Narsee Monjee Institute of Management and Higher Studies
Mumbai, India

Narsee Monjee Institute of Management Studies is a private university located in Mumbai, Maharashtra, India. This institute was established in 1981 by the parent body Shri Vile Parle Kelavani Mandal. It has been awarded "Five Star" rating and "A" grade by the NAAC and UGC respectively. NMIMS has also been awarded the ISO 9001:2000 Certification by ICL in 2004 and a "A***" rating by CRISIL. The institute was granted "Deemed University" status by the UGC in 2003 and can hence grant full academic degrees on its students. It has campuses in Mumbai, Shirpur, Bengaluru and Hyderabad. It offers courses/programs across diverse fields such as Management, Technology, Science, Architecture, Pharmacy, Commerce and Economics. Wikipedia.

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Masurkar P.P.,Narsee Monjee Institute of Management and Higher Studies
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

India is one of the top producers of generics globally and is currently being recognized as the “pharmacy of the world” for the generic drug products. Thus, there is a need that it has best health-care systems in place to regulate and provide better quality drugs by monitoring the possible risk associated with the use of drugs. Being the generic hub, physicians, pharmacists, etc., should be erudite to provide an alternative cost-effective generic medicine, which is one of the education-related aspects of pharmacovigilance. We need a more systematic approach to surveillance of drug-related problems, which is at the heart of pharmacovigilance. The health-care system requires new processes to understand the risk-benefit ratio of drugs. The challenges in implementation of better pharmacovigilance in country due to nonavailability of trained staff in pharmacovigilance, lack of training of health-care professionals on drug safety, and adverse drug reaction reporting which comprises adverse interactions of medicines with chemicals, other medicines, and food are often neglected leading to under-reporting by health-care professionals as well as patients, lack of expertise, etc., should be overcome by Indian regulatory body via practical oriented knowledge-based system. The web market monitoring, global electronic database, education, association of stakeholders and regulation of herbal medicines standards and allied medicinal systems are vital restructurings needed to be introduced for a better pharmacovigilance system in India. © 2017 The Authors.

Veeranjaneyulu A.,Narsee Monjee Institute of Management and Higher Studies
Archives of Medical Research | Year: 2014

Background and Aims: Diabetes is a risk factor for exacerbated outcome after acute myocardial infarction (AMI) and doubles the risk of mortality after MI. Increased levels of MMP-2 and MMP-9 in diabetes cause vascular remodelling, which leads to cardiovascular complications of diabetes. We hypothesized that inhibition of MMP-2 and MMP-9 can reduce worsening of myocardial ischemia in diabetic patients. Further, we hypothesized that minocycline induced MMP-2 and MMP-9 inhibition will be potentiated by aspirin and the combination of both drugs will prevent worsening of MI in diabetic patients. In the present study, efficacy of combination of minocycline and aspirin to attenuate exacerbation of myocardial ischemia/reperfusion (I/R) injury in diabetic rats was evaluated. Methods: Diabetes was induced in male Wistar rats by streptozotocin (55 mg/kg i.p.). Three weeks after diabetes induction, rats were treated with minocycline (50 mg/kg, p.o.), aspirin (50 mg/kg, p.o.), or minocycline (50 mg/kg, p.o.) plus aspirin (50 mg/kg, p.o.) for a period of 3 weeks. At the end of week 6, I/R injury was induced by ligating the left anterior descending coronary artery for 30 min followed by 2 h reperfusion. Results: Percentage infarct volume, arrhythmias, mortality, collagen level and MMP-2 and MMP-9 level were significantly increased in vehicle-treated diabetic group when compared with normoglycemic rats. Treatment with a combination of minocycline and aspirin decreased percentage infarct volume, arrhythmias, mortality and collagen level when compared with vehicle-treated diabetic controls and showed reduced levels of MMP-2 and MMP-9. Conclusions: Results of the present study suggest that the combination of minocycline and aspirin prevent worsening of AMI in diabetic rats. © 2014 IMSS.

