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Mumbai, India

Narsee Monjee Institute of Management Studies is a private university located in Mumbai, Maharashtra, India. This institute was established in 1981 by the parent body Shri Vile Parle Kelavani Mandal. It has been awarded "Five Star" rating and "A" grade by the NAAC and UGC respectively. NMIMS has also been awarded the ISO 9001:2000 Certification by ICL in 2004 and a "A***" rating by CRISIL. The institute was granted "Deemed University" status by the UGC in 2003 and can hence grant full academic degrees on its students. It has campuses in Mumbai, Shirpur, Bengaluru and Hyderabad. It offers courses/programs across diverse fields such as Management, Technology, Science, Architecture, Pharmacy, Commerce and Economics. Wikipedia.

Veeranjaneyulu A.,Narsee Monjee Institute of Management and Higher Studies
Archives of Medical Research | Year: 2014

Background and Aims: Diabetes is a risk factor for exacerbated outcome after acute myocardial infarction (AMI) and doubles the risk of mortality after MI. Increased levels of MMP-2 and MMP-9 in diabetes cause vascular remodelling, which leads to cardiovascular complications of diabetes. We hypothesized that inhibition of MMP-2 and MMP-9 can reduce worsening of myocardial ischemia in diabetic patients. Further, we hypothesized that minocycline induced MMP-2 and MMP-9 inhibition will be potentiated by aspirin and the combination of both drugs will prevent worsening of MI in diabetic patients. In the present study, efficacy of combination of minocycline and aspirin to attenuate exacerbation of myocardial ischemia/reperfusion (I/R) injury in diabetic rats was evaluated. Methods: Diabetes was induced in male Wistar rats by streptozotocin (55 mg/kg i.p.). Three weeks after diabetes induction, rats were treated with minocycline (50 mg/kg, p.o.), aspirin (50 mg/kg, p.o.), or minocycline (50 mg/kg, p.o.) plus aspirin (50 mg/kg, p.o.) for a period of 3 weeks. At the end of week 6, I/R injury was induced by ligating the left anterior descending coronary artery for 30 min followed by 2 h reperfusion. Results: Percentage infarct volume, arrhythmias, mortality, collagen level and MMP-2 and MMP-9 level were significantly increased in vehicle-treated diabetic group when compared with normoglycemic rats. Treatment with a combination of minocycline and aspirin decreased percentage infarct volume, arrhythmias, mortality and collagen level when compared with vehicle-treated diabetic controls and showed reduced levels of MMP-2 and MMP-9. Conclusions: Results of the present study suggest that the combination of minocycline and aspirin prevent worsening of AMI in diabetic rats. © 2014 IMSS.

Pandharinath R.R.,Narsee Monjee Institute of Management and Higher Studies
Journal of Ayurveda and Integrative Medicine | Year: 2011

Dr. Ashok D.B. Vaidya, the stalwart in the fields of Experimental Pharmacology, Clinical Pharmacology, and Reverse Pharmacology turns 75 on Nov, 27, 2011. A former Clinical Research Head of CIBA Geigy Research Centre, his name has been synonymous with the concept of the Golden Triangle for resurgence of Ayurveda and its reinterpretation in modern scientific terms. At a time when most fields are populated by intellectual dwarfs and unethical operators, he stands like a giant-a scientist, a philosopher, and an ardent fighter for ethical values. In this free-wheeling interview with Ravindra R.Pandharinath, he discusses the milestones in his life, his inspirations, and dreams for the confluence of modern science, modern medicine, and Ayurveda as the new health care model for the 21st century.

Majumdar S.H.,Narsee Monjee Institute of Management and Higher Studies
International Journal of Pharma and Bio Sciences | Year: 2012

Semecarpus anacardium (SA) popularly known as marking nut has been used in folklore for the treatment of a wide range of diseases. Extracts (hydro-alcoholic and oil) of SA were evaluated for their anticancer activity against Ehrlich ascites carcinoma (EAC) in nude mice. Extracts and standard drug (cyclophosphamide) at a dose of 20 mg/kg body weight were administered orally and continued for 10 consecutive days. The anticancer activity of SA was examined by determining the tumor area, tumor volume and tumor histology in experimental animal models. Both these extracts showed remarkable results in controlling the tumor in EAC bearing nude mice compared to the standard drug cyclophosphamide. Thus, the present study revealed that SA showed anticancer activity in the tested animal models.

Das S.,Narsee Monjee Institute of Management and Higher Studies | Suresh P.K.,Pandit Ravishankar Shukla University
Nanomedicine: Nanotechnology, Biology, and Medicine | Year: 2011

Present limitations in the management of ophthalmic fungal infections include the inability to provide long-term extraocular drug delivery without compromising intraocular structures and/or systemic drug exposure. In the present study, the potential of Eudragit RS 100 nanoparticles (NPs) as a new vehicle for the improvement of the delivery of drugs to the ocular mucosa was investigated. Amphotericin B (AmB) was chosen as a model compound because of its potential usefulness for the treatment of fungal diseases. A solvent displacement technique was used to produce AmB-loaded Eudragit NPs. These NPs had a mean size range of 150-290 nm and a zeta potential of +19-28 mV. Even after 6 months of stability study, results were unchanged, indicating the good potential for ocular application. In vitro release studies revealed that a maximum amount of drug was released within 24 hours (60%). The results obtained from microbial assay showed that the antifungal activity of drug-loaded NPs was equal to or slightly lower than that of free-AmB solution. In vivo experiments showed that, following topical instillation of nanosuspension to a rabbit's eye there was no irritation. From these results we can conclude that Eudragit RS 100 nanosuspension may represent an efficacious vehicle to deliver the drug into the eye. From the Clinical Editor: Amphotericin B encapsulated into Eudragit, a mildly cationic nanoparticle, was shown to have 6 month stability, release 60% of its drug payload in dissolution within 24 hours, and elicited no irritation when instilled into rabbit eyes. The concept is being considered for local ophthalmologic therapy of fungal disease. © 2011 Elsevier Inc.

Tiwari R.N.,Narsee Monjee Institute of Management and Higher Studies | Bonde C.G.,Narsee Monjee Institute of Management and Higher Studies
Journal of Pharmaceutical and Biomedical Analysis | Year: 2011

The objective of the present investigation was to separate, identify and characterize the major degradation products (DPs) of nelfinavir mesylate generated under hydrolytic, oxidative, photolytic and thermal stress conditions as advised in International Conference on Harmonization (ICH) guideline Q1A(R2). The drug was found to degrade under acidic, basic, oxidative and photolytic stress, while it was stable in neutral and thermal stress conditions. A total of three degradation products were formed, which were separated on a C-18 column employing a gradient HPLC method. A complete mass fragmentation pathway of the drug was first established with the help of multi-stage (MSn) and MS/TOF accurate mass studies. Then stressed samples were subjected to LC-MS/TOF studies, which provided their fragmentation pattern and accurate masses. The mass spectral data were employed to characterize the DPs and assign structures to them. The total information was also used to establish the degradation pathway of the drug. The degradation products were identified as 3-hydroxy-N-((2R,3R)-3-hydroxy-1-(phenylthio)butan-2-yl)-2-methylbenzamide and (3S,4aS,8aS)-N-tert-butyl-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(phenylsulfinyl)butyl)decahydroisoquinoline-3-carboxamide. © 2011 Elsevier B.V.

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