NARD Institute Ltd.

Amagasaki, Japan

NARD Institute Ltd.

Amagasaki, Japan

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Patent
Nard Institute Ltd. and Murata Manufacturing Co. | Date: 2013-03-28

An electrode active material is based on an organic compound containing in the structural unit thereof a pyrazine structure bound to cycloalkane. The electrode active material and a secondary battery containing it have large energy density, outputting high power, and having excellent cycle characteristics with little reduction in capacity even after repetition of charging and discharging.


Okamoto H.,Okayama University | Yamaji M.,Gunma University | Gohda S.,NARD Institute Ltd. | Kubozono Y.,Okayama University | And 4 more authors.
Organic Letters | Year: 2011

A facile formation of picene was achieved by photosensitization of 1,2-di(1-naphthyl)ethane using 9-fluorenone as a sensitizer. This sensitized photoreaction is the first photochemical cyclization of ethylene-bridged naphthalene moieties to afford the picene skeleton. 5,8-Dibromopicene, prepared by this procedure using 1,2-di[1-(4-bromonaphthyl)]ethane as the substrate, was readily converted to novel functionalized picenes by conventional substitution and cross-coupling reactions. © 2011 American Chemical Society.


Maeda T.,Osaka Prefecture University | Nakao H.,Nard Institute Ltd. | Kito H.,Osaka Prefecture University | Ichinose H.,Osaka Prefecture University | And 2 more authors.
Dyes and Pigments | Year: 2011

Novel squarylium dyes with either terminally placed tetracyanoquinodimethane or tetracyanoanthraquinodimethane moieties as strong electron acceptors were designed and synthesized for use as sensitizers for TiO2-based dye-sensitized solar cells (DSSCs). The photovoltaic performance of DSSCs indicates that two chromophores, strong electron acceptors and squarylium components, make independent contributions to photosensitization of nanocrystalline TiO2. DSSCs fabricated from squarylium-based diads as sensitizers and chenodeoxycholic acid as the coadsorbent exhibited a high open-circuit voltage (up to 0.66 V), suggesting that the electron-accepting components showed some effect on electron injection from the squarylium chromophore to the conduction band of TiO2. Under the coadsorbent-free conditions, the short-circuit photocurrent and overall solar-to-electrical energy conversion efficiency of the photovoltaic cells was improved by the contribution of photosensitizing effect in the wavelength range derived from the electron-acceptor components rather than the squarylium component. This phenomenon implies the possibility that the electron-accepting group acts as an anchoring unit to the TiO2 surface. © 2011 Elsevier Ltd. All rights reserved.


Nakao H.,Nard Institute Ltd. | Nakao H.,Osaka Prefecture University | Maeda T.,Osaka Prefecture University | Nakazumi H.,Osaka Prefecture University
Chemistry Letters | Year: 2013

Novel π-extended squarylium dyes with dicyanovinylene substitution were synthesized through the Stille-type Pdcatalyzed cross-coupling reaction of a precursory iodinated squarylium dye with tributylstannyl squarate. Dye-sensitized solar cells (DSSCs) based on the squarylium dyes displayed remarkable performances in a wide wavelength range from the visible to the near-infrared region around 800 nm. The power conversion efficiencies of the DSSCs based on In-CN-In-S-OH and In-CN-In-S-In-COOH reached 3.5% and 2.1%, respectively. © 2013 The Chemical Society of Japan.


