.,G R Medical College
Clinica Chimica Acta | Year: 2013

Background: The blood-brain barrier is compromised in stroke patients. The release of neuro-biochemical protein markers, such as Neuron Specific Enolase (NSE) into the circulation may allow the pathophysiology and prognosis of patients with cerebrovascular diseases to be evaluated further. Method: Present study aimed to investigate the predictive value of NSE and Interleukin-10 (IL-10) with respect to early neurobehavioral outcome which evaluated by National Institute of Health Stroke Scale (NIHSS). We investigated 100 patients of ischemic stroke and blood samples were taken within first 72. h of stroke onset. NSE and IL-10 were analyzed by commercially available ELISA kits. The neurological status was evaluated by a standardized NIHSS at the time of admission. Results: NSE was significantly increased (17.95 ± 4.54 vs 7.48 ± 1.51 {ng/ml} p ≤ 0.05) and IL-10 significantly decreased (11.79 ± 2.77 vs 15.72 ± 2.69 {pg/ml} p ≤ 0.05) in patients when compared with controls. NSE also significantly (r = 0.8, p ≤ 0.001) correlated with degree of neurological deficit but IL-10 level in serum did not show any significant correlation with NIHSS score at the time of admission. Conclusions: Serum concentrations of NSE and IL-10 have a high predictive value for early neurobehavioral outcome after acute stroke. © 2013 Elsevier B.V.


Singh H.V.,Hindu Rao Hospital | Raizada A.,Medicity | Singh S.K.,G R Medical College | Pandey A.,Narsinhbhai Patel Dental College and Hospital | And 3 more authors.
Allergologia et Immunopathologia | Year: 2015

Background: Autoimmune diseases such as rheumatoid arthritis (RA) are the consequence of a persistent imbalance between pro- and anti-inflammatory immune mechanisms, leading to chronic inflammation. The objective of this study was to determine whether the high sensitive C-reactive protein (hs-CRP) and cytokines are elevated in RA patients and to investigate the relationship between these markers and disease activity in RA, measured by disease activity score 28 (DAS28). Methods: We studied 110 RA patients according to American College of Rheumatology revised criteria for RA, and 55 controls matched by age and sex. Serum levels of hs-CRP and cytokines interleukin (IL)-6, IL-10 and tumour necrosis factor-α (TNF-α) were estimated and correlated with the DAS28. Serum hs-CRP was assayed immunoturbidimetrically and cytokines were analysed by commercially available ELISA kit. Results: We found that RA patients had significantly higher levels of serum hs-CRP (p<. 0.001), IL-6 (p<. 0.001), TNF-α (p<. 0.001), and IL-10 (p<. 0.01) as compared to healthy controls. hs-CRP, IL-6 and TNF-α correlated positively (p<. 0.001) and IL-10 correlated negatively (p<. 0.01) with DAS28. Conclusions: These results demonstrate that RA patients have high levels of inflammatory markers, and these levels are correlated with the DAS28. These findings suggest a possible role of these markers in the pathogenesis of RA. Moreover, these biomarkers can be used as markers of disease activity in the diagnosis and treatment of RA. © 2013 SEICAP.


Singh K.,Narsinhbhai Patel Dental College and Hospital | Kallali B.,Narsinhbhai Patel Dental College and Hospital | Kumar A.,Narsinhbhai Patel Dental College and Hospital | Thaker V.,Narsinhbhai Patel Dental College and Hospital
Asian Pacific Journal of Tropical Biomedicine | Year: 2011

The field of probiotics is an evolving field. Probiotics were first introduced to the world as a functional ingredient in dairy products, breakfast cereals and snacks. Unknown to many, probiotics offer health benefits that go beyond the scope of supporting digestive health. Research continues to emerge, supporting the use of different probiotic strains in a variety of conditions. The research now suggests that these "healthy" bacteria have beneficial effects on gastrointestinal dysfunctions, including diarrhea, as well as the immune system and conditions such as allergy, in children, adults, and in the oral cavity. Research on the horizon will develop a better understanding of the concepts of how colonizing microbes and probiotics can influence human health.


Kemparaj U.,Narsinhbhai Patel Dental College and Hospital | Chavan S.,Narsinhbhai Patel Dental College and Hospital
Indian Journal of Medical Sciences | Year: 2013

Qualitative research refers to, a range of methodological approaches which aim to generate an in-depth and interpreted understanding of the social world, by learning about people's social and material circumstances, their experiences, perspectives, and histories. Requires researchers to become intensely involved, often remaining in field for lengthy periods of time. The greatest value of qualitative research is its ability to address questions of relevance to public health knowledge and practice which are difficult to answer satisfactorily using quantitative methods.


