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Nara, Japan

Nara Institute of Science and Technology , abbreviated as NAIST, is a Japanese national university located in Ikoma, Nara of Kansai Science City. It was founded in 1991 with a focus on research and consists solely of graduate schools in three integrated areas: Biological science, Information science, and Material science. In 2010, NAIST ranked first overall among the 86 Japanese national universities by the Japanese government in its first-ever six-year assessment of national university standards and achievements.The university has a total of about 1,000 Master's and Doctoral students in its three graduate schools , among which 10% are international students . There are about 200 faculty members and 170 staff . Wikipedia.

Morita M.T.,Nara Institute of Science and Technology
Annual Review of Plant Biology | Year: 2010

Plants can reorient their growth direction by sensing organ tilt relative to the direction of gravity. With respect to gravity sensing in gravitropism, the classic starch statolith hypothesis, i.e., that starch-accumulating amyloplast movement along the gravity vector within gravity-sensing cells (statocytes) is the probable trigger of subsequent intracellular signaling, is widely accepted. Several lines of experimental evidence have demonstrated that starch is important but not essential for gravity sensing and have suggested that it is reasonable to regard plastids (containers of starch) as statoliths. Although the word statolith means sedimented stone, actual amyloplasts are not static but instead possess dynamic movement. Recent studies combining genetic and cell biological approaches, using Arabidopsis thaliana, have demonstrated that amyloplast movement is an intricate process involving vacuolar membrane structures and the actin cytoskeleton. This review covers current knowledge regarding gravity sensing, particularly gravity susception, and the factors modulating the function of amyloplasts for sensing the directional change of gravity. Specific emphasis is made on the remarkable differences in the cytological properties, developmental origins, tissue locations, and response of statocytes between root and shoot systems. Such an approach reveals a common theme in directional gravity-sensing mechanisms in these two disparate organs. Copyright © 2010 by Annual Reviews. All rights reserved. Source

Yoshida A.,Nara Institute of Science and Technology
Blood | Year: 2013

The ubiquitin ligase constitutively photomorphogenic 1 (COP1) is involved in many biological responses in mammalian cells, but its role in tumorigenesis remains unclear. Here we show that COP1 is a ubiquitin ligase for the tumor suppressor CCAAT/enhancer-binding protein (C/EBPα) and promotes its degradation in vivo, thereby blocking myeloid differentiation of hematopoietic cells for tumorigenesis. In this process, mammalian homolog of Tribbles, Trib1, which contains a COP1-binding motif, is essential for down-regulation of C/EBPα expression. Murine bone marrow transplantation experiments showed that coexpression of COP1 accelerates development of acute myeloid leukemia induced by Trib1, which pathologically resembles that of p42C/EBPα-deficient mice. Interestingly, coexpression of ligase activity-deficient COP1 mutant abrogated Trib1-induced leukemogenesis. These results indicate that COP1 and Trib1 act as an oncoprotein complex functioning upstream of C/EBPα, and its ligase activity is crucial for leukemogenesis. Source

Nara Institute of Science and Technology | Date: 2014-01-20

The problem of providing a technology that converts a

Tokyo Ohka Kogyo, Nara Institute of Science and Technology | Date: 2013-03-06

A substrate having rod-like molecules on a surface thereof including: a substrate in which a pattern including a convex portion with a flat upper surface is formed on at least a portion thereof; and a plurality of rod-like molecules, which are formed into rod-like shape, are aligned in line in a direction crossing a molecular length direction of each of the rod-like molecules an the upper surface of the convex portion, and have liquid crystalline states, wherein the molecular length L

Nara Institute of Science and Technology | Date: 2013-02-08

The present invention relates to a method of introducing a florigen into a cell of a shoot apical tissue of a plant using a cell-penetrating peptide. More specifically, the present invention relates to a method of introducing a florigen into a cell of a shoot apical tissue of a plant, the method including the step of bringing a solution for florigen introduction containing a florigen and a cell-penetrating peptide in one solvent into contact with a shoot apical tissue of a plant. The present invention also relates to an agent for introducing a florigen into a cell of a shoot apical tissue of a plant, including a florigen and a cell-penetrating peptide, and to a kit for introducing a florigen into a cell of a shoot apical tissue of a plant.

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