Yadav S.,Narsee Monjee Institute of Management and Higher Studies | Ramachandran M.,Narsee Monjee Institute of Management and Higher Studies
Materials Today: Proceedings | Year: 2017

The main objective of this work is to analyze the causes of failure in wind turbine and eliminate the highest contributing root cause problem, thereby reducing the failure rate of wind turbine. As we know, Wind Energy is a renewable source of energy, so there will be a constant generation of wind energy throughout the year. In the next 50 to 100 years the fossil fuels may get exhausted. So, we may not get coal continuously for thermal power generation. Hence it is essential to cease the dependence on conventional energy sources and switch over to non-conventional energy sources like wind energy. Wind possesses energy by virtue of its motion. Any device that is capable of slowing down the mass of moving air, like a sail or propeller, can extract a part of the energy and convert it into useful work. The factors which determine the output, getting from a wind energy converter includes; wind speed, cross section of the windswept by the rotor, overall conversion efficiency of the rotor, transmission system and generator or pump. In this paper, complete analysis is performed on the existing wind turbine blade for better performance. A Reference blade of 10m length approximately with a rated output of 100KW was taken for study. © 2017 Elsevier Ltd.

More A.,Narsee Monjee Institute of Management and Higher Studies
International Conference on Electronic Devices, Systems, and Applications | Year: 2017

In energy-constrain wireless sensor networks, maintaining k - coverage degree requested by an application while maximizing the network lifetime is a major challenge. Existing literature on k - coverage does not consider residual energy levels and actual battery discharge rate of ACTIVE nodes. OBSP (Optimized Backoff Sleep Protocol) considers the residual energy level information and battery discharge rate but ignores the k-coverage degree. This paper proposes k-CGP (k-Coverage Guarantee Protocol) based on battery discharge curve using polynomial regression for different coverage degrees (k). k-CGP determines the optimal wakeup rate of sleeping nodes by computing Optimal Sleep Time derived from battery discharge curve using polynomial regression and Received Signal Strength Indicator for distance estimation. The coverage redundancy is computed by using equi-distance test. Due to this, a sufficient number of ACTIVE nodes could be maintained while achieving lesser energy consumption in the network. Simulation results show that k-CGP achieves higher energy savings and sensing area coverage as compared to PEAS. © 2016 IEEE.

Kharkar P.S.,Narsee Monjee Institute of Management and Higher Studies
Expert Opinion on Therapeutic Patents | Year: 2017

Introduction: Cancer stem cells (CSCs) mediate tumor initiation and maintenance. These cells are chemoresistant and possess characteristics such as self-renewal, pluripotency, plasticity and differentiation. They have aberrant or altered signaling pathways depending on tumor microenvironment, tumor type, etc. CSCs are responsible for highly aggressive and invasive form of the disease following chemo- and/or radiotherapy. Eliminating CSCs is likely to improve the survival rate in patients. Several anti-CSC strategies and associated targets have been proposed and validated till date. Areas covered: The main emphasis is on the patent applications/patents filed/granted in the last few years (2012–2015). The anti-CSC agents are discussed under two broad headings–small- and macromolecules. Different subclasses are further elaborated, e.g., kinase inhibitors, polypeptides, etc. Expert opinion: Clinical development of small- and macromolecular anti-CSC therapeutics is underway. Few of these agents act on validated targets such as kinases. Potential problems with these agents can be envisaged based on our understanding of target biology. Other issues governing the choice of small- versus macromolecules include druggability of the target, ease of its modulation and the presence of compensatory mechanisms. Drug repurposing can be attempted to discover newer anti-CSC drugs quickly. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Apraj V.D.,Narsee Monjee Institute of Management and Higher Studies | Pandita N.S.,Narsee Monjee Institute of Management and Higher Studies
Pharmacognosy Research | Year: 2016