Vachhani K.A.,Narsinhbhai Patel Dental College and Hospital | Asnani M.M.,Narsinhbhai Patel Dental College and Hospital
Nigerian Journal of Clinical Practice | Year: 2015

Aims: The aim was to evaluate the incidence of root fracture of endodontically treated teeth reinforced with glass-fiber posts and metal posts luted with different luting cements. Materials and Methods: Forty maxillary central incisors were sectioned at 1 mm of the cementoenamel junction and endodontically treated. The teeth were divided into four groups (n = 10) and restored with prefabricated metal posts and glass-fiber posts luted with resin-based luting cement and glass ionomer cement. Core built up was done using composite resin. The fracture strength was evaluated using an Instron universal testing machine (Model 4206, Instron Corp., Canton, MA). The results were recorded. Statistical Analysis Used: The Kruskal-Wallis test analysis test was used to analyze the data. Results: Prefabricated metal post was statistically superior to the glass-fiber posts. Posts luted with resin-based luting cement were superior in fracture strength than glass ionomer cement. Conclusions: Teeth restored with prefabricated metal posts present higher fracture strength than those reinforced with glass-fiber posts. Posts luted with resin-based luting cement showed higher fracture strength than glass ionomer cement.


Satpathy A.,Narsinhbhai Patel Dental College and Hospital | Gujjari A.K.,JSS Dental college and hospital
Journal of Clinical and Diagnostic Research | Year: 2015

Microstomia is the term used to describe a condition of reduction in the size of oral aperture which can be either acquired or congenital and affects the quality of life. Dentists occasionally come across patients with constricted oral openings. Limited oral opening makes access to the oral cavity for any dental procedure difficult. It’s the duty of a dentist to provide every possible care to the patient with microstomia. This paper describes the treatment of a microstomia patient requiring complete dentures using sectional dentures. The cause of microstomia in the indexed patient was developmental in nature as all other causes of related conditions were ruled out. Finally upper and lower complete denture with sectional components were given to the patient after modification in conventional steps of its construction. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.


Patel R.V.,Narsinhbhai Patel Dental College and Hospital | Thaker V.T.,Narsinhbhai Patel Dental College and Hospital | Patel V.K.,Narsinhbhai Patel Dental College and Hospital
Asian Pacific Journal of Tropical Biomedicine | Year: 2011

Objective: To evaluate the in vitro effects of ginger and honey on micro-organisms on carious teeth by employing antibiotic sensitivity test. Methods: Two hundred and fifty (250) extracted, carious teeth were aseptically collected into sterile peptone water. Bacterial species were isolated from the peptone water broth, characterized and identified according to standard methods described in the Manual of Clinical Microbiology. Aqueous ginger extract and honey were employed for sensitivity test. Suspensions of the bacterial isolates were made in sterile normal saline and adjusted to the 0.5 McFarland's standard. Each Mueller Hinton (MH) agar plate was uniformly seeded by means of sterile swab dipped in the suspension and streaked on the agar plate surface, and the plates left on the bench for excess fluid to be absorbed. Approximately 100 μ L of the extracts were dropped into each well which filled them respectively to fullness. The setup was allowed to stabilize for 3 h before being incubated at 37 °C for 24 h. The mean zones of inhibition were thereafter measured in mm, for all the individual isolates. Results: Streptococcus mutans (88.0%) and Lactobacillus acidophilus (L. acidophilus) (39.0%) were most prevalent as compared with other isolates. The diameter of the zone of inhibition ranged from (18.0 ± 0.5) mm to (27.0 ± 1.0) mm for ginger and (20.0 ± 0.5) mm to (27.0 ± 0.7) mm for honey, as compared with (18.0 ± 0.7) mm to (23.0 ± 0.5) mm for gentamycin, at the various concentrations used. Results indicate a considerable antibacterial activity of ginger and honey. The combined extracts were most effective against Staphylococcus aureus (30.0.0 ± 1.5) mm but least effective against L. acidophilus (21.0 ± 0.7) mm. Conclusions: For the prevention of the emergence of resistant microorganisms, use of combination of herbal preparations is more useful.Considering in vitro data obtained in this study, there is a significant synergistic effect of antimicrobial activity from the combination of ginger and honey, against isolates from carious teeth.


