Narodni Front Clinic of Gynecology and Obstetrics

Belgrade, Serbia

Narodni Front Clinic of Gynecology and Obstetrics

Belgrade, Serbia

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Ardalic D.,Narodni Front Clinic of Gynecology and Obstetrics | Stefanovic A.,University of Belgrade | Kotur-Stevuljevic J.,University of Belgrade | Vujovic A.,University of Belgrade | And 8 more authors.
Advances in Clinical and Experimental Medicine | Year: 2014

Background: As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants can also disrupt the prooxidant/antioxidant relationship and contribute to oxidative stress. Increased oxidative stress during pregnancy may be involved in several complications of pregnancy, such as preterm labor, fetal growth restriction, preeclampsia and miscarriage. Objectives. The aim of this study was to investigate the influence of maternal smoking habits before pregnancy on the parameters of, oxidative stress and the antioxidative defense system, lipid profile parameters and paraoxonase-1 (PON1) activity during the third trimester of uncomplicated pregnancies. Material and Methods: Healthy pregnant women (n = 86) were divided into non-smoking and smoking groups, and into groups taking vitamin supplements and not taking them. Oxidative damage was measured through the levels of thiobarbituric acid-reacting substances (TBARS) and plasma antioxidant status was evaluated by measuring total antioxidant capacity (TAC). Results: TBARS concetration was significantly higher (p < 0.05) and PON1 activity was significantly lower (p < 0.05) in the smokers' group. No significant differences were found in the investigated parameters in relation to vitamin supplement intake. Conclusions: Habitual smoking before pregnancy is associated with increased oxidative stress. Vitamin supplementation has no effect on the oxidative stress status of healthy pregnant women. © Copyright by Wroclaw Medical University.


PubMed | Narodni Front Clinic of Gynecology and Obstetrics and University of Belgrade
Type: Journal Article | Journal: Advances in clinical and experimental medicine : official organ Wroclaw Medical University | Year: 2014

As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants can also disrupt the prooxidant/antioxidant relationship and contribute to oxidative stress. Increased oxidative stress during pregnancy may be involved in several complications of pregnancy, such as preterm labor, fetal growth restriction, preeclampsia and miscarriage.The aim of this study was to investigate the influence of maternal smoking habits before pregnancy on the parameters of oxidative stress and the antioxidative defense system, lipid profile parameters and paraoxonase-1 (PON1) activity during the third trimester of uncomplicated pregnancies.Healthy pregnant women (n = 86) were divided into non-smoking and smoking groups, and into groups taking vitamin supplements and not taking them. Oxidative damage was measured through the levels of thiobarbituric acid-reacting substances (TBARS) and plasma antioxidant status was evaluated by measuring total antioxidant capacity (TAC).TBARS concetration was significantly higher (p < 0.05) and PON1 activity was significantly lower (p < 0.05) in the smokers group. No significant differences were found in the investigated parameters in relation to vitamin supplement intake.Habitual smoking before pregnancy is associated with increased oxidative stress. Vitamin supplementation has no effect on the oxidative stress status of healthy pregnant women.


Raznatovic S.J.,Narodni Front Clinic of Gynecology and Obstetrics
Medicinski Glasnik | Year: 2012

This work presents the case of the cornual ectopic pregnancy of a twenty year old patient who came to be examined due to amenorrhea which had lasted for seven weeks. Two-dimensional transvaginal ultrasound uncovered the existence of an intact ectopic pregnancy. Use of three-dimensional transvaginal ultrasound in a coronal section confirmed the diagnosis of cornual ectopic pregnancy, and the patient underwent laparatomy. Given that three-dimensional ultrasound enables excellent anatomical orientation and precise localization of pathological findings, especially in the coronal plane of the uterus, it can be expected that this technological advance can improve accuracy in diagnosis of cornual ectopic pregnancy.

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