Patent
Osaka University and Nard Institute Ltd. | Date: 2014-02-10

A compound having a structure represented by the general formula (I): (wherein n is 0 or 1; R^(1 )represents a hydrogen atom (only if n=0), a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, an optionally substituted amino group, an optionally substituted phenyl group, a C1-C6 alkylthio group, a C1-C6 alkoxy group, a C1-C6 haloalkoxy group or a C7-C12 aralkyloxy group;R^(2 )represents (CH_(2))_(p)[O(CH_(2))_(q)]_(r)X (wherein X is a halogen atom, p is an integer of 1 to 6, q is an integer of 1 to 4, and r is an integer of 0 to 4);R^(3 )represents a hydrogen atom, a C1-C6 alkyl group, a C7-C16 aralkyl group or a C6-C14 aryl group; andR^(4 )represents a hydrogen atom or a C1-C6 alkyl group), or a pharmaceutically acceptable salt thereof excels FAMT in terms of the tendency to accumulate intensively in cancer, the affinity for LAT1 and the selectivity for cancer, and can be labeled using an automated synthesizer in clinical settings, and therefore is useful as a highly versatile PET imaging agent.


Patent
Nard Institute Ltd. and Osaka University | Date: 2015-11-04

The objective of the present invention is to provide a tyrosine derivative which is useful as a melatonin MT_(1) receptor antagonist, and a method for producing a specific tyrosine derivative with high yield by efficiently introducing an iodine atom at the para position of the phenolic hydroxy group in the benzene ring of tyrosine with good regioselectivity. The tyrosine derivative of the present invention is characterized in being represented by the following formula (I) :^(1) is a protective group of the amino group and the like; R^(2) is a protective group of the carboxy group and the like; R^(3) is a hydrogen atom and the like; R^(4) is a halogen atom and the like; A is -(CH_(2))_(l)-[Z(CH_(2))_(m)]_(n)-; X is a leaving group.


Patent
Osaka University and Nard Institute Ltd. | Date: 2015-12-23

A compound having a structure represented by the general formula (I):R^(1) represents a hydrogen atom (only if n = 0), a halogen atom, a C1-C6 alkyl group, a C1-C6 haloalkyl group, an optionally substituted amino group, an optionally substituted phenyl group, a C1-C6 alkylthio group, a C1-C6 alkoxy group, a C1-C6 haloalkoxy group or a C7-C12 aralkyloxy group;R^(2) represents - (CH_(2))_(p)-[O(CH_(2))_(q)]_(r)-X (wherein X is a halogen atom, p is an integer of 1 to 6, q is an integer of 1 to 4, and r is an integer of 0 to 4);R^(3) represents a hydrogen atom, a C1-C6 alkyl group, a C7-C16 aralkyl group or a C6-C14 aryl group; andR^(4) represents a hydrogen atom or a C1-C6 alkyl group), ora pharmaceutically acceptable salt thereof excels FAMT in terms of the tendency to accumulate intensively in cancer, the affinity for LAT1 and the selectivity for cancer, and can be labeled using an automated synthesizer in clinical settings, and therefore is useful as a highly versatile PET imaging agent.


Eguchi R.,Okayama University | He X.,Okayama University | Hamao S.,Okayama University | Goto H.,Okayama University | And 4 more authors.
Physical Chemistry Chemical Physics | Year: 2013

Field-effect transistors (FETs) based on [6]phenacene thin films were fabricated with SiO2 and parylene gate dielectrics. These FET devices exhibit field-effect mobility in the saturation regime as high as 7.4 cm 2 V-1 s-1, which is one of the highest reported values for organic thin-film FETs. The two- and four-probe mobilities in the linear regime display nearly similar values, suggesting negligible contact resistance at 300 K. FET characteristics were investigated using two-probe and four-probe measurement modes at 50-300 K. The two-probe mobility of the saturation regime can be explained by the multiple shallow trap and release model, while the intrinsic mobility obtained by the four-probe measurement in the linear regime is better explained by the phenomenon of transport with charge carrier scattering at low temperatures. The FET device fabricated with a parylene gate dielectric on polyethylene terephthalate possesses both transparency and flexibility, implying feasibility of practical application of [6]phenacene FETs in flexible/transparent electronics. N-channel FET characteristics were also achieved in the [6]phenacene thin-film FETs using metals that possess a small work function for use as source/drain electrodes. © 2013 the Owner Societies.

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