PubMed | Narsinhbhai Patel Dental College and Hospital
Type: Journal Article | Journal: Journal of maxillofacial and oral surgery | Year: 2016

Orthokeratinized odontogenic cyst (OOC) is a rare developmental jaw cyst, considered as distinct entity from odontogenic keratocysts as it exhibits a less aggressive behaviour and a very low rate of recurrence. Most commonly occurs in mandibular molar and ramus region, rarely seen in maxilla and mandibular premolar area. But till now never reported in condyle, this article describes a case of OOC involving the mandibular condylar head in a 41-year-old male. The initial clinical diagnosis was given as TMD based on the clinical features, but radiographic evaluation revealed osteolytic lesion in right side condylar head. Condylotomy was performed and the specimen was sent for histopathological examination. A definite diagnosis of OOC was made by histopathological examination of the biopsy specimen. We report a rare entity in this article with its management.


PubMed | Krishna University, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital Nagpur, Prince Sattam Bin Abdulaziz University, King Khalid University and 2 more.
Type: Journal Article | Journal: The journal of contemporary dental practice | Year: 2016

The present study was aimed to assess the fasting and postprandial gingival crevicular blood (GCB) glucose and finger stick blood glucose measurements using a glucometer.A total of 30 subjects with periodontitis and positive bleeding on probing were considered. Subjects were instructed to report to the department after overnight fasting. Gingival crevicular blood samples were collected from anterior region showing bleeding on probing followed by finger stick blood sample collection. Then, the patients were instructed to take 75 gm of glucose and after 2 hours blood samples from two sites were collected similarly. Results were analyzed using unpaired t test and Pearsons correlation.Mean glucose levels form GCB and finger stick blood did not differ either during fasting or postprandial (p > 0.05). Significant correlation was found between GCB glucose levels and capillary finger stick blood (CFB) glucose levels during fasting (r = 0.946, p < 0.001) and postprandial (r=0.930, p < 0.001) blood estimation.Periodontal probing can be considered as an alternate noninvasive method of blood glucose estimation for screening of diabetes mellitus (DM). The technique described is safe, easy to perform, and helps to increase the frequency of diabetes screening in dental office.The GCB from probing can be a good source of blood for estimating blood glucose levels and screening for diabetes using portable glucose monitors. Also, it will be a simple and relatively inexpensive in office screening procedure for any patient suspected to have diabetes.


Shah M.P.,Narsinhbhai Patel Dental College and Hospital | Gujjari S.K.,Jss Dental College And Hospital | Chandrasekhar V.S.,Jss Dental College And Hospital
Journal of Clinical and Diagnostic Research | Year: 2013

Introduction: The purpose of the present study was to evaluate the effect of a probiotic (Inersan®) alone, a combination of the probiotic with doxycycline and doxycycline alone on aggressive periodontitis patients. Methods: Thirty patients who satisfied the inclusion and exclusion criteria, were assigned to one of the above mentioned three groups by using block randomization. The clinical and the microbiological parameters were recorded on day 0, at 2 weeks and at 2 months. On day 0, before recording the clinical parameters, 0.5 ml of un stimulated saliva was collected for the evaluation of the microbiological parameters. The clinical parameters which were recorded were the plaque index, the gingival index, the probing pocket depth and the clinical attachment level. The microbiological parameters which were recorded were Lactobacilli and Aggregatibacter actinomyce-temcomitans. After this, Scaling and Root Planing (SRP) was performed on day 0. Two weeks after the SRP, the patients were recalled for the saliva sample collection and for the evaluation of the clinical parameters. On the same day, medications were given to the patients to be taken for fourteen days according to the group which they belonged to (Group A - pro-biotic alone, Group B - a combination of the probiotic with doxycycline, Group C doxycycline alone). The patients were then recalled at two months for the saliva sample collection and for the evaluation of the clinical parameters. Results: The administration of the probiotic alone, a combination of the probiotic with doxycycline and doxycycline alone, resulted in a decrease in the plaque index, the gingival index, the probing pocket depth and the clinical attachment level at 2 months, which was statistically significant (p < 0.05). The A. ac-tinomycetemcomitans count tended to decrease in all the three groups at 2 months, which was statistically non-significant (p > 0.05). The Lactobacilli count tended to increase signifcantly in the probiotic alone group (p < 0.05). Conclusion: Probiotics have a future in the treatment of aggressive periodontitis, as antibiotics are prescribed most of the time. These antibiotics can lead to the emergence of drug resistant micro-organisms and they can also disturb the beneficial microfora of the body. Thus, as an alternative to antibiotics, probiotics can be used, as they repopulate the beneficial microfora and reduce the pathogenic bacteria.

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