Background: The peel of Citrus reticulata Blanco is traditionally used as tonic, stomachic, astringent, and carminative. It is also useful in skin care. Objective: To study the anti-aging potential of alcoholic extracts of C. reticulata Blanco peel using in vitro antioxidant and anti-enzyme assays. Materials and Methods: Plant extracts were obtained by Soxhlation (CR HAE- Hot Alcoholic Extract of Citrus reticulata) and maceration method (CR CAE- Cold Alcoholic Extract of Citrus reticulata). Qualitative and quantitative phytochemical analysis was performed. Further, in vitro antioxidant, anti-enzyme, and gas chromatography-mass spectrometry (GC-MS) analyses were performed. Results: Total phenolic and flavonoid contents of CR HAE were found to be higher than CR CAE. EC50value of CR HAE and CR CAE for 1,1-Diphenyl-2-picrylhydrazyl, Superoxide anion, and 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) assays were 250.33 ± 40.16 μg/ml and 254.73 ± 15.78 μg/ml, 221.27 ± 11.25 μg/ml and 354.20 ± 23.79 μg/ml, and 59.16 ± 2.17 μg/ml and 59.12 ± 6.21 μg/ml, respectively. Oxygen radical absorbance capacity values for CR HAE and CR CAE were found to be 1243 and 1063 μmoles 6-hydroxy-2,5,7,8-tetra methylchromane-2-carboxylic acid equivalent/g of substance, respectively. Anti-collagenase and anti-elastase activities were evaluated for both CR HAE and CR CAE. EC50values of CR HAE and CR CAE for anti-collagenase and anti-elastase were 329.33 ± 6.38 μg/ml, 466.93 ± 8.04 μg/ml and 3.22 ± 0.24 mg/ml, 5.09 ± 0.30 mg/ml, respectively. CR HAE exhibited stronger anti-collagenase and anti-elastase activity than CR CAE. GC-MS analysis of CR HAE was carried out because CR HAE exhibited higher antioxidant and anti-enzyme potential than CR CAE. Conclusion: C. reticulata peel can be utilized in anti-wrinkle skin care formulations. © 2016 Pharmacognosy Research Published by Wolters Kluwer - Medknow.

Sahu N.U.,Narsee Monjee Institute of Management and Higher Studies | Kharkar P.S.,Narsee Monjee Institute of Management and Higher Studies
Current Topics in Medicinal Chemistry | Year: 2016

Computational drug repositioning is popular in academia and pharmaceutical industry globally. The repositioning hypotheses, generated using a variety of computational methods, can be quickly tested experimentally. Several success stories have emerged in the past decade or so. Newer concepts and methods such as drug profile matching are being tried to address the limitations of current computational repositioning methods. The trend is shifting from earlier small-scale to large-scale or global-scale repositioning applications. Other related approaches such as prediction of molecular targets for novel molecules, prediction of side-effect profiles of new molecular entities (NMEs), etc., are applied routinely. The current article focuses on state-of-the-art of computational drug repositioning field with the help of relevant examples and case studies. This ‘lateral’ approach has significant potential to bring down the time and cost of the awfully expensive drug discovery research and clinical development. The persistence and perseverance in the successful application of these methods is likely to be paid off in near future. © 2016 Bentham Science Publishers.

Wairkar S.,Narsee Monjee Institute of Management and Higher Studies | Gaud R.,Narsee Monjee Institute of Management and Higher Studies
AAPS PharmSciTech | Year: 2016

The aim of the present work was to prepare a co-amorphous mixture (COAM) of Nateglinide and Metformin hydrochloride to enhance the dissolution rate of poorly soluble Nateglinide. Nateglinide (120 mg) and Metformin hydrochloride (500 mg) COAM, as a dose ratio, were prepared by ball-milling technique. COAMs were characterized for saturation solubility, amorphism and physicochemical interactions (X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR)), SEM, in vitro dissolution, and stability studies. Solubility studies revealed a sevenfold rise in solubility of Nateglinide from 0.061 to 0.423 mg/ml in dose ratio of COAM. Solid-state characterization of COAM suggested amorphization of Nateglinide after 6 h of ball milling. XRPD and DSC studies confirmed amorphism in Nateglinide, whereas FTIR elucidated hydrogen interactions (proton exchange between Nateglinide and Metformin hydrochloride). Interestingly, due to low energy of fusion, Nateglinide was completely amorphized and stabilized by Metformin hydrochloride. Consequently, in vitro drug release showed significant increase in dissolution of Nateglinide in COAM, irrespective of dissolution medium. However, little change was observed in the solubility and dissolution profile of Metformin hydrochloride, revealing small change in its crystallinity. Stability data indicated no traces of devitrification in XRPD of stability sample of COAM, and % drug release remained unaffected at accelerated storage conditions. Amorphism of Nateglinide, proton exchange with Metformin hydrochloride, and stabilization of its amorphous form have been noted in ball-milled COAM of Nateglinide-Metformin hydrochloride, revealing enhanced dissolution of Nateglinide. Thus, COAM of Nateglinide-Metformin hydrochloride system is a promising approach for combination therapy in diabetic patients. © 2015, American Association of Pharmaceutical Scientists.

Das S.,Narsee Monjee Institute of Management and Higher Studies | Suresh P.K.,Pandit Ravishankar Shukla University
Nanomedicine: Nanotechnology, Biology, and Medicine | Year: 2011

Present limitations in the management of ophthalmic fungal infections include the inability to provide long-term extraocular drug delivery without compromising intraocular structures and/or systemic drug exposure. In the present study, the potential of Eudragit RS 100 nanoparticles (NPs) as a new vehicle for the improvement of the delivery of drugs to the ocular mucosa was investigated. Amphotericin B (AmB) was chosen as a model compound because of its potential usefulness for the treatment of fungal diseases. A solvent displacement technique was used to produce AmB-loaded Eudragit NPs. These NPs had a mean size range of 150-290 nm and a zeta potential of +19-28 mV. Even after 6 months of stability study, results were unchanged, indicating the good potential for ocular application. In vitro release studies revealed that a maximum amount of drug was released within 24 hours (60%). The results obtained from microbial assay showed that the antifungal activity of drug-loaded NPs was equal to or slightly lower than that of free-AmB solution. In vivo experiments showed that, following topical instillation of nanosuspension to a rabbit's eye there was no irritation. From these results we can conclude that Eudragit RS 100 nanosuspension may represent an efficacious vehicle to deliver the drug into the eye. From the Clinical Editor: Amphotericin B encapsulated into Eudragit, a mildly cationic nanoparticle, was shown to have 6 month stability, release 60% of its drug payload in dissolution within 24 hours, and elicited no irritation when instilled into rabbit eyes. The concept is being considered for local ophthalmologic therapy of fungal disease. © 2011 Elsevier Inc.

Garud M.S.,Narsee Monjee Institute of Management and Higher Studies | Kulkarni Y.A.,Narsee Monjee Institute of Management and Higher Studies
Current Diabetes Reviews | Year: 2014

Nephropathy is one of the major complications of diabetes which further directs to end stage renal disease. Extensive work has been done to find out the mechanisms involved in pathogenesis of the DN. Now, many researchers have been convinced that almost all of the molecular mediators and intracellular signaling pathways involved in progression of diabetic nephropathy have involvement in transforming growth factor beta (TGF- β) at some stage. In DN, hyperglycemia causes increase in the expression of TGF- β genes, TGF- β proteins and their receptors. Increased glucose level mediates these effects through activation of polyol pathway, protein kinase C pathway, hexosamine pathway, increases advanced glycation end products (AGE) and increases oxidative stress. Hyperglycemia also activates the TGF- β via activation of glucose transporters (GLUT), angiotensine II and platelet derived growth factor (PDGF). Activated TGF-β further leads to glomerular basement membrane (GBM) thickening and glomerulosclerosis through activation of connective tissue growth factor (CDGF) and vascular endothelial growth factor (VEGF). We have discussed the progression of hyperglycemia to DN via TGF- β, whose schematic presentation may serve as an effective way to understand the mechanisms and to find out an effective way for the management of diabetic nephropathy. © 2014 Bentham Science Publishers.

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